Histological and Cytological Changes Produced by Alpha-Particles in the Skin of Mice

Devik, F

doi:10.3109/00016925109136657

Cited by 21 publications

(2 citation statements)

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“…Lei v K r e y b erg and Fin n D e v i k One of us (DEVIK 1951) has in another publication described changes in the epidermis and adjacent tissues, following external irradiation by a 10 mm X 10 mm nickel plate covered with 10 millicuries polonium. One of the problems raised in those experiments was the relationship between the cell damage and cell reaction caused by the direct action of the alpha particles, and the changes caused via the tissue fluids, blood vessels and by other less known factors.…”

Section: Bymentioning

confidence: 99%

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As a counterpart to those experiments, the following investigation was carried out: The same nickel-polonium plate was introduced through an incision under the whole skin in a series of mice, the plate being held in position for a period varying from 20 seconds to 80 minutes, the polonium-covered side facing the epidermis and in actual contact with the loose connective tissue covering the panniculus carnosus.

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mentioning

confidence: 99%

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Observations on the Skin Reaction to the Subcutaneous Application of Metallic Polonium in Mice

Kreyberg¹,

Devik²

1951

Acta Radiologica

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byLei v K r e y b erg and Fin n D e v i k One of us (DEVIK 1951) has in another publication described changes in the epidermis and adjacent tissues, following external irradiation by a 10 mm X 10 mm nickel plate covered with 10 millicuries polonium. One of the problems raised in those experiments was the relationship between the cell damage and cell reaction caused by the direct action of the alpha particles, and the changes caused via the tissue fluids, blood vessels and by other less known factors.As a counterpart to those experiments, the following investigation was carried out: The same nickel-polonium plate was introduced through an incision under the whole skin in a series of mice, the plate being held in position for a period varying from 20 seconds to 80 minutes, the polonium-covered side facing the epidermis and in actual contact with the loose connective tissue covering the panniculus carnosus. The activity of the polonium preparation was, in this case, about 5 millicuries. The same strain of hairless mice, 23 in all, was used as in the previous experiment. It was soon evident that an appreciable amount of polonium was dissolved in the tissue fluid during the period of exposure. Most of the animals developed marked signs of radiation-sickness: asthenia, anemia and loss of body fluid and weight.Of the 23 animals 5 died on the 6th, 7th, loth, loth, and 40th day respectively after the operation, 13 animals were killed for histological examination after a short period after the operation, and 5 were killed after 12 to 26 days exposure.At autopsy the spleen constantly showed a marked or extreme atrophy (Fig. 7), and the bone marrow was often found to be in a gelatinous con-

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Section: Bymentioning

confidence: 99%

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mentioning

confidence: 99%