Histological and immunohistochemical changes in cerebellum of chick embryos after exposure to neonicotinoid insecticide imidacloprid

Singh, Vishram; Hussein, Muktyaz; Singh, Anshul; Hassan, M.A.; Gupta, Prerna

doi:10.1016/j.jasi.2015.10.014

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…Pesticide-induced neurodegeneration has been previously attributed to apoptosis, pyknosis of the cerebellum, and oxidative stress. Additionally, the brain is highly susceptible to oxidative stress and imidacloprid-induced oxidative stress has been linked to cerebellum neurodegeneration inDrosophila melanogaster, female rats, and chick embryos . Despite not measuring oxidative stress in the present study, we did detect differences in brain dimensions between wetland types.…”

Section: Discussioncontrasting

confidence: 68%

“…Additionally, the brain is highly susceptible to oxidative stress and imidacloprid-induced oxidative stress has been linked to cerebellum neurodegenera-tion inDrosophila melanogaster, 32 female rats, 62 and chick embryos. 63 Despite not measuring oxidative stress in the present study, we did detect differences in brain dimensions between wetland types. Specifically, average cerebellum size in juvenile northern leopard frogs was slightly smaller (∼85% difference) at tile wetlands compared to reference wetlands, suggesting that exposure to higher concentrations of contaminants may alter brain morphology.…”

Section: ■ Discussioncontrasting

confidence: 60%

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Connecting the Pipes: Agricultural Tile Drains and Elevated Imidacloprid Brain Concentrations in Juvenile Northern Leopard Frogs (Rana pipiens)

Campbell

Keller

Golovko

et al. 2023

Environ. Sci. Technol.

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Neonicotinoids are neurotoxic insecticides and are often released into nearby wetlands via subsurface tile drains and can negatively impact nontarget organisms, such as amphibians. Previous studies have indicated that imidacloprid, a commonly used neonicotinoid, can cross the amphibian blood–brain barrier under laboratory conditions; however, little is known about the impact of low concentrations in a field-based setting. Here, we report aqueous pesticide concentrations at wetland production areas that were either connected or not connected to agricultural tile drains, quantified imidacloprid and its break down products in juvenile amphibian brains and livers, and investigated the relationship between imidacloprid brain concentration and brain size. Imidacloprid concentrations in brain and water samples were nearly 2.5 and 5 times higher at tile wetlands (brain = 4.12 ± 1.92 pg/mg protein; water = 0.032 ± 0.045 μg/L) compared to reference wetlands, respectively. Tile wetland amphibians also had shorter cerebellums (0.013 ± 0.001 mm), depicting a negative relationship between imidacloprid brain concentration and cerebellum length. The metabolite, desnitro-imidacloprid, had liver concentrations that were 2 times higher at tile wetlands (2 ± 0.3 μg/g). Our results demonstrate that imidacloprid can cross the amphibian blood–brain barrier under ecological conditions and may alter brain dimensions and provide insight into the metabolism of imidacloprid in amphibians.

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Section: Discussioncontrasting

confidence: 68%

Section: ■ Discussioncontrasting

confidence: 60%

Connecting the Pipes: Agricultural Tile Drains and Elevated Imidacloprid Brain Concentrations in Juvenile Northern Leopard Frogs (Rana pipiens)

Campbell

Keller

Golovko

et al. 2023

Environ. Sci. Technol.

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“…Pyknosis, karyolysis, perineuronal edema, reactive astrocytosis, among other histopathological findings in the white Leghorn hen embryos cerebellum [129]. Neurodegeneration, axonal degeneration with demyelination, congestion, perivascular edema, neuronal vacuolization in the Columba livia domestica pigeon [130].…”

