Histological Characterization of Invasive Cervical Cancer and Precursor Lesions in Malawian Women Presenting at Queen Elizabeth Central Hospital (QECH): A Cross-Sectional Study

Bangara, Fred Fredrick; Marimo, Clemence; Kaile, Trevor; Simak, Marah; Tomoka, Tamiwe; Arabi, Gani; Kanyenda, Limbikani J.; Phiri, Christopher Newton; Mudenda, Steward

doi:10.4172/2324-8955.1000168

Cited by 2 publications

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“…The majority (70.6%) of cases were cancerous cervical lesions, followed by precancerous cervical lesions (16.8%) and noncancerous cervical lesions (12.6%). A study performed in Malawi on 212 cervical lesions showed that 17% had precancerous lesions, 65% were cancerous, and 18% had both precancerous and cervical cancer, making a total of 83% cancerous lesions [ 28 ]. Another study performed in India on 110 cases showed that a diagnosis of intraepithelial neoplasia was made in 32.7% of cases, and invasive carcinoma was found in 67.3% of cases [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Histopathologic patterns and factors associated with cervical lesions at Jimma Medical Center, Jimma, Southwest Ethiopia: A two-year cross-sectional study

Tirkaso,

Bayisa,

Desta

2024

PLoS ONE

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Background The cervix is the lower portion of the uterus, which connects this organ to the vagina through the endocervical canal. Objective This study aimed to determine the histopathologic patterns and factors associated with cervical lesions at Jimma Medical Center from September 12, 2017, to September 12, 2019. Methods A 2-year facility-based cross-sectional study was conducted from May 1 to June 30, 2020. Result In this study, cervical cancer was the most common (71%) cause of cervical lesions. Squamous cell carcinoma was the most frequent cervical cancer diagnosed during the study, accounting for 96.4% of 331 cancerous cases, followed by adenocarcinoma (3.3%). High-grade squamous intraepithelial lesions were the most frequently diagnosed precancerous lesions, accounting for 68.4% of cases. Endocervical polyps were the most commonly diagnosed benign lesions, accounting for 59.3% of cases. Conclusion The maximum age distribution of cervical lesions was in the 41–50-year age range. Squamous cell carcinoma was the most frequent type of cervical cancer. High-grade squamous intraepithelial lesions were the most frequently diagnosed precancerous cervical lesions. The most common benign cervical lesions were endocervical polyps. Recommendation We recommend educating the community to improve health-seeking behavior and on possible preventive strategies for cervical cancer.

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Section: Resultsmentioning

confidence: 99%

Histopathologic patterns and factors associated with cervical lesions at Jimma Medical Center, Jimma, Southwest Ethiopia: A two-year cross-sectional study

Tirkaso,

Bayisa,

Desta

2024

PLoS ONE

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“…For Correspondence: freshsteward@gmail.com Received on: August 2019 Accepted after revision: September 2019 DOI: 10.30876/JOHR.6.3.2019. [13][14][15][16][17][18][19] Introduction: Liver tumours are tumours that arise from within or outside the liver due to uncontrolled rapid cellular proliferation 1 .Studies have shown that there has been an increase in the incidence of primary and secondary hepatic tumours worldwide 2 . This study was carried to investigate the distribution of primary and secondary liver tumours at the University Teaching Hospitals in Lusaka, Zambia.…”

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confidence: 99%

Characterization of Primary and Secondary Liver Tumours Diagnosed at the University Teaching Hospitals in Lusaka, Zambia

Mudenda¹,

Mufwambi²,

Kaile³

et al. 2019

Journal of Harmonized Research in Medical and Health Sciences

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The incidence and prevalence of liver tumours has increased globally over the past decades. This increase in liver tumours has led to an increase in morbidity and mortality. Phenotypic characterisation of liver tumours is important as it helps in planning for targeted management of diagnosed liver tumours. The aim of this study was to investigate the phenotypic distribution of primary and secondary liver tumours diagnosed at the University Teaching Hospitals in Lusaka, Zambia. Materials/Methods: This was a retrospective cross-sectional study that was conducted on 34 formalin-fixed paraffin embeddedliver tissue blocks at the University Teaching Hospitals. These archived liver tissues were isolated from 2012 to 2015. Tissues were cut for histological analysis using a microtome. Haematoxylin and Eosin staining were done on the slides to confirm hepatic tumour status. Data was analysed using Statistical Package Social Sciences version 20.0. Fisher's exact test was used to determine the association between variables. Statistical significance was conducted at 95% confidence interval with a p<0.05that indicate statistical significance. Results:From the examined 34 cases, the patient age distribution of liver tumours was as follows; <10 years (8.8%), 10-20 years (8.8%), 21-30 years (20.6%), 31-40 years (14.7%), 41-50 years (14.7%), 51-60 years (17.6%), 61-70 years (11.8%), and >70 years (2.9%). Liver tumours affect more males 19/34 (55.88%) than females 15/34 (44.12%). The male to female ratio of patients diagnosed with liver tumours was found to be 1.3:1 and p=0.03. The histological phenotypes of liver tumours recorded in this study included 17/34 (50%) hepatocellular carcinomas, 6/34 (17.6%) metastatic adenocarcinomas, 4/34 (11.8%) intrahepatic cholangiocarcinomas, 3/34 (8.8%) hepatoblastomas, 2/34 (5.9%) metastatic small cell carcinomas, and 2/34 (5.9 %) hepatic adenomas. There was a statistical significance between primary and secondary liver tumours as was evidenced by a p=0.04. Conclusion: Liver tumours affect patients mostly in the age group of 21-30 years. The study further reported that liver tumours affect more males than females. Furthermore, hepatocellular carcinoma, a primary liver tumouristhe most common histologically diagnosed liver tumour at the University Teaching Hospitals followed by metastatic adenocarcinomas.

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Histological Characterization of Invasive Cervical Cancer and Precursor Lesions in Malawian Women Presenting at Queen Elizabeth Central Hospital (QECH): A Cross-Sectional Study

Cited by 2 publications

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Histopathologic patterns and factors associated with cervical lesions at Jimma Medical Center, Jimma, Southwest Ethiopia: A two-year cross-sectional study

Histopathologic patterns and factors associated with cervical lesions at Jimma Medical Center, Jimma, Southwest Ethiopia: A two-year cross-sectional study

Characterization of Primary and Secondary Liver Tumours Diagnosed at the University Teaching Hospitals in Lusaka, Zambia

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