Histologic Findings in T-cell Lymphoma Infiltration of the Optic Nerve

Kitzmann, Anna S.; Pulido, José S.; Garrity, James A.; Witzig, Thomas E.

doi:10.1016/j.ophtha.2008.01.009

Cited by 23 publications

(20 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although ophthalmoscopy is not the standard method for papillary excavation quantification, in this study, all patients who presented papillary excavation ≥ 0.5 and/or any other suspected alteration of the optic disc observed at ophthalmoscopy, were referred for investigation. Epidemiological studies have reported an association between DM and open-angle glaucoma [44–47]. Although this association is not fully understood, it is believed that DM causes microvascular flow impairment in the anterior portion of the optic nerve [48, 49].…”

Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy among Brazilian Xavante Indians

Lima

Franco

Fabbro

et al. 2018

Diabetol Metab Syndr

View full text Add to dashboard Cite

BackgroundTo describe the frequency of diabetic retinopathy (DR) and its associated variables in Brazilian Xavante Indians.MethodsA population-based survey carried out in two Xavante Reservations between 2008 and 2012, included 948 Indians aged 20 years or more, identified 246 individuals with type 2 diabetes. A non-probabilistic cluster sample of 140 diabetic individuals were submitted to ophthalmologic examination. Due to operational conditions and to optimize the field work, only the larger Xavante villages were included. Ophthalmologic examinations were performed during one trip to each reservation, in their villages and consisted of measurement visual acuity, anterior segment biomicroscopy, applanation tonometry, and direct and indirect ophthalmoscopy.ResultsThe frequency of DR was 19.3%, distributed as follows: mild non-proliferative retinopathy in nine (33.3%) subjects, moderate in nine (33.3%), severe in six (22.3%), very severe in two (7.4%), and high-risk proliferative DR in one (3.7%). The occurrence of DR was higher among those with a longer duration of diabetes, higher levels of glycated hemoglobin (HbA1c) and fasting glucose, papillary excavation ≥ 0.5, and among individuals in older age group. Using the log-binomial regression model, diabetes duration > 24 months and HbA1c ≥ 6.5% were significantly associated with the occurrence of DR.ConclusionsThe presence of DR (19.3%) in Xavante Indians is an alert for health care providers for this population, since diabetes is a new disease among them. Its association with disease duration, high levels of HbA1c and blood glucose calls attention for the necessity of more actions to improve diabetes control in this recently contacted ethnic group that needs particular attention.

show abstract

Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy among Brazilian Xavante Indians

Lima

Franco

Fabbro

et al. 2018

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Cases categorized as optic nerve involvement with CNS disease (Table 2) include those that had previously known CNS disease 21,33,55 , presented with decreased vision with simultaneous CNS symptoms 4,30,37 , or presented with decreased vision and simultaneous CNS findings on neuroimaging. 11,40,45,56 …”

Section: Clinical Categories Of Lymphomatous Optic Nerve Involvementmentioning

confidence: 99%

Optic nerve lymphoma: Report of two cases and review of the literature

Kim

Mendoza

Rashid

et al. 2015

Survey of Ophthalmology

View full text Add to dashboard Cite

Lymphoma may involve the optic nerve as isolated optic nerve lymphoma or in association with CNS or systemic lymphoma. We present two biopsy-proven non-Hodgkin lymphomas of the optic nerve and compare our findings with previously reported cases. We discuss the mechanism of metastasis, classification of optic nerve involvement, clinical features, radiologic findings, optic nerve biopsy indications and techniques, histologic features, and treatments. We propose a classification system of optic nerve lymphoma: isolated optic nerve involvement, optic nerve involvement with CNS disease, optic nerve involvement with systemic disease, and optic nerve involvement with primary intraocular lymphoma. Although it is an uncommon cause of infiltrative optic neuropathy, optic nerve metastasis should be considered in patients with a history of lymphoma. The recommended approach to a patient with presumed optic nerve lymphoma includes neuroimaging, and cerebrospinal fluid evaluation as part of the initial work-up, then judicious use of optic nerve biopsy, depending on the clinical situation.

show abstract

“…[130][131][132] optic nerve infiltration from systemic lymphoma is a rare event and typically occurs in established or recurrent systemic lymphoma. 133,134 optic disc changes can be secondary to direct infil tration of the optic nerve head, or to passive swelling resulting from raised iCP. 130 infiltration by leukemic or lymphomatous cells can be unilateral or bilateral, [130][131][132] and is characterized by profound optic disc swelling, vascular tortuosity, splintershaped or flameshaped hemorrhages (commonly in an annular pattern) and venous engorge ment.…”

Section: Imagingmentioning

confidence: 99%

“…Bilateral infiltration can be diffi cult to differentiate from papilledema, although peri vascular infiltration-a common indicator of optic nerve infiltration but never seen in papilledema-can aid in differentiation. 130,132,134 with treatment, swelling often regresses markedly, and in some cases the optic disc returns to its 'normal' appear ance. notably, however, progression to optic disc pallor and atrophy frequently occurs despite treatment.…”

Section: Imagingmentioning

confidence: 99%

See 1 more Smart Citation

The optic nerve head in acquired optic neuropathies

et al. 2010

View full text Add to dashboard Cite

Acquired optic neuropathies are a common cause of blindness in adults, and are associated with characteristic morphological changes at the optic nerve head. Accurate and prompt clinical diagnosis, supplemented with imaging where appropriate, is essential to optimize management of the optic neuropathy and to counsel the patient appropriately on its natural history. History taking, optic disc findings, visual field assessment and imaging of the nerve head and surrounding retinal nerve fiber layer are all paramount to achieving the correct diagnosis. This Review highlights the optic nerve head features that are common to the acquired optic neuropathies, and describes the features that can be used to differentiate these various conditions.

show abstract

Histologic Findings in T-cell Lymphoma Infiltration of the Optic Nerve

Cited by 23 publications

References 11 publications

Diabetic retinopathy among Brazilian Xavante Indians

Diabetic retinopathy among Brazilian Xavante Indians

Optic nerve lymphoma: Report of two cases and review of the literature

The optic nerve head in acquired optic neuropathies

Contact Info

Product

Resources

About