1984
DOI: 10.1007/bf00808259
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Histologic study of ovarian reproductive function in mature mice after antenatal treatment with oxytetracycline

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“…The sensitivity of primary spermatocytes is defined by the stage of the prophase of the first meiotic division. Two stages of preleptotenal transformations of chromosomes were defined in human and mammalian gametogenesis [6,8]; their high sensitivity to damaging factors and manifestations of the damage in the gametes of the progeny have been demonstrated [3,11]. Although spermatids are less sensitive to damaging factors than the preleptotenal stage cells, the synthesis of the components which are necessary for their differentiation into spermatozoa is disrupted [13].…”
Section: Resultsmentioning
confidence: 99%
“…The sensitivity of primary spermatocytes is defined by the stage of the prophase of the first meiotic division. Two stages of preleptotenal transformations of chromosomes were defined in human and mammalian gametogenesis [6,8]; their high sensitivity to damaging factors and manifestations of the damage in the gametes of the progeny have been demonstrated [3,11]. Although spermatids are less sensitive to damaging factors than the preleptotenal stage cells, the synthesis of the components which are necessary for their differentiation into spermatozoa is disrupted [13].…”
Section: Resultsmentioning
confidence: 99%