Histological and Histochemical Studies on the Rat Pituitary Pars Intermedia

Pars Intermedia and Pars Distalis:Two Sites of ACTH Production in the Rat Hypophysis

“…The light microscopic appearance of the pars inter media of the rat has been described [Kurosumi et al, 1962]. Consistent with our previous findings [Gosbee et al, 1970], there was an increase in mean cell size and a relative increase in the number of 'dark' cells following adrenalectomy and a decrease in mean cell size following cortisol administration.…”

Functional Morphology of the Pars Intermedia of the Rat Hypophysis as Revealed with the Electron Microscope

“…Almost all of the secretory granules in the cytoplasm are uniformly electron lucent except for the Golgi region. BARGMANN et al (1967) KUROSUMI et al (1961KUROSUMI et al ( , 1962. Low frequency of the occurrence of the cysts in electron micrographs makes it difficult at present to draw any conclusion concerning their function.…”

Nerve fibers and terminals in the rat anterior pituitary gland as revealed by electron microscopy.

“…It is well known that the pars intermedia contains nerve fibers of the neurosecretory system as observed by both light and electron microscopy (KUROSUMI et al, 1961(KUROSUMI et al, , 1962ZIEGLER, 1963;BARGMANN et al, 1967). Though no report has yet appeared concerning the invasion of neurosecretory axons into the pars distalis, it is not totally impossibile that neurosecretory nerve fibers might enter the pars distalis across the pars intermedia.…”

“…Some of these invading fibers are neurosecretory in nature, being easily recognized under the light microscope due to their strong stainability by Gomori's method (KUROSUMI et al, 1962;ZIEGLER, 1963). Electron microscopy revealed that some axons found in the adenohypophysis contained elementary granules of neurosecretion (KUROSUMI et al, 1961;ZIEGLER, 1963;UNSICKER, 1971;BARGMANN et al, 1967).…”