Histological Characteristics of Metastasizing Thin Melanomas

Guitart, Joan; Lowe, Lori; Piepkorn, Michael; Prieto, Víctor G.; Rabkin, Michael S.; Ronan, Salve G.; Shea, Christopher R.; Tron, Victor A.; White, Wain L.; Barnhill, Raymond L.

doi:10.1001/archderm.138.5.603

Cited by 162 publications

(126 citation statements)

References 46 publications

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“…Regression can be recognized by the presence of fibrosis, vascular proliferation, melanophages and lymphocytic infiltration. Partial regression was associated with poorer prognosis (Guitart et al, 2002), due to dermal component could have metastasized before it regressed. A previous study revealed there were no association between partial regression of the primary melanoma and SLN involvement by the disease (Fontaine et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6%) cases were male, 730 (46.4%) cases were female. One thousand four hundred forty-seven (92%) cases were invasive melanoma and 127 (8%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9%). It was followed by nodular melanoma in 379 (26.2%), acral lentiginous melanoma (ALM) in 191 (13.2%) and lentigo maligna melanoma in 132 (9.1%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), ≥6/mm 2 mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index; most of the melanoma lesions' thickness were greater than 2 mm, corresponding Clark IV. Vascular invasion and tumor thickness are the most important factors for sentinel lymph node involvement.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Gamsızkan¹,

Yılmaz²,

Büyükbabanı³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Alguns estudos mostraram que MCFs com regressão representam um grupo com alto risco de metástases (4,7,13,14,26,28) ,enquanto outros não demonstraram relação entre estes fatores (12,19,20,21,27,32) . Também tem sido sugerido que tal influência negativa seria mais relevante entre os MCFs do que entre os melanomas espessos, sendo a regressão relacionada com alguns casos de metástases em melanomas in situ (MIS) (6,12,14) .…”

Section: Tabelaunclassified

“…• infiltrado de células mononucleares relacionado diretamente com as células tumorais, podendo infiltrar a epiderme (6,13,14,18,25,34) ;…”

Section: Introductionunclassified

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Estudo da espessura da regressão como fator prognóstico nos melanomas cutâneos finos

Pantaleão¹,

Rochael²

2008

J. Bras. Patol. Med. Lab.

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Introdução: O diagnóstico de melanomas cutâneos finos (MCF) é cada vez mais freqüente. Essas lesões, inicialmente associadas a excelente prognóstico, têm apresentado recidiva ou metástases e, às vezes, óbito. Muitas variáveis têm sido estudadas e, embora nenhuma delas tenha esclarecido tal comportamento, a regressão e seu possível impacto negativo têm merecido atenção. A regressão tardia é referida pelos autores como de maior relevância no prognóstico. Objetivo: Correlacionar a espessura máxima da área de regressão dos MCFs com o tempo de sobrevida livre de doença.

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“…A despeito da incerteza quanto ao significado prognóstico, regressão tem sido usada como componente das tabelas prognósticas da AFIP (Armed Forces Institute of Pathology) e proposta como indicador de propensão a metástases em melanomas finos (Guitart et al, 2002;Cook et al, 2002), fato que tem justificado a realização da biópsia do linfonodo sentinela (Kelly et al, 2001;Shaw et al, 1989;Gersenwald et al, 1999).…”

Section: Discussionunclassified

Melanomas extensivo-superficiais regressivos e não-regressivos finos: análise da densidade microvascular utilizando-se os marcadores D2-40 e CD31

Costa¹

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Histological Characteristics of Metastasizing Thin Melanomas

Cited by 162 publications

References 46 publications

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey

Estudo da espessura da regressão como fator prognóstico nos melanomas cutâneos finos

Melanomas extensivo-superficiais regressivos e não-regressivos finos: análise da densidade microvascular utilizando-se os marcadores D2-40 e CD31

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