Histologic transformation to diffuse large B cell lymphoma with profuse signet‐ring cell change in bone marrow and lymph node biopsies in a patient with marginal zone lymphoma. A cytologic‐histologic correlation

Machado, Isidro; Illueca, Carmen; Salazar, Claudia; Mengual, J.; Llombart‐Bosch, Antonio

doi:10.1002/dc.23536

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Among these variants, DLBCL with signet ring cell characteristics is extremely rare. So far, only about seven cases of DLBCL with signet ring cells have been described in the literature; these originated from the lymph nodes, stomach, breast, orbit, and thigh [ 12 – 17 ]. Our case represents the first reported case of systemic DLBCL involving the breast.…”

Section: Discussionmentioning

confidence: 99%

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report

Zhang

Min

et al. 2023

BMC Women's Health

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Background Diffuse large B-cell lymphoma (DLBCL) with signet ring cell components is extremely rare. Here, we present a case of DLBCL with signet ring cell components involving the breast, which can be easily confused with invasive lobular carcinoma of the breast or metastatic signet ring cell carcinoma of gastrointestinal origin. Case presentation A 66-year-old woman presented with a painless mass in her left breast. Enhanced magnetic resonance imaging (MRI) of the breast revealed a 42 × 29 × 28 mm mass in the left breast. Histological examination revealed a diffuse or scattered arrangement of round cells mixed with signet ring-like cells. Immunohistochemically, the neoplastic cells were positive for PAX-5, CD79a, CD20, Bcl-6, and MUM-1 but and negative for cytokeratin, ER, PR, E-cadherin, and P120. The Ki-67 proliferation index was approximately 70%. Fluorescence in situ hybridisation (FISH) demonstrated non-rearrangement of Bcl-2, Bcl-6, and c-MYC genes. Immunohistochemistry and FISH examination confirmed the diagnosis of DLBCL. Subsequently, immunofluorescence showed both IgM and IgG deposits in the signet ring-like lymphocytes. After confirming the diagnosis, the patient received four courses of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemotherapy in a specialist hospital and achieved partial remission; however, she unfortunately died of secondary pneumocystis pneumonia infection 3 months later. Conclusion Malignant lymphoma with signet ring cell morphology is quite uncommon, and this variant can be a diagnostic pitfall. We emphasise that pathologists should consider lymphoma in the differential diagnosis of malignant breast tumours.

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Section: Discussionmentioning

confidence: 99%

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report

Zhang

Min

et al. 2023

BMC Women's Health

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“…Based on the similar heterogeneous feature in gastric and pulmonary MALT lymphoma, one can speculate that both entities share some of the common pathways of progression to a more aggressive form of DLBCL. Studies from gastric MALT lymphoma have suggested that high-grade lymphomas arise through blastic transformation of a low-grade preexisting component, based on the observations that gastric MALT lymphoma is a genetically heterogeneous disease with immunohistochemical evidence of both low- and high-grade clones expressing the same class of immunoglobulin light chains with identical light chain restriction [ 7 – 9 ]. Regression of low-grade gastric MALT lymphoma is very common after eradication of H. pylori , but high-grade components may progress [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Diffuse Large B Cell Non-Hodgkin’s Lymphoma: A Case Report and Literature Review

et al. 2017

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Patient: Female, 48Final Diagnosis: Primary pulmonary DLBCLSymptoms: Cough • weigh lossMedication: R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone)Clinical Procedure: Bone marrow biopsy • CT-guided lung biopsySpecialty: OncologyObjective:Rare diseaseBackground:Primary pulmonary diffuse large B cell lymphoma (DLBCL) is extremely rare neoplasm representing only 0.5–1% of primary pulmonary malignancies. These patients usually have non-specific clinical presentation and radiological findings. Therefore, it is important to increase awareness of this rare disease, as the correct characterization of the tumors will have therapeutic and prognostic implications.Case Report:We present the case of a middle-aged Hispanic woman with chronic cough and an abnormal chest X-ray revealing a lung mass, who was found to have primary pulmonary DLBCL. She underwent 6 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy and attained complete remission.Conclusions:With its non-specific presentation, the diagnosis of primary pulmonary DLBCL is very challenging and often leads to misdiagnosis or delayed diagnosis. The pathogenesis of primary pulmonary DLBCL is still poorly understood. The choice of treatment approach should be based on the biological characteristic of the tumor, stage, and performance status.

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A Rare Case of Signet Ring Cell Lymphoma and Review of the Literature

Işık,

Mert,

Karaçay

et al. 2024

Konuralp Tıp Dergisi

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Signet ring cell lymphoma (SRCL) is a non-Hodgkin's lymphoma with a very rare variant. Although this morphology is frequently seen in follicular lymphoma, it can also be observed in the group of diffuse large B-cell lymphomas. A seventy-six year old woman with known diagnosis of gastric adenocarcinoma, tubular type, moderately differentiate presented with a lymphadenopathy with high FDG uptake (SUVmax: 21.3) in PET/CT during follow-up. A tru-cut biopsy was performed for histopathological diagnosis. Diffuse infiltrative singet ring neoplastic cells showed negativity for PanCK, CK7, CK20, S100, SMA, calretinin and vimentin. The panel was then expanded to include SRCL, a rare variant of lymphoma. Additional immunohistochemical evaluation revealed positivity for CD20, CD19, PAX-5 and Bcl-2. Ki-67 proliferation index was about 80%. CD3, CD30, Myc, Bcl-6, ALK, Cyclin-D1, CD23, CD10, CD21, and MUM-1 were negative. EBER was also negative by chromogen in situ hybridization (CISH). Based on these data, diffuse large B-cell lymphoma (DLBCL) was considered. We herein reported a case of signet ring cell lymphoma discussed its clinical and morphological features with regard to the literature.

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Histologic transformation to diffuse large B cell lymphoma with profuse signet‐ring cell change in bone marrow and lymph node biopsies in a patient with marginal zone lymphoma. A cytologic‐histologic correlation

Cited by 3 publications

References 8 publications

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report

Primary Pulmonary Diffuse Large B Cell Non-Hodgkin’s Lymphoma: A Case Report and Literature Review

A Rare Case of Signet Ring Cell Lymphoma and Review of the Literature

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