Histological Behavior of Hepatic Steatosis in Morbidly Obese Patients after Weight Loss Induced by Bariatric Surgery

Abstract

Significant improvement in the hepatic histology of steatosis was observed after weight loss induced by bariatric surgery in most patients. There was no patient with a worsening in the histology.

Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Utility of FIBROspect II to Detect Liver Fibrosis in Morbidly Obese Hispano-American Patients Undergoing Gastric Bypass

“…In our Hispanic population, 58% of the patients had some degree of NASH, and about 35% had some degree of fibrosis. The only patient that had cirrhosis was Hispanic [6,[8][9][10]. Adding the patients with steatosis and NASH, approximately 80% of the patients had some degree of fatty liver disease, which is also similar to what the literature describes [6].…”

“…The exact prevalence of NASH with and without liver fibrosis in the different populations like Caucasians, African American, Hispanics, and Asians has been a matter of research and remains to be clearly defined for each of them [6][7][8][9]. It is of great importance for bariatric surgeons to have clear knowledge of the disease prevalence, behavior, and the available diagnostic tests for liver fibrosis and NASH [10].…”

Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review

“…Table 1 summarizes the main studies on the influence of bariatric surgery on NAFLD. In a historical cohort that enrolled 90 individuals who underwent liver biopsies during RYGB and one year afterwards, Mottin et al 135 observed that the prevalence of hepatic steatosis at the In a retrospective analysis on paired needle liver biopsies taken during and following RYGB in 39 patients, Liu et al 117 observed that the initial prevalences of hepatic pathological conditions were: steatosis (89.7%), hepatocellular ballooning (58.9%) and centrilobular/perisinusoidal fibrosis (50%). These improved significantly after RYGB: steatosis (2.9%), ballooning (0%) and centrilobular fibrosis (25%); significant decreases in the lobular inflammation score and stage of fibrosis were also noted.…”

Predictive Factors of Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients Undergoing Bariatric Surgery

“…One of the most effective and permanent methods for weight loss is bariatric surgery. Recent studies revealed some improvements in steatosis, inflammation, and liver fibrosis after bariatric surgery, but its efficiency for fatty liver and metabolic disorders was not proven so far (16)(17)(18)(19)(20)(21)(22)(23)(24). In contrast to several studies in this matter, there is a lack of a serum marker, which could be a decent predictive of NAFLD or the severity of NASH disease.…”