Histological changes in intervertebral discs after smoking cessation: experimental study using a rat passive smoking model

Nemoto, Yasuhiro; Matsuzaki, Hiromi; Tokuhasi, Yasuaki; Okawa, Akihiro; Uematu, Yoshinao; Nishimura, Taichi; Oda, Hirosi

doi:10.1007/s00776-005-0987-4

Cited by 55 publications

(38 citation statements)

References 13 publications

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“…Vascular insufficiency as a result of atheromas should also be considered. [16][17][18][19][20] Analogous with our results, these presumptions may account for smoking as a cause of rLDH. In contrast with these findings, however, some studies found no relationship between smoking and rLDH.…”

Section: Discussionsupporting

confidence: 89%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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Section: Discussionsupporting

confidence: 89%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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“…Interestingly, after cessation of smoking the fibrous matrix begins to fill cracks and tears in the annulus fibrosus. However, since misalignment is not repaired, it has been noted that structural damage to the annulus fibrosus caused by smoking is irreversible [19]. In our evaluation the patients' smoking habits showed no correlation with AKT gene transcript levels.…”

Section: Smokingcontrasting

confidence: 56%

Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings

et al. 2011

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Intervertebral disc (IVD) degeneration suggests a complex process influenced by genetics, lifestyle and biomechanics, which accounts for the development of low back pain (LBP) and lumbar radiculopathy, a major cause of musculoskeletal disability in humans. The family of Akt/ PKB kinases is a principal mediator in the signal transduction pathways, which contribute to transcriptional regulation, cell growth, proliferation, apoptosis, and survival ability. The purpose of this study was to evaluate the transcriptional profile of the AKT family genes in human herniated discs and the involvement of the PI3K-Akt signaling pathway in human IVD degeneration. Real-time PCR analysis was used to assess the mRNA expression pattern of the three Akt/PKB isoforms in 63 herniated and 10 control disc specimens. Our results showed a significant positive correlation between AKT1 and AKT3 mRNA in herniated discs suggesting a synergistic action between these isoforms in disc herniation. Interestingly, AKT2 mRNA was up-regulated in patients with acute pain during the first 12 months, indicating that AKT2 transcriptional activation may be associated with acute rather than chronic inflammation and phagocytosis. Finally, Akt1/PKB transcription presented a stepwise activation as disc herniation deteriorated. Our findings provide evidence on the transcriptional activation of the Akt/PKB pathway indicating that it is involved in lumbar disc degeneration. There is need for further studies to elucidate the exact role and down-stream signaling action of Akt/PKB isoforms in the pathogenesis of lumbar disc herniation.

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“…Exposure to smoke extract also causes a dose-dependent toxicity in AF and NP cells. The disc is shifted to a catabolic profile with decreased expression of aggrecan, collagen, prostaglandin, and anticatabolic factors tissue inhibitor of matrix metalloproteinases and increasing activity of catabolic matrix metalloproteinases (MMPs) and the proinflammatory cytokine IL-1b [63,66,99,102]. Smoking reduces production of aggrecan, a major proteoglycan component of disc matrix, and increases aggrecan cleavage, which diminishes the hydrostatic properties of aggrecan needed to counteract compressive forces [102].…”

Section: Smokingmentioning

confidence: 99%

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Kadow

Sowa

et al. 2015

Clinical Orthopaedics &Amp; Related Research

221

197

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Background Intervertebral disc degeneration is a common condition with few inexpensive and effective modes of treatment, but current investigations seek to clarify the underlying process and offer new treatment options. It will be important for physicians to understand the molecular basis for the pathology and how it translates to developing clinical treatments for disc degeneration. In this review, we sought to summarize for clinicians what is known about the molecular processes that causes disc degeneration.

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Histological changes in intervertebral discs after smoking cessation: experimental study using a rat passive smoking model

Cited by 55 publications

References 13 publications

Factors that influence recurrent lumbar disc herniation

Factors that influence recurrent lumbar disc herniation

Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

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