Histologic transformation of follicular lymphoma: pathologists’                    viewpoint

Maeshima, Akiko Miyagi

doi:10.3960/jslrt.22046

J Clin Exp Hematopathol

2023

DOI: 10.3960/jslrt.22046

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Histologic transformation of follicular lymphoma: pathologists’ viewpoint

Akiko Miyagi Maeshima

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Cited by 3 publications

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New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications

Karube,

Satou,

Kato

2024

Int J Hematol

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New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications

Karube,

Satou,

Kato

2024

Int J Hematol

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Clinicopathological characteristics and genomic profiling in patients with transformed lymphoma: a monocentric retrospective study

Zhao,

Bian,

Hao

et al. 2024

Annals of Medicine

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Background Transformed lymphoma occurs when indolent lymphoma transforms into more aggressive lymphoma usually associated with poor prognosis. Methods In this study, we analysed the immunophenotypes, prognostic factors and outcomes of 35 patients with transformed lymphoma from among 306 marginal zone lymphoma (MZL), 544 follicular lymphoma (FL) and 871 chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) cases. In addition, we performed whole-exome sequencing study of seven transformed MZL (tMZL) cases. Results Our results demonstrate that the median time from indolent lymphoma diagnosis to transformed DLBCL was 35 months (range, 14–53 months). The 5-year overall survival (OS) and progression-free survival (PFS) rates after histological transformation (HT) were 50% and 26%, respectively. Kaplan–Meier survival analysis revealed that asynchronous HT and transformed CLL/SLL (tCLL/SLL) were significant adverse prognostic factors for OS after DLBCL HT. We identified mutations involvement in chromatin remodelling ( CREBBP and EP300 ) and regulators of NF-κB signalling ( TNFAIP3, BCL10, MYD88, CD79B and CARD11 ) were affected in tMZL. Conclusion Whole-exome sequencing and copy-number analysis revealed that tMZL derives from the divergent evolution of an ancestral common progenitor clone (CPC). Collectively, this study provides clinicopathological characteristics of three common types of transformed lymphomas and the genetic profile of tMZL with diagnostic and therapeutic implications.

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Highlights: Follicular lymphoma

Takata

2023

J Clin Exp Hematopathol

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Histologic transformation of follicular lymphoma: pathologists’ viewpoint

Cited by 3 publications

References 45 publications

New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications

New classifications of B-cell neoplasms: a comparison of 5th WHO and International Consensus classifications

Clinicopathological characteristics and genomic profiling in patients with transformed lymphoma: a monocentric retrospective study

Highlights: Follicular lymphoma

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