Section: Birdsmentioning

confidence: 99%

“…In one of the most recently published studies, it was reported that in chickens, it can generate neurological signs such as muscle tremors, ataxia and depression (Table 4) [82]; in quail, it can increase monoamine levels in the cerebral cortex [115] and alter the activity of acetylcholinesterase in the muscles and brain of the gray laurel wing bird (Table 5) [116]. At the cellular level, it has been associated with neurodegeneration in chicken embryos' cerebellum [129] and pigeons [130]. In experimentation rodents, it has been associated with hypoactivity, increased grooming behavior, and conduct associated with anxiety and depression [93,94].…”

Section: Imidaclopridmentioning

confidence: 99%

Neurotoxic Effects of Insecticides Chlorpyrifos, Carbaryl, Imidacloprid, in Different Animal Species

Mora-Gutiérrez¹,

Rubio²,

Romero-López³

et al. 2022

Neurotoxicity - New Advances

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Insecticides are pesticides used to control insects in agriculture, ornamental gardens, homes, and veterinary medicine. Although the toxic effects on the environment and the health of living beings are not fully understood, these pesticides have become the first options for crop protection in agriculture. After herbicides, insecticides are the most extensively used pesticides in agriculture, with large quantities consumed on every continent, primarily in America. Chlorpyrifos, carbaryl, and imidacloprid are among the top ten most used insecticides. Amidst organophosphates, chlorpyrifos has been reported to be used in over fifty food crops. Carbaryl is a carbamate employed as an insecticide, fungicide, herbicide, and nematicide. Similarly, neonicotinoids are the most used insecticide on a global scale. Neonicotinoids include imidacloprid, the second most frequently used pesticide, surpassed only by glyphosate. It is used because it is less toxic to humans. However, insects appear to be less resistant to its compounds. Evidence suggests that these insecticides persist in soils for a long time and have neurotoxic effects in animal species not intended to receive its consequences. Thus, this chapter’s aim is to describe these three pesticides effects and contrast them with the most recent findings regarding their neurotoxic effects in various animal species.

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“…Imidacloprid was also reported to impact bobwhite quail [Colinus virginianus (Linnaeus)] embryonic development and chick survival, but this depended on specific exposure windows (119). Developmental delay was also noted in chick embryos (120, 121) exposed to imidacloprid, as well as histological changes in the chick cerebellum (122).…”

Section: Neonicotinoid Effects On Vertebratesmentioning

confidence: 99%

Non-target toxicity of novel insecticides

Mužinić

Želježić

2018

Archives of Industrial Hygiene and Toxicology

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Humans have used insecticides since ancient times. The spectrum and potency of available insecticidal substances has greatly expanded since the industrial revolution, resulting in widespread use and unforeseen levels of synthetic chemicals in the environment. Concerns about the toxic effects of these new chemicals on non-target species became public soon after their appearance, which eventually led to the restrictions of use. At the same time, new, more environmentally-friendly insecticides have been developed, based on naturally occurring chemicals, such as pyrethroids (derivatives of pyrethrin), neonicotinoids (derivatives of nicotine), and insecticides based on the neem tree vegetable oil (Azadirachta indica), predominantly azadirachtin. Although these new substances are more selective toward pest insects, they can still target other organisms. Neonicotinoids, for example, have been implicated in the decline of the bee population worldwide. This review summarises recent literature published on non-target toxicity of neonicotinoids, pyrethroids, and neem-based insecticidal substances, with a special emphasis on neonicotinoid toxicity in honeybees. We also touch upon the effects of pesticide combinations and documented human exposure to these substances.

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Histological and immunohistochemical changes in cerebellum of chick embryos after exposure to neonicotinoid insecticide imidacloprid

Cited by 5 publications

References 18 publications

Connecting the Pipes: Agricultural Tile Drains and Elevated Imidacloprid Brain Concentrations in Juvenile Northern Leopard Frogs (Rana pipiens)

Connecting the Pipes: Agricultural Tile Drains and Elevated Imidacloprid Brain Concentrations in Juvenile Northern Leopard Frogs (Rana pipiens)

Neurotoxic Effects of Insecticides Chlorpyrifos, Carbaryl, Imidacloprid, in Different Animal Species

Non-target toxicity of novel insecticides

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