Histological and radiological evaluation of subcutaneous implants in mouse of a 3D-printable material (Fulcure 720) and experimental application in mandibular reconstruction

Barrera, Joaquim Megias; Garcı́a-Consuegra, Luis; Novoa, A.; Costilla, Serafín; Junquera, S.; Ascani, Giuliano

doi:10.1016/j.jormas.2017.11.004

Cited by 2 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The motivation to start working with designed structures was a significant progress in applications of 3D printed materials. Many studies present the possibility to print simple 3D porous structure, that can be successfully applied in the living organism [5,6], however, they are far from obtaining a structure similar to natural bone. Researches on bone structure simulation are becoming more common but still they often have many limitations and simplifications [7].…”

Section: Introductionmentioning

confidence: 99%

Simulation and Optimization of Porous Bone-Like Microstructures With Specific Mechanical Properties

Wit

Wronski

Tarasiuk

2019

APP

View full text Add to dashboard Cite

Bone trabecular structure can be characterized as a connected network of mineral bars and plates with unique mechanical properties. Standard methods of producing bone-like structures based on periodic structures or foams have same limitations. The organization of the trabecular bone (meso scale) is adapted to the values of stresses and strains aﬀecting the skeletal system. To simulate bone-like structure, the methodology of generating stochastic structure based on hyperuniform spatial points distribution is proposed. Statistical analysis of generated structure shows the possibility to generate clouds of points in wide range of random close packing density, up to 59.52%. Points connected by Voronoi tessellation produce to unique porous topology with no closed-cells and with wide range of connectivity. Manufacturing of a generated structure is only limited by used technique. The proposed algorithm was developed regardless of the manufacturing technique, however, same examples of the structure were printed using 3D addictive technology. The mechanical properties of developed structure are strongly dependent on the material from which they are made, but the modiﬁcation of the structure allows to change the strength in speciﬁc and controlled way.

show abstract

Section: Introductionmentioning

confidence: 99%

Simulation and Optimization of Porous Bone-Like Microstructures With Specific Mechanical Properties

Wit

Wronski

Tarasiuk

2019

APP

View full text Add to dashboard Cite

show abstract

Clinically relevant preclinical animal models for testing novel cranio‐maxillofacial bone 3D‐printed biomaterials

Hatt

Thompson

Helms

et al. 2022

Clinical & Translational Med

View full text Add to dashboard Cite

Bone tissue engineering is a rapidly developing field with potential for the regeneration of craniomaxillofacial (CMF) bones, with 3D printing being a suitable fabrication tool for patient‐specific implants. The CMF region includes a variety of different bones with distinct functions. The clinical implementation of tissue engineering concepts is currently poor, likely due to multiple reasons including the complexity of the CMF anatomy and biology, and the limited relevance of the currently used preclinical models. The ‘recapitulation of a human disease’ is a core requisite of preclinical animal models, but this aspect is often neglected, with a vast majority of studies failing to identify the specific clinical indication they are targeting and/or the rationale for choosing one animal model over another. Currently, there are no suitable guidelines that propose the most appropriate animal model to address a specific CMF pathology and no standards are established to test the efficacy of biomaterials or tissue engineered constructs in the CMF field. This review reports the current clinical scenario of CMF reconstruction, then discusses the numerous limitations of currently used preclinical animal models employed for validating 3D‐printed tissue engineered constructs and the need to reduce animal work that does not address a specific clinical question. We will highlight critical research aspects to consider, to pave a clinically driven path for the development of new tissue engineered materials for CMF reconstruction.

show abstract

Histological and radiological evaluation of subcutaneous implants in mouse of a 3D-printable material (Fulcure 720) and experimental application in mandibular reconstruction

Cited by 2 publications

References 16 publications

Simulation and Optimization of Porous Bone-Like Microstructures With Specific Mechanical Properties

Simulation and Optimization of Porous Bone-Like Microstructures With Specific Mechanical Properties

Clinically relevant preclinical animal models for testing novel cranio‐maxillofacial bone 3D‐printed biomaterials

Contact Info

Product

Resources

About