Histological Assessment of the Level of Burn Wound Infection: Diagnostic and Therapeutic Strategies

Lonardo, Antonio Di; Ferrante, M; Maggio, Giulio; Bucaria, V.; Zotti, M. Del; Brienza, E.

doi:10.1007/978-94-009-0361-6_49

Cited by 3 publications

(3 citation statements)

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“…This has led us to suggest that smear test can be relied upon to initiate empirical anti-fungal treatment to curtail delay in confi rmation with culture. Di Lonardo et al found fungal infection on histopathological examination in 16 out of 176 biopsy samples from 40 patients [6]. McManus et al while comparing quantitative microbiology and histopathology in divided burn-wound biopsy specimens found agreement of 96.1% between negative cultures and histologic absence of invasive infection.…”

Section: Discussionmentioning

confidence: 99%

Fungal colonisation in burn wounds: An Indian scenerio

2010

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Section: Discussionmentioning

confidence: 99%

Fungal colonisation in burn wounds: An Indian scenerio

2010

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“…It could be symptomatic and/or may be asymptomatic as a result of immune deficiency secondary to thermal injury, malnutrition, anemia (reperfusion impaired), and damage to barriers (immunological) (15, 16). Periodical culturing and surveillance of potential microorganisms and their sensitivity/susceptibility pattern may alert early management and possible decrease in morbidity and mortality of burn patients from septicemia.…”

Section: Introductionmentioning

confidence: 99%

Bacterial Profile and Antimicrobial Susceptibility Pattern of Isolates Among Burn Patients at Yekatit 12 Hospital Burn Center, Addis Ababa, Ethiopia

Sewunet¹,

Y²,

Mihret³

et al. 2013

Ethiop J Health Sci

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BackgroundInfection is a common cause of morbidity and mortality in burn patients. Clinical diagnosis of bacteremia and/or sepsis in burn patients is difficult for a number of reasons. It could be symptomatic and/or asymptomatic as a result of immune deficiency secondary to thermal injury.MethodsA cross sectional study was conducted at Yekatit 12 Hospital Burn Center. Blood specimen and wound swab were collected from burn patients and were cultured by conventional method. Sensitivity/susceptibility pattern of the isolates was determined by disc diffusion method. Some of the risk factors of bacteremia like prior antibiotic use and total body surface area burn were also determined.ResultsFifty patients were enrolled in the study of whom 21(42%) were found bacteremic. Five different bacteria were isolated from blood specimen. Coagulase negative Staphylococci, 9(42.8%), S. aureus, 8(38.2%), Bacillus spps, 2(9.52%), K. pneumoniae, 1(4.8%), and P. aeruginosa, 1(4.8%), were frequent isolates. From wound swab, S. aureus, (34.04%), and P. aeruginosa, (31.8%), were predominant. Antimicrobial resistance was observed for Ampicillin, (77.4%), Doxycycline, (74.0), Nalidixic acid, (70.5%), Penicillin G, (68.2%), and tetracycline, (67.5%). Total body surface area of burn ≥ 15% was found as a risk factor for bacteremia.ConclusionBacteremia was detected at a rate of 42% among burn patients. Frequent isolates were S. aureus, (34.04%), and P. aeruginosa, (31.8%). About 82.16% of the isolates showed multiple resistances. In light of our findings, regular antibiotic resistance test has to be done for each patient in order to select an appropriate antimicrobial agent.

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“…Di Lonardo et al (2019) found that α-tocopherol acetate as vitamin E (an essential micronutrient with strong antioxidant activity) can stimulate granulation tissue, it seems to reduce bacterial growth, modulate angiogenesis, improve epithelialization, and advanced the healing of potential infective burn wounds. This research is in line with the case study conducted by Firdaus and Pramono (2015) regarding diabetic wound healing.…”

Section: Discussionmentioning

confidence: 99%

Potential of Red Fruit Oil as an Ointment for Burns on Rabbits (Oryctolagus cuniculus)

2024

Int J Vet Sci

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Herbal medicine in Indonesia is often used as a healing medium. Red fruit as one of the endemic medicinal plants in Papua has a high content of various active ingredients and antioxidants so it can treat various diseases. The use of topical medicinal preparations in the form of ointments for the treatment of burns is considered the easiest to apply to livestock. The antioxidant content in red fruit accelerates the regeneration of dead skin cells so it is hoped that it can be used as a topical treatment for burns. Antioxidant therapy for burn management has been widely researched. This study aims to determine the quality and effectiveness of red fruit oil herbal from Papua in the ointment preparations for healing burns in rabbits (Oryctolagus cuniculus). This study used a completely randomized design (CRD) which consisted of 4 treatments. The treatment given was P0 = Vaseline without red fruit oil (negative control); P1 = Red fruit oil ointment 15%; P2 = Red fruit oil ointment 30%; P3 = Red fruit oil ointment 45%. Variables to be measured and observed in this study include the stability of the ointment preparation (organoleptic test, homogeneity test, spreadability test, ointment pH test, and freeze-thaw cycle stability test and the effectiveness of red fruit oil ointment against burns in rabbits. The quality of red fruit oil ointment for the treatment of burns in rabbits (Oryctolagus cuniculus) was the best in the P3 formulation (45% red fruit oil) but in the spreadability test, it was still relatively low.

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Histological Assessment of the Level of Burn Wound Infection: Diagnostic and Therapeutic Strategies

Cited by 3 publications

References 5 publications

Fungal colonisation in burn wounds: An Indian scenerio

Fungal colonisation in burn wounds: An Indian scenerio

Bacterial Profile and Antimicrobial Susceptibility Pattern of Isolates Among Burn Patients at Yekatit 12 Hospital Burn Center, Addis Ababa, Ethiopia

Potential of Red Fruit Oil as an Ointment for Burns on Rabbits (Oryctolagus cuniculus)

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