Histologic Profiles of Breast Reduction Specimens

Ayhan, Sühan; Basterzï, Yavuz; Yavuzer, Reha; Latıfoǧlu, Osman; Çenetoğlu, Seyhan; Atabay, Kenan; Celebi, M.

doi:10.1007/s00266-002-1486-z

Cited by 22 publications

(21 citation statements)

References 2 publications

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“…It is notable that, in a total of 95 patients, normal breast parenchyma was found in only 19 patients, corresponding to 20% of the total. The incidence of atypical and other high risk lesions together in breast reduction specimens is reported to be between 0.68-6.2% (Ayhan et al [12] [14], 6.2%). Differently, the incidence of atypical lesions was found to be 8.4% in this presented study.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic findings in breast reduction specimens

Keçeci¹,

Taşlı²,

Yağcı³

et al. 2013

Journal of Plastic Surgery and Hand Surgery

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Reduction mammaplasty is a commonly performed operation for treatment of breast hypertrophy. It allows examination of specimens from a seemingly healthy population. Although there are many publications reporting the incidence of occult breast carcinomas, only a few studies have specifically examined the incidence of other breast lesions in reduction mammaplasty specimens. The authors conducted a single-centre retrospective chart review examining the incidence of benign and precancerous lesions in breast reduction specimens. Both age and the number of tissue sections were evaluated for the association with important pathologic findings. Of the 95 patients who underwent reduction mammaplasty, eight patients (8.4%) had atypical lesions. Fourteen patients (15%) had proliferative and 54 patients (57%) had non-proliferative breast lesions. No occult invasive breast cancer was identified in the breast reduction specimens. The existence of significant pathologic findings was not associated with age (p = 0.231, student t-test). On the other hand, it was found to be associated with the number of tissue sections (p = 0.046, Mann-Whitney U-test). This study reveals that breast reduction specimens should be analyzed histologically since a considerable amount of patients have breast lesions with increased cancer risk. Therefore, this analysis would guide the management of these patients in the follow-up period.

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Section: Discussionmentioning

confidence: 99%

Histopathologic findings in breast reduction specimens

Keçeci¹,

Taşlı²,

Yağcı³

et al. 2013

Journal of Plastic Surgery and Hand Surgery

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“…Seguindo outra linha de análise, de acordo com a literatura, cerca de 60% das pacientes sem alterações pré-operatórias apresentam alterações benignas nas peças cirúrgicas de mamoplastias 5 . Tafuri e Gobi 3 , em um estudo realizado no Brasil, revisaram 867 peças originadas de mamoplastia redutora bilateral, em pacientes assintomáticas, e verificaram que 50,9% apresentavam alterações fibrocísticas e 10,1%, hiperplasias epiteliais, lesões proliferativas pré-malignas da mama que requerem seguimento mais amiúde.…”

Section: Discussionunclassified

“…Por outro lado, cerca de 60% das pacientes sem alterações nos exames pré-operatórios apresentam alterações benignas nas peças cirúrgicas de mamoplastias. A análise dos tecidos ressecados poderia diagnosticar lesões proliferativas pré-malignas e possibilitar o seguimento adequado dessas pacientes 5 . Assim, estudos regionais devem ser realizados para traçar o perfil de incidência das principais alterações encontradas na população e determinar a real importância da análise das peças ressecadas em termos de saúde pública.…”

Section: Introductionunclassified

Achados histopatológicos de produtos de ressecção em mamaplastias redutoras

Matos¹,

Cavalcante²,

Andrade³

et al. 2011

Rev. Bras. Cir. Plást. (Impr.)

