Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants

Liu, Po-Chia; Hung, Yi-Li; Shen, Chung-Min; Chen, Pau‐Chung; Hsieh, Wu‐Shiun

doi:10.1016/j.pedneo.2020.11.009

Cited by 17 publications

(14 citation statements)

References 37 publications

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“…16 Also, in a longitudinal observational study that included 2,390 extremely preterm infants (gestational age <27 weeks), Pappas et al Reported that antenatal exposure to chorioamnionitis appears to increase the likelihood of cognitive impairment as well as death/neurodevelopmental disorders. 25 Although the mortality rate was greatly reduced with surfactant use, the proportion of surviving infants with severe sequelae, such as chronic lung disease, cognitive delay, cerebral palsy, and neurosensory defi cits, did not increase signifi cantly. Although there have been reports of improved neurodevelopmental outcomes in a few small studies, these improvements have not been seen on a global scale.…”

Section: Methodsmentioning

confidence: 97%

“…The results of this study were in line with the theory and supported by other studies in which WHO estimates that out of about 130 million babies born worldwide, 4 million die at neonatal age, most (98%) occur in developing countries. 25 There were multiple risk factors for neonatal mortality including low birth weight (LBW). It was not only a direct cause of death but also a major factor that threatens the newborn's chance of survival.…”

Section: Methodsmentioning

confidence: 99%

“…26 WHO also says that 60-80% of the infant mortality rate (IMR) was caused by low birth weight. 25 76 Hasanuddin, Wijaya and Darussalam Indones J The lower the birth weight, the lower the probability of neonatal survival. The probability of survival increases with higher birth weight.…”

Section: Methodsmentioning

confidence: 99%

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The Impact of Premature Rupture of Membranes (PROM) and Low Birth Weight (LBW) Infant Outcomes to the Survival Rate

Hasanuddin¹,

Wijaya

Darusalam

2022

Indones J Obstet Gynecol

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Abstract Objective: To determine the impact of premature rupture of membranes and the outcome of low birth weight on the survival rate one week after birth in RSUDZA Banda Aceh. Method: This study used an observational analytic study with a prospective cohort study design. The research samples were 84 samples that met the inclusion and exclusion criteria. The data source used was primary data obtained by direct examination by weighing the newborn at birth and during visits. Results: There was an impact of premature rupture of membranes and the outcome of low birth weight on the survival rate of infants after one week. The results showed that the p-value <0.000. The lowest neonatal survival rate was in the group weighing less than 1000 grams, namely 0%. Weight group 1000 grams to 1500 grams with a survival rate of 55% and group weight 1500 grams to 2500 grams with a survival rate of 95%. Discussion: There was an impact of premature rupture of membranes and the outcome of low birth weight on the survival rate one week after birth in RSUDZA Banda Aceh. Keywords: low birth weight (LBW), preterm premature rupture of membranes, survival rate. Abstrak Tujuan : Untuk mengetahui dampak ketuban pecah dini dengan luaran berat badan lahir rendah terhadap survival rate satu minggu setelah dilahirkan di RSUDZA Banda Aceh. Metode: Penelitian ini menggunakan studi analitik observasional dengan desain penelitian kohort prospektif. Sampel penelitian sebanyak 84 sampel yang memenuhi kriteria inklusi dan eksklusi. Sumber data yang digunakan adalah data primer yang diperoleh dengan cara pemeriksaan langsung dengan penimbangan bayi saat baru lahir dan ketika kunjungan. Hasil: Ada dampak ketuban pecah dini dengan luaran berat badan lahir rendah terhadap survival rate bayi setelah satu minggu didapatkan hasil bahwa p-value <0,000. Survival rate neonatal terendah pada kelompok berat badan di bawah 1000 gram yakni 0%. Kelompok berat badan 1000 gram sampai di bawah 1.499 gram memiliki survival rate 55% dan kelompok berat badan 1.500 gram sampai 2.499 gram memiliki angka survival rate 95%. Diskusi: Ada dampak ketuban pecah dini dengan luaran berat badan lahir rendah terhadap survival rate satu minggu setelah bayi dilahirkan di RSUDZA Banda Aceh. Kata kunci: berat badan lahir rendah (BBLR), ketuban pecah dini, survival rate.

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Section: Methodsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

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The Impact of Premature Rupture of Membranes (PROM) and Low Birth Weight (LBW) Infant Outcomes to the Survival Rate

Hasanuddin¹,

Wijaya

Darusalam

2022

Indones J Obstet Gynecol

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“…Prematurity itself and the subsequent arrest of lung maturation at the early stages of lung development is the major determinant of the disease. In addition, prenatal events, including placental dysfunction, pre-eclampsia, intrauterine growth restriction, chorioamnionitis, maternal smoking and postnatal iatrogenic insults, such as nutritional deficiencies, direct injury from mechanical ventilation and oxygen toxicity, further worsen the picture, all playing a role in the resulting pulmonary inflammation 2 7. Infants suffering from severe BPD are difficult to wean from respiratory support, they often experience feeding intolerance and intermittent hypoxic episodes,8 requiring a prolonged hospital stay and often needing discharge on home on oxygen 6.…”

