Histologic findings at augmented bone areas supplied with two different bone substitute materials combined with sinus floor lifting

Abstract

This case report is focused on the histologic findings of bone tissue supplied with two different hydroxyapatites (HAs) used for maxillary sinus floor grafting in the same patient after various healing intervals. An insufficient unilateral sinus floor grafting with Bio-Oss biomaterial was followed by an additional grafting procedure with Algipore biomaterial performed 4 years later. Bone samples obtained during second-stage dental implantation contained the interesting combination of Bio-Oss, a bovine anorganic bone substitute, and Algipore, a porous algae-derived HA, in close vicinity, yet after different healing periods. Light microscopy exhibited satisfactory osseointegration of both grafting materials. However, Bio-Oss biomaterial showed no evidence of substantial remodeling after a healing period of 4.5 years. On the other hand, Algipore particles demonstrated signs of remodeling by being locally resorbed and partially replaced with newly formed bone already within 6 months.

Chemistry, ultrastructure and porosity of monophasic and biphasic bone forming materials derived from marine algae

“…From our point of view some authors overvalue the importance of the surface area of bioceramics in regards to the biological behaviours [34]. For example the bovine derived HA ceramics show a very high surface area based on nanopores but in vivo they can be characterized as non resorbable [27,35]. This fact supports our assumption, that nanopores play a minor role for bone resorption and remodelling because nanopores are not accessible for bone cell ingrowth.…”

Particle Size of Hydroxyapatite Granules Calcified from Red Algae Affects the Osteogenic Potential of Human Mesenchymal Stem Cells in vitro

“…In this study, the natural macroporous HA ceramic (C Graft™/ Algipore ® ), calcifi ed from red algae (Corallina offi cinalis), with known mechanical and physicochemical properties was used. This material has been proven to have biocompatible properties as a bone graft substitute in vivo [Ewers and Schumann, 1994;Schopper et al, 2003;Ewers et al, 2004]. In vitro studies showed that this material supports the proliferation and differentiation of human osteoblast-like cells on its surface when grown in monolayer [Turhani et al, 2003[Turhani et al, , 2005a and in cellseeded three-dimensional bone composites [Turhani et al, 2005b, d].…”

Developing macroporous bicontinuous materials as scaffolds for tissue engineering

“…The calcium carbonate-based materials also have strong affinity for bone tissue attachment [12] and furthermore, are conducive for osteoblast proliferation and differentiation [13][14][15][16]. These properties make the coral skeleton a suitable candidate for delivering growth factors or bone marrow cells and have been used in numerous clinical applications for more than a decade [1,9,[17][18][19][20].…”