Histological conversion of seminoma of testis to metastatic choriocarcinoma in left cervical lymph node: An unusual phenomenon

Dasgupta, Shirin; Mohapatra, Debahuti

doi:10.4103/jdrntruhs.jdrntruhs_18_21

J NTR Univ Health Sci

2021

DOI: 10.4103/jdrntruhs.jdrntruhs_18_21

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Histological conversion of seminoma of testis to metastatic choriocarcinoma in left cervical lymph node: An unusual phenomenon

Shirin Dasgupta

Debahuti Mohapatra

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2024

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A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Huang,

Zheng,

Bao

et al. 2024

Front. Med.

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BackgroundNon-gestational choriocarcinoma, also known as primary choriocarcinoma, is extremely rare in men, manifesting with specific signs such as breast feminization, testicular atrophy, and loss of libido. The presentation typically includes elevated serum β-hCG levels, widespread metastatic disease, and a rapid progression of the condition.Case reportWe present a rare case of a 41-year-old man diagnosed with choriocarcinoma, exhibiting a unique combination of multiple metastases, including lung, brain, bone, and retroperitoneal lymph node metastases, as confirmed by 18F-FDG PET/CT imaging. The patient was treated with aggressive chemotherapy and pembrolizumab, and the prognosis remained poor. The patient’s overall survival was a mere 5 months following diagnosis.ConclusionNon-gestational choriocarcinoma represents a rare entity in clinical practice and should be considered in young men presenting with gynaecomastia and elevated β-hCG levels alongside normal gonads. Thus, we advocate for a more comprehensive inquiry into medical history and a systematic examination. The 18F-FDG PET/CT examination not only visually delineates the lesion’s location and extent but also serves as a cornerstone for clinical tumor staging, providing valuable support for treatment monitoring and subsequent follow-up.

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A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

Huang,

Zheng,

Bao

et al. 2024

Front. Med.

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show abstract

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Histological conversion of seminoma of testis to metastatic choriocarcinoma in left cervical lymph node: An unusual phenomenon

Cited by 1 publication

References 3 publications

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

A poor prognostic male choriocarcinoma with multiple systemic metastases: a case report and the literature review

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