Histologic Observation of a Human Immature Permanent Tooth with Irreversible Pulpitis after Revascularization/Regeneration Procedure

Shimizu, Emi; Jong, George; Partridge, Nicola C.; Rosenberg, Paul A.; Lin, Louis M.

doi:10.1016/j.joen.2012.06.017

Cited by 144 publications

(127 citation statements)

References 20 publications

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“…Nonetheless, it has been suggested that the use of NaOCl degrades dentin-derived proteins (e.g., BMP-2), which are essential for the odontoblastic differentiation of dental pulp stem cells (Casagrande et al, 2010). From a histological standpoint, currently, only one case report has demonstrated pulp-like tissue formation after the revascularization procedure (Shimizu et al, 2012). Most studies, including findings from animal studies and case reports, show the invaginated tissue consisting of periapical tissue containing bone-like hard tissue and the thickness of root canal walls promoted by cementum-like tissue (Martin et al, 2013;Becerra et al, 2014).…”

Section: Apexification Vs Regenerative Endodonticsmentioning

confidence: 99%

Tissue-engineering-based Strategies for Regenerative Endodontics

et al. 2014

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Stemming from in vitro and in vivo pre-clinical and human models, tissue-engineering-based strategies continue to demonstrate great potential for the regeneration of the pulp-dentin complex, particularly in necrotic, immature permanent teeth. Nanofibrous scaffolds, which closely resemble the native extracellular matrix, have been successfully synthesized by various techniques, including but not limited to electrospinning. A common goal in scaffold synthesis has been the notion of promoting cell guidance through the careful design and use of a collection of biochemical and physical cues capable of governing and stimulating specific events at the cellular and tissue levels. The latest advances in processing technologies allow for the fabrication of scaffolds where selected bioactive molecules can be delivered locally, thus increasing the possibilities for clinical success. Though electrospun scaffolds have not yet been tested in vivo in either human or animal pulpless models in immature permanent teeth, recent studies have highlighted their regenerative potential both from an in vitro and in vivo ( i.e., subcutaneous model) standpoint. Possible applications for these bioactive scaffolds continue to evolve, with significant prospects related to the regeneration of both dentin and pulp tissue and, more recently, to root canal disinfection. Nonetheless, no single implantable scaffold can consistently guide the coordinated growth and development of the multiple tissue types involved in the functional regeneration of the pulp-dentin complex. The purpose of this review is to provide a comprehensive perspective on the latest discoveries related to the use of scaffolds and/or stem cells in regenerative endodontics. The authors focused this review on bioactive nanofibrous scaffolds, injectable scaffolds and stem cells, and pre-clinical findings using stem-cell-based strategies. These topics are discussed in detail in an attempt to provide future direction and to shed light on their potential translation to clinical settings.

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Section: Apexification Vs Regenerative Endodonticsmentioning

confidence: 99%

Tissue-engineering-based Strategies for Regenerative Endodontics

et al. 2014

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“…On the other hand, one study emphasized that calcium hydroxide could damage the epithelial cell rests of Malassez, supposedly an important structure for cell proliferation 12 . Comparing the abovementioned intracanal medications, Bose et al 55 showed that both calcium hydroxide and triple antibiotic paste were effective in assisting pulp-dentin complex. These results occurred when calcium hydroxide insertion was limited to the cervical third of the root canal.…”

Section: Intracanal Medicationsmentioning

confidence: 99%

“…A period of approximately 6 months is required, after the treatment, to evaluate success and to identify treatment progress [55][56] . The literature reports a follow-up period ranging from months to years with different root development outcomes.…”

Section: Follow-upmentioning

confidence: 99%

Pulp revascularization: an alternative treatment to the apexification of immature teeth

Albuquerque

Nagata

Soares

et al. 2014

RGO, Rev. Gaúch. Odontol.

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RESUMOA revascularização pulpar pode ser considerada atualmente como um tratamento alternativo à apicificação e é indicado para dentes com rizogênese incompleta e necessidade de tratamento endodôntico. A apicificação envolve a realização de trocas periódicas em longo prazo de uma pasta de hidróxido de cálcio com o objetivo de formar uma barreira calcificada. Apesar de ser a terapia mais empregada, a permanência desta medicação por longos períodos e as trocas sucessivas, podem levar à fragilização da raiz devido às propriedades higroscópicas e proteolíticas do hidróxido de cálcio, aumentando o risco de fraturas e contaminação do espaço pulpar. Desta forma, tem-se buscado novas alternativas de tratamento que possibilitem o fechamento do forame apical dos dentes imaturos sem que ocorra a fragilização dos mesmos. A revascularização pulpar tem surgido como uma nova opção de tratamento para estimular o término do desenvolvimento radicular e não apenas o fechamento apical. Há na literatura uma variedade de protocolos utilizando esta técnica, buscando sempre alcançar o sucesso no tratamento. Diante dessa variedade, é de grande importância a realização de uma revisão de literatura sobre revascularização pulpar visando reunir, descrever e discutir os diferentes protocolos, para que possam direcionar novas pesquisas e ser empregada de forma adequada pelo clínico. O objetivo desse trabalho é revisar na literatura os diferentes protocolos de revascularização pulpar.Termos de indexação: Polpa dentária. Endodontia. Regeneração. Pulp revascularization: an alternative treatment to the apexification of immature teethRevascularização pulpar: tratamento alternativo à apicificação de dentes jovens com rizogênese incompleta

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“…There are several reports in the literature on the histologic outcome of pulp regeneration in human teeth (71)(72)(73). In 1 of them (73), vital pulplike connective tissue was found in the root canal of a tooth treated 14 months previously with a regenerative endodontic procedure using platelet-rich plasma.…”

Section: Dentin Regeneration Versus Repair With Other Types Of Mineramentioning

confidence: 99%