Histologic Investigation of the Female Vesicourethral Junction and Adjacent Tissues for Nerve-sparing Radical Cystectomy

Hinata, Nobuyuki; Hussein, Ahmed A.; Bando, Yukari; Taguchi, Tomoaki; Murakami, Gen; Yamamoto, Masahito; Abe, Shinichi; Guru, Khurshid A.; Fujisawa, Masato

doi:10.1016/j.urology.2020.12.001

Cited by 4 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nerve sparing in female radical cystectomy is a challenging and poorly understood procedure. Bhatta Dhar et al [ 20 ] and Hinata et al [ 21 ] demonstrated the anatomy and surgical procedure of nerve-sparing dissection in female radical cystectomy. However, reports on the oncologic and functional outcomes of the nerve-sparing technique in female radical cystectomy are lacking.…”

Section: Discussionmentioning

confidence: 99%

Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study

et al. 2022

View full text Add to dashboard Cite

Purpose Robot-assisted radical cystectomy (RARC) optimizes patient recovery and has outcomes comparable with those of open surgery. This study aimed to compare the perioperative and oncologic outcomes of RARC in female and male patients. Materials and Methods A retrospective cohort study of the Korean Robot-Assisted Radical Cystectomy Study Group database from 2007 to 2019 identified 749 patients (111 females and 638 males). Female were matched 1:1 to male by propensity score matching using a logistic regression. We compared perioperative outcomes, oncologic outcomes, and complications between the two groups. Results The female group had comparable perioperative outcomes to the male group in terms of operation time, lymph node yield, positive surgical margin, blood transfusion rate, and hospitalization days. Complication rate and grade were not significantly different between the two groups. The most common complication was infection in female and gastrointestinal complications in male. We compared the 5-year overall, disease-specific, and recurrence-free survival of female and male: 58.2% vs. 68.0% (p=0.495), 75.7% vs. 79.3% (p=0.645), and 40.8% vs. 53.5% (p=0.913), respectively. On multivariable analysis, T stage (>T2), postoperative complications, and positive surgical margin were prognostic factors of poor outcome. Sex was not an independent predictor of the three survivals. Conclusions The current study suggests that RARC in female has comparable perioperative and oncologic outcomes to those in male. The complication rate of RARC in female was comparable to that in male, but the type of complications differed by sex.

show abstract

Section: Discussionmentioning

confidence: 99%

Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…When present, autonomic nerves innervating the cavernous tissue and sphincter muscles coursed between the HSM and the VU junction [29 ▪▪ ]. This anatomic landmark was successfully identified intraoperatively during dissection of the VU junction in three separate surgical patients [29 ▪▪ ].…”

Section: Neurovascular Preservationmentioning

confidence: 93%

“…There is recent interest in better understanding the neurophysiology and anatomy of the female sexual response. Hinata et al [29 ▪▪ ] investigated the histology of the fibromuscular construction and nerve distribution around the vesicourethral (VU) junction in 33 female cadaveric samples. In over half of the samples, a mass of smooth muscle and collagen, termed the hiatal smooth muscle (HSM), was identified between the urethra and inferior edge of the levator muscle [29 ▪▪ ].…”

Section: Neurovascular Preservationmentioning

confidence: 99%

“…Hinata et al [29 ▪▪ ] investigated the histology of the fibromuscular construction and nerve distribution around the vesicourethral (VU) junction in 33 female cadaveric samples. In over half of the samples, a mass of smooth muscle and collagen, termed the hiatal smooth muscle (HSM), was identified between the urethra and inferior edge of the levator muscle [29 ▪▪ ]. When present, autonomic nerves innervating the cavernous tissue and sphincter muscles coursed between the HSM and the VU junction [29 ▪▪ ].…”

Section: Neurovascular Preservationmentioning

confidence: 99%

“…In over half of the samples, a mass of smooth muscle and collagen, termed the hiatal smooth muscle (HSM), was identified between the urethra and inferior edge of the levator muscle [29 ▪▪ ]. When present, autonomic nerves innervating the cavernous tissue and sphincter muscles coursed between the HSM and the VU junction [29 ▪▪ ]. This anatomic landmark was successfully identified intraoperatively during dissection of the VU junction in three separate surgical patients [29 ▪▪ ].…”

Section: Neurovascular Preservationmentioning

confidence: 99%

See 2 more Smart Citations

Radical cystectomy and women's sexual health – can we do better?

Escott

Avulova

Bree

et al. 2022

Current Opinion in Urology

View full text Add to dashboard Cite

Purpose of reviewFemale sexual function after radical cystectomy is a crucial, but historically overlooked component of bladder cancer survivorship. This review focuses on recent studies, which have investigated pelvic health and sexual function after radical cystectomy. We discuss modifiable factors, which may contribute to decreased sexual function after radical cystectomy and techniques, which may lead to improved outcomes.Recent findingsSexual function is important to women and there is a significant desire (and unmet need) for more perioperative counseling and discussion regarding sexual function changes and quality of life impacts. Sexual function may be altered due to a combination of hormonal changes from ovarian removal, anatomic changes from vaginal alteration, and sensation changes due to damage to the neurovascular bundle. Techniques to preserve these structures have been developed.SummarySexual function is an important component of survivorship and increasing attention is being focused on this area. Long term studies with objective measures are needed for to compare various techniques and ensure oncologic safety. Ovarian preservation, anterior vaginal wall preservation, and vaginal estrogen replacement should be carefully considered for most patients.

show abstract

Normal Anatomy and Histology

2024

Bladder Pathology

View full text Add to dashboard Cite

Histologic Investigation of the Female Vesicourethral Junction and Adjacent Tissues for Nerve-sparing Radical Cystectomy

Cited by 4 publications

References 27 publications

Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study

Gender-related outcomes in robot-assisted radical cystectomy: A multi-institutional study

Radical cystectomy and women's sexual health – can we do better?

Normal Anatomy and Histology

Contact Info

Product

Resources

About