Section: Introductionmentioning

confidence: 99%

Steroid use for established bronchopulmonary dysplasia: study protocol for a systematic review and meta-analysis

et al. 2022

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IntroductionPostnatal steroids during the first few weeks of life have been demonstrated to be effective in decreasing the incidence of bronchopulmonary dysplasia (BPD), a serious chronic respiratory condition affecting preterm infants. However, this preventive option is limited by the concern of neurological side effects. Steroids are used to treat established BPD in an attempt to reduce mortality, and length of stay and home oxygen therapy, both of which associated with high levels of parental stress and healthcare costs. Moreover, a late timing for steroid treatment may show a more favourable safety profile in terms of neurodevelopment outcomes, considering the added postnatal brain maturation of these infants. Here, we report a protocol for a systematic review, which aims to determine the efficacy and long-term safety of postnatal steroids for the treatment of established BPD in preterm infants.Methods and analysisMEDLINE, Embase, Cochrane databases and sources of grey literature for conference abstracts and trial registrations will be searched with no time or language restriction. We will include case–control studies, cohort studies and non-randomised or randomised trials that evaluate postnatal steroids for infants diagnosed with moderate or severe established BPD at 36 weeks’ postmenstrual age. We will pool data from studies that are sufficiently similar to make this appropriate. Data extraction forms will be developed a priori. Observational studies and non-randomised and randomised clinical trials will be analysed separately. We will combine OR with 95% CI for dichotomous outcomes and the mean difference (95% CI) for continuous outcomes. We will account for the expected heterogeneity by using a random-effects model. We will perform subgroup analysis based on the a priori determined covariate of interest.Ethics and disseminationSystematic reviews are exempted from approval by an ethics committee. Attempts will be sought to publish all results.PROSPERO registration numberCRD42021218881.

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“…Prematurity itself and the subsequent arrest of lung maturation at the early stages of lung development is the major determinant of the disease. In addition, prenatal events, including placental dysfunction, pre-eclampsia, intrauterine growth restriction (IUGR), chorioamnionitis, maternal smoking, and postnatal iatrogenic insults, such as nutritional de ciencies, direct injury from mechanical ventilation and oxygen toxicity, further worsen the picture, all playing a role in the resulting pulmonary in ammation (2,7). Infants suffering from severe BPD are di cult to wean from respiratory support, they often experience feeding intolerance and intermittent hypoxic episodes (8), requiring prolonged hospital stay and often needing discharge on home on oxygen (6).…”

Section: Introductionmentioning

confidence: 99%

Steroid Use for Established Bronchopulmonary Dysplasia: Study Protocol for a Systematic Review and Meta-analysis.

Strashun¹,

Seliga‐Siwecka²,

Chioma³

et al. 2021

Preprint

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BackgroundBronchopulmonary dysplasia (BPD) is a serious chronic respiratory condition that affects approximately 60% of preterm infants born before 27 weeks’ gestation, and leads to both, short and long-term pulmonary and non-pulmonary complications. Infants suffering from BPD are difficult to wean off of respiratory support, delaying feeding advancement and hospital discharge. Postnatal steroids during the first three weeks of life have been demonstrated to be effective in decreasing the incidence of BPD, however concerns in relation to neurodevelopmental outcomes are reported as well. On the contrary, data regarding the use of late postnatal steroids, once BPD is established are sparse and inconsistent. Here, we report a protocol for a systematic review, which aims to determine the efficacy and long-term safety of post-natal steroids for the treatment of established BPD in preterm infants.MethodsMEDLINE, Embase, Cochrane databases and sources of grey literature will be searched with no time or language restriction for studies that evaluated the use of postnatal steroids for preterm infants with established BPD. Odds ratios and 95% confidence intervals will be determined and pooled using a random effects model. For the studies that cannot be combined in the meta-analysis, a narrative synthesis of the results will be provided. DiscussionThe use of steroids as a therapeutic option for established BPD, after reaching the critical phase of the disease, is limited by the concern of possible neurological side effects that were documented for the preventive use of this medication. However, steroid treatment for established BPD may be administered in an attempt to reduce length of stay and home oxygen therapy, which are both associated with high levels of parental stress and healthcare costs. Moreover, a late timing for steroid treatment may show a more favourable safety profile in terms of neurodevelopment outcomes, considering the added postnatal brain maturation of these infants. As BPD is one of the neonatal complications that lack an effective course-modifying treatment approach to-date, the proposed systematic review offers considerable clinical relevance.Systematic review registration The protocol is registered in the PROSPERO register (registration number CRD42021218881).

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Histological chorioamnionitis and its impact on respiratory outcome in very-low-birth-weight preterm infants

Cited by 17 publications

References 37 publications

The Impact of Premature Rupture of Membranes (PROM) and Low Birth Weight (LBW) Infant Outcomes to the Survival Rate

The Impact of Premature Rupture of Membranes (PROM) and Low Birth Weight (LBW) Infant Outcomes to the Survival Rate

Steroid use for established bronchopulmonary dysplasia: study protocol for a systematic review and meta-analysis

Steroid Use for Established Bronchopulmonary Dysplasia: Study Protocol for a Systematic Review and Meta-analysis.

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