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70Matos JRF et al. Achados histopatológicos de produtos de ressecção em mamaplastias redutorasHistopathological findings in tissue specimens from reduction mammaplasties RESUMO Introdução: A mamoplastia redutora está entre as cinco cirurgias estéticas mais realizadas no Brasil. Não há consenso na literatura sobre a necessidade do exame de rotina dos tecidos ressecados durante o procedimento. Esse trabalho apresenta a estatística dos espécimes obtidos de mamoplastias redutoras e discute a relevância do detalhamento histopatológico dessas peças. Método: Resultados de 96 peças cirúrgicas de reduções mamárias, realizadas durante o período de 2006 a 2010, foram obtidos de uma única instituição e analisados retrospectivamente. Resultados: Alterações histopatológicas foram observadas em 83,3% dos espécimes. As lesões não-proliferativas benignas foram os principais achados, sendo fibrose, adenose e cistos as mais frequentes. Alterações proliferativas foram encontradas em percentual significativo das pacientes (13,54%). Uma paciente (1,16%), com 50 anos de idade, apresentou carcinoma lobular in situ. Pacientes na faixa etária menor que 40 anos não apresentaram lesões malignas ou pré-malignas. Conclusões: A prática rotineira de rastreamento histopatológico de peças de mamoplastias redutoras em pacientes jovens parece discutível, embora tenha sido benéfica em uma paciente com idade superior a 40 anos. Trabalhos adicionais são necessários para definir um grupo em que medidas preventivas teriam melhor relação custo-benefício. Descritores:Mamoplastia. Neoplasias da Mama. Histologia. ABSTRACT Background:Reduction mammaplasty ranks among the top five aesthetic surgical procedures performed in Brazil. No standard pathology assessment for reduction mammaplasty exists. This study presents the reduction mammaplasty specimens findings statistic, and a review about the real relevance of this exam. Methods: Findings of 96 reduction mammaplasty specimens over a 5 years period at a single institution were retrospectively examined. Results: Pathologic findings were present in 83.3%. Non proliferative benign findings are the most frequent lesions, such as fibrosis, adenosis and cists. Proliferative findings are present in 13.54%. A fifth years old patient (1.16%) presented lobular carcinoma in situ. Patients younger than 40 years old did not present maligns and pre-maligns lesions. Conclusions: Routinely practice of histopathological analysis of reduction mammaplasty in young people seems arguable. But this routine was benefit for a patient older than 40 years old. Others studies are need to define a group where preventive measures have a better cost-benefit.

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“…Recently, an increase was reported in the breast cancer incidence of reduction mammoplasty specimens from asymptomatic women. While this rate ranged between 0.006% and 0.6% according to different authors, some authors reported a 2% incidence (1)(2)(3)(4)(5)11,13,(17)(18)(19)(20)(21)(22)(23). For a comparison of histopathological findings on all breast reduction specimens in the literature covering the years 1985-2012, see Table 4.…”

Section: Discussionmentioning

confidence: 99%

Histopathological findings obtained from reduction mammoplasty specimens

Albayrak¹,

Mesci²,

Güler³

2015

Turk J Med Sci

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IntroductionReduction mammoplasty is one of the most commonly performed procedures of plastic surgery. The main physical complaints, secondary to macromastia, include pain in the back, stomach, shoulders, arms, neck, and breasts, and headache, itching, rash, other forms of dermatitis under the breasts, and various paresthesias (1-5). Reduction mammoplasty surgery can also be performed for cosmetic reasons as well as symptomatic causes. In addition to achieving a reduction in the breast volume, breast reduction surgery also enables histopathological investigation of the resected breast tissue, thereby detecting any potential malignant and premalignant lesions, even if the patient does not have any complaints (1,3).Even if only a few specimens are randomly selected and examined among the specimens sent for pathological investigation, a large spectrum of lesions from benign to proliferative lesions, and even malignant ones, can be detected. This trial was designed to retrospectively review the histopathological diagnoses of reduction mammoplasty specimens and to determine the incidence of breast lesions in asymptomatic females. Materials and methodsWe reviewed 106 reduction mammoplasty specimens sent to the Hacettepe University Medical Faculty Pathology Department between 2004 and 2010. We observed that some cases had 2 or more diagnoses. The patients had no symptoms other than macromastia and its associated symptoms. They had applied for cosmetic and reconstructive correction of breast deformities, mostly due to breast hypertrophy.The cases were classified according to age, mean weight of the specimen, number of tissue sections investigated, and pathological findings. The pathological findings were categorized based on the Cancer Committee of the College of American Pathologists consensus established in 1998 (Table 1) (5). The only exception was columnar lesions, which were diagnosed and classified according to Collins and Schnitt (6).Background/aim: Reduction mammoplasty is a common surgical procedure. We report the incidence of nonproliferative and proliferative breast lesions in breast reduction specimens from a single institution over a 6-year period. Materials and methods:The histopathology reports of all patients were analyzed. The clinical and histopathological findings of the patients were recorded.Results: Between 2004 and 2010, 106 patients underwent breast reduction. Fifty-six patients (52.8%) had proliferative breast lesions, 84 patients (79.2%) had nonproliferative lesions, 8 patients (7.5%) had columnar cell lesions without atypia, 61 patients (57.5%) had columnar cell lesions with atypia, 5 patients (4.7%) had atypical ductal hyperplasia, and 6 patients (5.6%) had lobular carcinoma in situ. No invasive breast cancer was identified. Conclusion:In Turkey, there is limited evidence regarding the role of histopathological analysis in reduction mammoplasty. Moreover, none of the previous studies determined columnar cell lesion rates in reduction mammoplasty patients. The detection of significantly elevate...

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Histologic Profiles of Breast Reduction Specimens

Cited by 22 publications

References 2 publications

Histopathologic findings in breast reduction specimens

Histopathologic findings in breast reduction specimens

Achados histopatológicos de produtos de ressecção em mamaplastias redutoras

Histopathological findings obtained from reduction mammoplasty specimens

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