Histological Assessment of the Effect of Laser Irradiation on Skin Wound Healing in Rats

Gál, Péter; Vidinský, B; Toporcer, Tomáš; Mokrý, Michal; Mózeš, Š; Longauer, F; Sabó, Ján

doi:10.1089/pho.2006.24.480

Cited by 109 publications

(61 citation statements)

References 26 publications

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“…Low-Level Laser Therapy (LLLT) is an approach increasingly used in medicine, which has potential biostimulating effects also if applied to oral tissues by improving wound healing, enhancing epithelization after periodontal surgery, and preventing or healing induced oral mucositis [4][5][6]. Laser biostimulation can obtain different intracellular biological reactions to stimulate regenerative abilities, without undesired adverse effects, reducing also the pharmacological support and its possible invasiveness.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

et al. 2013

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This is an author version of the contribution published on:Questa è la versione dell 'autore dell'opera: Lasers Med Sci. 2014 Jan;29(1):185-90. doi: 10.1007/s10103-013-1313 The definitive version is available at:La versione definitiva è disponibile alla URL: http://link.springer.com/article/10.1007URL: http://link.springer.com/article/10. /s10103-013-1313 Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Eighty-two lesions were treated. We reported significant reduction in clinical scores of the treated lesions and in reported pain. No detailed complications or therapy side effects were observed during the study. AdrianaAs previously reported by our group with a preliminary report, this study suggests that LLLT could be a possible treatment choice for patients with unresponsive symptomatic OLP, also reducing the possible invasiveness correlated with other therapies.

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Section: Introductionmentioning

confidence: 99%

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

et al. 2013

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“…13 Simi larly, in many ot her pub lis hed pa pers this be nefi ci al ef fect was ob ser ved bet we en the 5 th and 10th days. 22,27 Our fin ding is in ag re e ment with Bisht et al and ot hers. In this pe ri od, an gi o ge ne sis was found to be slightly hig her in la ser gro up.…”

Section: Discussionmentioning

confidence: 62%

“…Alt ho ugh it not al ways easy to strictly se pa ra te the se thre e pha ses from each ot her, the inf lam matory pha se mostly ta kes part du ring the first fi ve days, ho we ver it was shown con ti nu e for 15 days. 27,28 The pro li fe ra tory pha se ge ne rally oc curs on 7 th to 15 th days and then the ma tu ra ti on pha se ta kes pla ce. 27,28 Our ex pe ri men tal mo del con sis ted of a cir cu lar wo und inf lic ted bi la te rally on the dorsum of the rats.…”

Section: Discussionmentioning

confidence: 99%

“…27,28 The pro li fe ra tory pha se ge ne rally oc curs on 7 th to 15 th days and then the ma tu ra ti on pha se ta kes pla ce. 27,28 Our ex pe ri men tal mo del con sis ted of a cir cu lar wo und inf lic ted bi la te rally on the dorsum of the rats. When so me o ne ta kes in to con side ra ti on that pres su re ul cers are ge ne rally cir cu lar rat her than li ne ar, it ap pe ars that our ex pe ri men tal mo del is mo re ap prop ri a te to in ves ti ga te and to adapt the ef fects of dif fe rent the ra pe u tic mo da li ties to cli ni cal prac ti ce.…”

Section: Discussionmentioning

confidence: 99%

“…13,14,33 In a re cent study, Gal et al ha ve shown that la ser sti mu la ti on shor te ned the inf lam ma tory pha se and ac ce le ra ted the pro li fe ra ti on and ma tu ra ti on pha ses. 27 The se inves ti ga tors al so ob ser ved that LLLT po si ti vely sti mu la ted the re ge ne ra ti on of in ju red epi der mis and re pa ir ment of in ju red musc le and conc lu ded that LLLT po si ti vely inf lu en ces all pha ses of rat skin hea ling. In the pre sent study, la ser app li ca ti on sig nifi cantly in cre a sed fib rob last and col la gen com posi ti on on the 7 th day.…”

Section: Discussionmentioning

confidence: 99%

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Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study

Tıkız¹,

Angın²,

Demireli³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate and compare the effects of pulse ultrasound (US) and lowlevel laser therapy (LLLT) on wound healing. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Thirty-two rats were included in the study and two full-thickness skin wounds were made on dorsum area of the rats bilaterally, with a 17 mm hole-punch. The animals were divided into two groups. Pulsed US (with a power of 0.1 W/cm 2 , a frequency of 1 MHz, 5 minutes daily) was applied to to the right sided wounds of Group A (n= 16) and Ga-As laser (830 nm wavelength, 0.5 J/ cm 2 dosage of 1 MHz frequency for 1 minute duration) was applied to right sided wounds of Group B (n= 16). Left sided wound were considered as controls and same procedures were applied without any current (sham). Biochemical and histopathological evaluations were performed in each group on 7 th and 15 th days. R Re es su ul lt ts s: : Inflammatory cells tended to decrease in both treatment groups on the 7 th day, however, this finding did not reach a statistical significance (p> 0.05). Fibroblasts and collagen were found to be significantly increased in the laser group when compared to the other group on the 7 th day (p< 0.05). Angiogenesis was found to be significantly increased only in the laser group when compared to the other group on the 15 th day (p< 0.05). There were no significant differences in tissue nitric oxide values between the groups although the values in the laser group tended to be higher on the 15th day (p=0.058) C Co on nc cl lu us si io on n: : In this comparative study, LLLT was found to significantly accelerate mainly proliferative phase while pulse US had no effect on wound healing. Our results support the consideration that LLLT may constitute a beneficial treatment modality for wound healing.K Ke ey y W Wo or rd ds s: : Laser therapy, low-level; ultrasonography; wound healing Ö ÖZ ZE ET T A Am ma aç ç: : Yara iyileşmesinde düşük enerjili lazer tedavisi (DELT) ve kesikli ultrason (US) tedavilerinin etkinliklerini incelemek ve karşılaştırmak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya 32 rat dahil edildi ve deneklerin dorsal bölgesinde bilateral olarak tüm deri tabakalarını kapsayan 17 mm çapında iki yara oluşturuldu. İki gruba ayrılan deneklerin ilk grubunun (Grup A, n= 16) sağ taraftaki yaralarına kesikli US (1 MHz başlık ile 0.1 W/cm 2 şiddetinde, 5 dakika süreyle) uygulanırken ikinci gruba (Grup B, n= 16) DELT (830 nm dalga boyunda 0.5 j/cm 2 dozunda %50 şiddetinde, 1 dakika süreyle) uygulandı. Sol taraftaki yaralar kontrol olarak alındı ve tedaviler aynı şekillerde ancak ışın verilmeksizin uygulandı (sham). Yedinci ve 15. günlerde sakrifiye edilen deneklerde biyokimyasal ve histopatolojik değerlendirmeler yapıldı. B Bu ul lg gu ul la ar r: : Inflamatuvar hücrelerin yedinci günde her iki tedavi grubunda da azalmış olduğu, ancak istatiksel anlamlılığa ulaşmadığı gözlendi (p> 0.05). Bu dönemde yapılan histolojik incelemelerde fibroblast ve kollajen miktarının lazer g...

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Wounds

Bradley

2017

Laser Therapy in Veterinary Medicine

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Histological Assessment of the Effect of Laser Irradiation on Skin Wound Healing in Rats

Abstract: LLLT at 670 nm positively influences all phases of rat skin wound healing.

Cited by 109 publications

References 26 publications

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study

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