Histological appearance of the intra-osseous vessels of the femoral head in aseptic osteonecrosis of the hip, with or without antiphospholipid antibodies

Laroche, Michel; Ludot, I.; Thiéchart, M.; Viguier, G.; Dromer, C; Mazières, B

doi:10.1007/bf02242453

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Their prothrombotic potential suggests that aPL might predispose to AVN by causing microvascular thrombosis. In fact, thrombosis of terminal arteries in subchondral bone was identified in histological findings in non-traumatic AVN in one study27 but not in another 28. Table 4 shows the various authors reporting an association between aPL and the development of AVN 23-26…”

Section: Discussionmentioning

confidence: 96%

Risk factors for avascular necrosis of bone in patients with systemic lupus erythematosus: Is there a role for antiphospholipid antibodies?

Mok

Farewell

Isenberg

2000

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 96%

Risk factors for avascular necrosis of bone in patients with systemic lupus erythematosus: Is there a role for antiphospholipid antibodies?

Mok

Farewell

Isenberg

2000

Annals of the Rheumatic Diseases

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“…The APS is characterized by arterial and/or venous thromboses of small and large vessels associated with the presence of antiphosphilipid antibodies (aPL), namely LA and/or aCL. Although the role of the aPL in the development of AVN is controversial, [12][13][14][15] recent studies indicate that asymptomatic AVN can be detected by MRI in 20% of the patients with APS 16 and that patients with AVN frequently have high serum levels of aCL. 17 The precise pathogenic mechanism related to the development of AVN in these patients is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

Multifocal avascular necrosis after liver transplantation: an unusual presentation of the antiphospholipid syndrome

Mundó

Peris

Monegal

et al. 2006

Lupus

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We describe the case of a 31-year-old man who presented with an antiphospholipid syndrome (APS), which manifested as multifocal avascular necrosis (AVN) one year after orthotopic liver transplantation. The patient developed multiple AVN affecting hips, left knee, humerus and tarsal bones just after withdrawal of corticosteroid therapy. Three years later when lupus anticoagulant was detected, he began anticoagulant treatment and no further AVN episodes were observed. It is important to be aware of this clinical manifestation of APS, especially in these cases where it can be easily overlooked because of corticosteroid therapy.

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“…The link between APS and avascular necrosis is still unknown [8]. Some authors suggest that antiphospholipids antibodies might predispose to AVN by causing microvascular thrombosis [9][10][11][12].…”

Section: Neurological Manifestations Of Apsmentioning

confidence: 99%

A Mono-Articular Septic Arthritis and Multifocal Avascular Necrosis in Absence of Corticosteroid Use: An Unusual Presentation of Primary Antiphospholipid Syndrome

Fayed¹

2019

Rheumatology

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Osteonecrosis (ON) or avascular necrosis results from disruption of blood supply to bone marrow and trabecular bone leading to death of bone. Antiphospholipid Syndrome (APS) may be primary or secondary to other autoimmune disease. The involvement of multiple sites of ON has been documented with APS. Literature suggests that avascular necrosis predispose a septic arthritis in affected joints especially in immunosuppressed patients.A 29-year-old male patient was a heavy smoker with a past medical history of NSAID abuse and antral and duodenal ulcers. He admitted to the hospital with a sudden severe pain on the medial side of right knee associated with erythema and fever. Figure 1: MRI right knee joint showing diffuse altered marrow signal intensity in tibia and patchy areas of altered signal intensity in lower femur suggesting osteomyelitis with bony infarcts. R heuma to lo g y: Curr e n t R e se arch

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Histological appearance of the intra-osseous vessels of the femoral head in aseptic osteonecrosis of the hip, with or without antiphospholipid antibodies

Abstract: Bone vessel lesions were the same in the three groups.

Cited by 10 publications

References 19 publications

Risk factors for avascular necrosis of bone in patients with systemic lupus erythematosus: Is there a role for antiphospholipid antibodies?

Risk factors for avascular necrosis of bone in patients with systemic lupus erythematosus: Is there a role for antiphospholipid antibodies?

Multifocal avascular necrosis after liver transplantation: an unusual presentation of the antiphospholipid syndrome

A Mono-Articular Septic Arthritis and Multifocal Avascular Necrosis in Absence of Corticosteroid Use: An Unusual Presentation of Primary Antiphospholipid Syndrome

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