Histologic study of chronic catheter cryoablation of atrioventricular conduction in swine

Fujino, Hidetoshi; Thompson, Robert P.; Germroth, Patricia G.; Harold, Mark E.; Swindle, M. Michael; Gillette, Paul C.

doi:10.1016/0002-8703(93)90752-u

Cited by 32 publications

(19 citation statements)

References 18 publications

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“…The lesion has a mixture of small and large blood vessels and shows minimal Q16 disruption of continuity to the adjacent myocardium. 1,30 The majority of these findings were obtained in animal models, specifically canine and porcine, but were confirmed from human autopsies. 31 …”

Section: Postablation Healingmentioning

confidence: 84%

See 1 more Smart Citation

Cryotherapy of cardiac arrhythmia: From basic science to the bedside

Avitall¹,

Kalinski

2015

Heart Rhythm

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Section: Postablation Healingmentioning

confidence: 84%

“…The lesion site fills with differentiated fibroblasts, creating a moderate degree of fibrosis. 30 . After 12 weeks, the lesion is fibrotic and has no signs of hemorrhage, inflammation, or necrosis ( Figure 3C).…”

Section: Postablation Healingmentioning

confidence: 99%

Cryotherapy of cardiac arrhythmia: From basic science to the bedside

Avitall¹,

Kalinski

2015

Heart Rhythm

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“…Transvenous catheter cryoablation has already been reported, 7,8) however, no electrodes were installed at the tip of the ablation catheter. Previously, hand-held cryoprobe ablation during open heart surgery has been performed, and it was demonstrated that the lesions created by cryoapplication were demarcated and homogeneous.…”

Section: A B C Discussionmentioning

confidence: 99%

Transvenous Catheter Cryoablation of the Atrioventricular Node and Visual Assessment of Freezing of Cardiac Tissue Using Intracardiac Echocardiography

et al. 2004

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SUMMARYWe investigated the use of a catheter-based cryoablation system on atrioventricular (AV) junction ablation in dogs. In five dogs, the cryoablation catheter was introduced to the AV junction area in order to create transient high degree or complete AV block. Cryofreezing energy was applied by lowering the temperature to -75°C for five minutes as a single cycle. This cycle was repeated until significant impairment of the AV conduction appeared. Transient high degree and complete AV block was obtained in all five dogs without any adverse effects. The iceball formation was identified by intracardiac echocardiography. Ablation of the AV junction is effective with several freeze-thaw cycles using a transvenous catheter cryoablation system. (Jpn Heart J 2004; 45: 513-520) Key words: Catheter ablation, Cryofreezing, Catheter ablation, Intracardiac echocardiography CATHETER ablation is a very effective and well-recognized treatment for cardiac arrhythmias.1-3) Radiofrequency (RF) current is the usual source of energy for catheter ablation in clinical practice. The effects of RF application at a specific site cannot be predicted before the actual current delivery. As a result, RE applications frequently create several unsuccessful lesions before a successful site is identified. Prior surgical studies have demonstrated that the sites responsible for arrhythmias can be identified by cryofreezing with a hand-held cryoprobe. 4,5) Cryofreezing can be used to evaluate potential targets before definitive ablation.From the

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“…Using an 11 F catheter with nitrous oxide to take advantage of the Joule-Thompson effect, acute AV block was demonstrated in a closed-chest pig model [24]. Chronic studies performed using an 8F catheter demonstrated persistent AV block in five of eight animals [25]. Cooling of the AV junction resulted in first-degree AV block, which progressed to complete AV block (Fig.…”

Section: Modified Radiofrequency Ablationmentioning

confidence: 99%

“…Percutaneous cryoablation techniques have been examined experimentally and in initial clinical studies [17,18,[24][25][26][27]. Using an 11 F catheter with nitrous oxide to take advantage of the Joule-Thompson effect, acute AV block was demonstrated in a closed-chest pig model [24].…”

Section: Modified Radiofrequency Ablationmentioning

confidence: 99%

Alternate energy sources for catheter ablation

et al. 1999

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Because of the limitations of conventional radiofrequency ablation in creating large or linear lesions, alternative energy sources have been used as possible methods of catheter ablation. Modified radiofrequency energy, cryoablation, and microwave, laser, and ultrasound technologies may be able to create longer, deeper, and more controlled lesions and may be particularly suited for the treatment of ventricular tachycardias and for linear atrial ablation. Future studies will establish the efficacy of these new and promising technologies.

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Histologic study of chronic catheter cryoablation of atrioventricular conduction in swine

Cited by 32 publications

References 18 publications

Cryotherapy of cardiac arrhythmia: From basic science to the bedside

Cryotherapy of cardiac arrhythmia: From basic science to the bedside

Transvenous Catheter Cryoablation of the Atrioventricular Node and Visual Assessment of Freezing of Cardiac Tissue Using Intracardiac Echocardiography

Alternate energy sources for catheter ablation

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