Histological Changes in Rat Bronchus-Associated Lymphoid Tissue after Administration of Five Different Antigens

Brugge-Gamelkoorn, Gerda J. van der; Plesch, Benita; Sminia, T.; Langevoort, H. L.

doi:10.1159/000194795

Cited by 21 publications

(11 citation statements)

References 9 publications

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“…Hypertrophied and hyperplasia of BALT were pronounced. These findings were consistent with previous reports [31,32]. Furthermore, emphysema due to the presence of mucus in bronchial lumina was detected, similar finding was also reported [33,34].…”

Section: Discussionsupporting

confidence: 93%

Pathological Study on the Role of Thymoquinone in Experimentally Induced Acute Lung Injury in Rats

Al-Gabri

Ali

AL-Attar

et al. 2017

Zagazig Veterinary Journal

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Acute lung injury (ALI) is a major cause of morbidity and mortality in humans and animals. In traditional and modern medicines, Nigella sativa extract, thymoquinone (TQ) has several benefits. Here, we examined the counter effects of TQ in ALI induced by Lipopolysaccharide (LPS). Tissue sections and serum samples were collected from the following groups of rats: i) none treated control, ii) TQ only, iii) intratracheally (I.T) installed with LPS 200 µg/rat once, iv) TQ protected received intraperitoneally (I.P) 1 mg/rat for one week. Samples were subjected to histopathology, immunohistochemistry, ELISA and electron microscopy. TQ-treated rats revealed reduction in peribronchial, perivascular and interstitial inflammatory edema, thickening of interalveolar septa, inflammatory exudates in the lumens of airways and alveoli, hypertrophied smooth muscles of pulmonary blood vessels and airways and hyperplasia of bronchial associated lymphoid tissue (BALT). Electron microscopy revealed highly activated pneumocyte with vacuolated cytoplasm in TQ-treated group. Immunomodulators, IL1ᵦ and TNFα showed lower levels in TQ-treated group. Meanwhile, NF-κB was absent according to immunohistochemistry. It could be concluded that TQ restores lung architecture and reduces inflammatory Immunomodulators in ALI.

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Section: Discussionsupporting

confidence: 93%

Pathological Study on the Role of Thymoquinone in Experimentally Induced Acute Lung Injury in Rats

Al-Gabri

Ali

AL-Attar

et al. 2017

Zagazig Veterinary Journal

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“…Although the lung is not a site in which germinal centers are typically believed to form, there are reports that organized lymphoid tissue and even germinal centers can be found in the lung after immunization (42). Unlike bronchus-associated lymphoid tissue, which is constitutively present in some species, these organized lymphoid areas are not found in naive mice and must be induced by infection or inflammation (43)(44)(45). Once formed, however, they may serve as sites that can initiate primary immune responses (46,47).…”

Section: Formation Of Germinal Centers and Isotype-switched Ab Responmentioning

confidence: 99%

Lymphotoxin-α-Deficient Mice Make Delayed, But Effective, T and B Cell Responses to Influenza

Lund

Partida-Sánchez

Lee

et al. 2002

The Journal of Immunology

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Lymphotoxin-α−/− (LTα−/−) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice. However, despite these defects we found that LTα−/− mice could survive infection with a virulent influenza A virus. LTα−/− mice and normal wild-type mice infected with influenza A generated similar numbers of influenza-specific CD8 T cells that were able to produce IFN-γ and kill target cells presenting influenza peptides. Furthermore influenza-infected LTα−/− mice produced high titers of influenza-specific IgM, IgG, and IgA. However, both CD8 and B cell immune responses were delayed in LTα−/− mice by 2–3 days. The delayed cellular and humoral immune response was sufficient to mediate viral clearance in LTα−/− mice that were infected with relatively low doses of influenza virus. However, when LTα−/− mice were infected with larger doses of influenza, they succumbed to infection before the immune response was initiated. These results demonstrate that neither LTα nor constitutively organized lymphoid tissues, such as lymph nodes and spleen, are absolutely required for the generation of effective immunity against the respiratory virus influenza A. However, the presence of LTα and/or lymph nodes does accelerate the initiation of immune responses, which leads to protection from larger doses of virus.

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“…Intratracheal BCG challenge in BCG‐vaccinated rabbits results in enhanced antigen transport by BALT 78 . Bronchus‐associated lymphoid tissue of rats shows an increase in the area under the epithelium, a general increase in the number of lymphocytes and more lymphocytes migrating into the epithelium following intratracheal administration of BCG 79 . This suggests that mycobacteria can produce an activation of lymphoepithelial tissues without a marked inflammatory component.…”

Section: Mycobacteria and Maltmentioning

confidence: 99%

Mucosa‐associated lymphoid tissues as sites for uptake, carriage and excretion of tubercle bacilli and other pathogenic mycobacteria

Lugton

1999

Immunol Cell Biol

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Summary Pathogenic mycobacteria, including those that cause tuberculosis and paratuberculosis, cross mucosal barriers by endocytosis within mucosal lymphoepithelial sites. These entry sites commonly include oropharyngeal and nasopharyngeal tonsils and Peyer's patches. Bacilli discharged at the basolateral surfaces of engulfing epithelial M cells are taken up by professional antigen-presenting cells associated with T lymphocytes of the parafollicular area. Dendritic cells and macrophages in these sites allow mycobacterial replication, due to the permissive immunological environment in lymphoepithelial tissues. Abrogation of local delayed-type hypersensitivity reactions generally ensures continuing integrity and function of these tissues. Phagocytes containing intracellular mycobacteria disseminate infection to other parts of the body and also probably migrate back onto the mucosal surface to shed bacilli.

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Histological Changes in Rat Bronchus-Associated Lymphoid Tissue after Administration of Five Different Antigens

Cited by 21 publications

References 9 publications

Pathological Study on the Role of Thymoquinone in Experimentally Induced Acute Lung Injury in Rats

Pathological Study on the Role of Thymoquinone in Experimentally Induced Acute Lung Injury in Rats

Lymphotoxin-α-Deficient Mice Make Delayed, But Effective, T and B Cell Responses to Influenza

Mucosa‐associated lymphoid tissues as sites for uptake, carriage and excretion of tubercle bacilli and other pathogenic mycobacteria

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