Histological and Chemical Studies in Man on Effects of Fluoride

Call, R. A.; Greenwood, D. A.; Lecheminant, W. H.; Shupe, J. L.; Nielsen, Henrik Skov; Olson, L. E.; Lamborn, R. E.; Mangelson, Farrin L.; Davis, RB

doi:10.2307/4592465

Cited by 33 publications

(10 citation statements)

References 4 publications

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“…This finding corroborates the re ports of Call et al [1965] and Johnson et al [1979] who observed several subjects with marked chronic bilateral pyelonephritis, whose fluoride concentrations were signifi cantly different from those of comparable subjects.…”

Section: Discussionsupporting

confidence: 81%

Bone Fluoride Concentrations after 16 Years of Drinking Water Fluoridation

Hefti¹,

Marthaler²

1981

Caries Res

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Section: Discussionsupporting

confidence: 81%

Bone Fluoride Concentrations after 16 Years of Drinking Water Fluoridation

Hefti¹,

Marthaler²

1981

Caries Res

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“…The increased fluoride content is confirmatory of the studies carried out previously that uremics will accumulate skeletal fluoride when renal fluoride excretion is reduced (13). Although fluorapatite is less soluble than hydroxylapatite, there was no relation between the fluoride content and the solubility characteristics in the system under study.…”

Section: Synthetic Apatitessupporting

confidence: 71%

A study of vertebral bone powder from patients with chronic renal failure

Kaye¹,

Frueh²,

Silverman³

1970

J. Clin. Invest.

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A B S T R A C T Bone powder from patients dying with chronic renal failure of more than 1 yr duration was shown to release less calcium and more phosphate when equilibrated with a buffer solution, pH 7.4 at 4VC. This change persisted after removal of the organic component and was associated with a reduction in the bone carbonate content. Crystal size and surface area showed no consistent changes from the controls and it was concluded that an alteration in the apatite crystal composition had occurred in long-standing urema with carbonate-phosphate interchange. Support for this was provided by synthesis of apatites which were carbonate deficient and behaved in a similar manner to the uremic bones. INTRODUCTIONWith the development of renal excretory failure and the syndrome of uremia, multiple alterations in the chemical composition of the extracellular fluid occur. While these are many and varied in type, an almost uniform finding is the development of metabolic acidosis with a

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“…Despite the 'black box' approach implicit in clearance studies, a critical concept of tubular fluoride transport arose from these studies. Classical clearance techniques in man [3,5,13] and experimental animals [4.6.25] have shown that over wide variations of plasma fluoride levels, the fluoride clear ance is substantially less than the glomerular filtration rate. Thisindicatesthat the predominant renal mechanisms reg ulating fluoride excretion are filtration and net tubular reabsorption.…”

Section: Discussionmentioning

confidence: 99%

“…Renal failure impairs the ability of the kidney to excrete fluoride [16,19.22], and as a consequence, fluoride concentrations in the circulating blood [22], tissues [21] and bone [3] are increased. Storage of fluoride in the skeleton has been the subject of discussion as an etiologic factor in the development of renal osteodystrophy [20], The lack of adjustment in intestinal fluoride absorption in humans with kidney disease leads to a positive fluoride balance [19].…”

Section: Introductionmentioning

confidence: 99%

Renal Fluoride Excretion: Experimental Evaluation of the Role of Extracellular Volume Status during Intact and Impaired Kidney Function

Schiffl¹,

Hofmann²,

Huggler³

et al. 1981

Nephron

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The renal clearance of inorganic fluoride was studied in 5/6-nephrectomized and kidney-intact rats in order to evaluate the influence of the extracellular fluid volume status on net tubular fluoride reabsorption. Loss of renal functional mass impaired the ability of the hydropenic uremic rat to excrete fluoride, although tubular reabsorption of fluoride was depressed. Fractional fluoride excretion was closely correlated to urinary flow rate in hydropenic rats; no influence of urinary pH from 5.80 to 6.18 could be demonstrated. Acute, moderate expansion of the extracellular fluid volume by isotonic saline was followed by a significant rise in fractional fluoride excretion in uremic as well as in control rats, indicating that extracellular fluid volume is an important physiological determinant of passive tubular fluoride reabsorption.

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Histological and Chemical Studies in Man on Effects of Fluoride

Cited by 33 publications

References 4 publications

Bone Fluoride Concentrations after 16 Years of Drinking Water Fluoridation

Bone Fluoride Concentrations after 16 Years of Drinking Water Fluoridation

A study of vertebral bone powder from patients with chronic renal failure

Renal Fluoride Excretion: Experimental Evaluation of the Role of Extracellular Volume Status during Intact and Impaired Kidney Function

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