Histologic variants of lipid-secreting carcinoma of the breast

Lj, van Bogaert; Maldague, P

doi:10.1007/bf00427064

Cited by 65 publications

(46 citation statements)

References 15 publications

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“…Sebaceous carcinoma is defined as a breast carcinoma with prominent sebaceous differentiation in at least 50% of cells and no evidence of origin from cutaneous adnexal sebaceous glands [12]. To the best of our knowledge, only ten cases of mammary SC are well documented in the English-language literature conforming to the above definition [1,[3][4][5][6][7][8][9]; these cases are summarized in Table IV. One of these cancers occurred in a male patient [3].…”

Section: Discussionmentioning

confidence: 99%

“…At least 90% of tumor [12]. Interestingly, the first three cases of mammary SC were originally described as a variant ("sebaceous-type") of lipid-secreting carcinoma [1]. In contrast to SC, which shows a compact lobulated solid growth pattern and finely vacuolated cells, lipid-rich carcinomas infiltrate like a regular invasive ductal carcinoma and vacuolization is much less conspicuous.…”

Section: Discussionmentioning

confidence: 99%

“…It has been described in 15 cases so far in the English-language literature, either as a minor or predominant component in a classical ductal carcinoma or as a pure line of differentiation [1][2][3][4][5][6][7][8][9][10][11]. According to the current WHO classification, primary sebaceous carcinoma of the breast must show sebaceous differentiation in at least 50% of cells and have no evidence of origin from the cutaneous adnexa [12].…”

Section: Introductionmentioning

confidence: 99%

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Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Švajdler¹,

Baník²,

Poliaková³

et al. 2015

pjp

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Švajdler¹,

Baník²,

Poliaková³

et al. 2015

pjp

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“…Although mammary sebaceous carcinoma was first described as a variant of lipid-secreting carcinoma by van Bogaert and Maldgue in 1977 [15], the recent WHO classification for breast tumors has recognized it as a distinct subtype of invasive breast carcinomas [13]. The number of well-documented cases is still limited [6-8, 12, 16], and we feel that recognition of such a peculiar type of carcinoma is generally poor in this anatomical location.…”

Section: Introductionmentioning

confidence: 92%

Sebaceous carcinoma of the breast: case report and review of the literature

et al. 2006

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Sebaceous differentiation has been described in only limited examples of benign and malignant epithelial lesions of the breast. We report a rare case of mammary sebaceous carcinoma to further delineate its morphologic features. Microscopically, the tumor, arising in the right mammary gland of a 63-year-old woman, was composed of well-defined solid sheets or lobules of atypical epithelial cells including many large pale or clear cells with often scalloped nuclei and coarsely vacuolated cytoplasm, in which abundant lipid droplets were identified with oil-red-O staining. Immunohistochemical expressions of cytokeratin, epithelial membrane antigen, and receptors of estrogen and progesterone were detected, whereas GCDFP-15, S-100 protein, vimentin, alpha-smooth muscle actin, p63, androgen receptor, and the HER2/neu protein were not expressed. Besides, a subset of the tumor cells co-expressed synaptophysin, neurofilament, and PGP9.5, suggesting neuroendocrine differentiation that is a hitherto undescribed phenomenon in the mammary tumors with sebaceous features. This case would expand the morphologic diversity of carcinoma of the breast.

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“…14 Moreover, an intraductal proliferation of sebaceous cells both in human beings 16,19,21 and dogs 14 have been described in literature.…”

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confidence: 99%

Sebaceous metaplasia in a canine mammary gland non-infiltrative carcinoma with myoepithelial component

2011

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Sebaceous metaplasia in canine mammary tumors is a rare condition with only 1 case documented. The current study describes a case of sebaceous metaplasia in a mammary gland carcinoma of an 8-year-old intact, nulliparous female Poodle dog with a subcutaneous tumor located in the left fifth mammary gland. The lesion measured 0.7 cm × 0.5 cm × 0.6 cm in diameter, was firm, circumscribed, painless, non-haired, and non-ulcerated, and did not adhere to deep tissues. The cut surface was non-lobulated, non-encapsulated, whitish to gray, and opaque. Histological evaluation revealed 3 different populations of cells: the first was composed of columnar to cuboidal malignant epithelial cells arranged in intraductal papillary projections, the second of myoepithelial cells associated with a myxoid stroma, and the third presenting sebaceous metaplasia similar to those previously described in both human and veterinary medicine.

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Histologic variants of lipid-secreting carcinoma of the breast

Cited by 65 publications

References 15 publications

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Sebaceous carcinoma of the breast: case report and review of the literature

Sebaceous metaplasia in a canine mammary gland non-infiltrative carcinoma with myoepithelial component

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