Histological Analysis of Microbleed After Surgical Resection in a Patient With Moyamoya Disease  -Case Report-

Kikuta, Ken-ichiro; Takagi, Yasushi; Nozaki, Kazuhiko; Okada, Tsutomu; Hashimoto, Nobuo

doi:10.2176/nmc.47.564

Cited by 35 publications

(21 citation statements)

References 16 publications

(18 reference statements)

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“…30 MBs were detected in 18.8% (3 in hemorrhage groups and 3 in TIA groups) in our series. The incidence of MBs is reported as 14.8%-42%, depending on MR imaging quality such as 1.5T versus 3T or T2* versus SWI technique.…”

Section: Patient Characteristics In Each Presentation Of MMDsupporting

confidence: 45%

“Brush Sign” on Susceptibility-Weighted MR Imaging Indicates the Severity of Moyamoya Disease

Horie¹,

Morikawa²,

Nozaki³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: SWI is a high spatial resolution MR imaging technique showing magnetic inhomogeneity that could demonstrate increased oxygen extraction in focal cerebral ischemia. The aim of this study was to investigate the characteristics in the signal intensity of DMVs by using SWI and to determine whether this method could indicate the severity of the hemodynamics in MMD by evaluating the correlation between SWI stage and hemodynamics on SPECT.

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Section: Patient Characteristics In Each Presentation Of MMDsupporting

confidence: 45%

“Brush Sign” on Susceptibility-Weighted MR Imaging Indicates the Severity of Moyamoya Disease

Horie¹,

Morikawa²,

Nozaki³

et al. 2011

AJNR Am J Neuroradiol

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“…In this study, the majority of CMBs were found in cortical-subcortical locations, and the adjacent arterioles were affected by advanced CAA (vessel wall thickening with amyloid-b (Ab) deposition and lacking a muscularis layer) [42]. Taken together, the findings of neuroimaging-pathological correlation studies, as well as other histopathological analyses of CMBs [38,[44][45][46][47], show that CMBs are commonly associated with two different small-vessel pathologies: hypertensive vasculopathy and CAA. Moreover, these two microangiopathic disorders seem to influence CMB topography.…”

Section: Histopathological Correlates Of Cmbssupporting

confidence: 55%

Cerebral Microbleeds: Detection, Mechanisms and Clinical Challenges

Charidimou

Werring²

2011

Future Neurol.

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In the last decade or so, cerebral microbleeds (CMBs) – tiny perivascular hemorrhages seen as small, well-demarcated, hypointense, rounded lesions on MRI sequences that are sensitive to magnetic susceptibility – have generated increasing interest among neurologists and clinical stroke researchers. As MRI techniques become more sophisticated, CMBs are increasingly detected in various patient populations (including all types of stroke, Alzheimer’s disease and vascular cognitive impairment) and healthy community-dwelling older people. Their presence raises many clinical dilemmas and intriguing pathophysiological questions. CMBs are emerging as an important new manifestation and diagnostic marker of cerebral small-vessel disease. They are a potential predictor of future intracerebral hemorrhage risk, a possible contributor to cognitive impairment and dementia and a potential key link between vascular and degenerative pathologies. In this article, we discuss the available pathological, neuroimaging and clinical studies in the field, and we provide a modern overview of the clinical and pathophysiological implications of CMBs in different disease settings.

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“…2,5 Recent studies demonstrated that the incidence of cerebral microbleeds (cMBs) is higher in Asian patients with MMD in comparison to healthy controls. [7][8][9][10][11] Furthermore, cMBs are a predictor of future intracerebral hemorrhage. 10,12,13 Although there are several studies, which analyzed the frequency, localization, and association of cMBs with intracerebral hemorrhage in Asian patients with moyamoya, there are no equivalent studies of patients outside of Asia.…”

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confidence: 99%

“…10,12,13 Although there are several studies, which analyzed the frequency, localization, and association of cMBs with intracerebral hemorrhage in Asian patients with moyamoya, there are no equivalent studies of patients outside of Asia. [7][8][9][10][11][12][13] The present study attempts to provide additional information about the incidence, distribution pattern, and longitudinal course of cMBs in a German cohort based on a retrospective analysis of magnetic resonance imaging (MRI) studies.…”

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confidence: 99%

Incidence, Locations, and Longitudinal Course of Cerebral Microbleeds in European Moyamoya

Wenz

Maros

et al. 2017

Stroke

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Background and Purpose-Cerebral microbleeds (cMBs) have previously been linked with especially high incidence in Asian patients with moyamoya together with high tendency to bleed. This, presumably, is characteristic of patients with moyamoya. Herein, we, therefore, investigate retrospectively the frequency, location, and longitudinal course of cMBs in a large German cohort. Methods-We included all patients with moyamoya who underwent standard magnetic resonance imaging, including T2*-weighted images, in our department between 1998 and 2015. Two independent readers evaluated magnetic resonance imaging scans to determine the occurrence of cMBs according to the Brain Observer Microbleed Scale. Demographics, initial symptoms leading to hospitalization, and associated diseases were obtained by chart review. Results-Overall, there was a total of 242 T2* studies of 101 included moyamoya patients available with a strong female predominance (69.3%). Eight patients (7.9%) were ≤18 years of age. We detected 25 cMBs within 13 patients (12.9%).One patient <18 of age was presented with a cMB; 2 of 3 patients with an intracranial hemorrhage as initial event demonstrated cMB(s). In 72 of 101 cases, there were 1719 person months of follow-up, with 3 adult patients showing 3 de novo cMBs in the course. The majority of cMBs (64.0%) were located at the cortex/gray-white junction. Conclusions-Although the frequency of cMBs herein is much higher than the expected age-specific incidence, it is still much lower compared with previous reports on cMBs in moyamoya patients of Asian descent. These results might reflect another ethnic-specific difference in patients diagnosed with moyamoya.

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Histological Analysis of Microbleed After Surgical Resection in a Patient With Moyamoya Disease -Case Report-

Cited by 35 publications

References 16 publications

“Brush Sign” on Susceptibility-Weighted MR Imaging Indicates the Severity of Moyamoya Disease

“Brush Sign” on Susceptibility-Weighted MR Imaging Indicates the Severity of Moyamoya Disease

Cerebral Microbleeds: Detection, Mechanisms and Clinical Challenges

Incidence, Locations, and Longitudinal Course of Cerebral Microbleeds in European Moyamoya

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