Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia

Romero-Pimentel, Ana Luisa; Vázquez-Roque, Rubén Antonio; Camacho-Ábrego, Israel; Hoffman, Kurt L.; Linares, P.; Flores, Gonzalo; Manjarrez, Elı́as

doi:10.1016/j.schres.2014.09.009

Cited by 11 publications

(5 citation statements)

References 65 publications

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“…The final hypothesis is consistent with the observation of low spine densities on the basilar dendrites of pyramidal neurons and decreased neuropil in postmortem cortical samples from patients with SZ, especially in cortical layers subserving corticocortical and thalamocortical connectivity [ 53 ]. This hypothesis is also consistent with findings in animal models of SZ (e.g., the NLHV rat model) that have demonstrated reduced numbers of neurons in the auditory cortex [ 41 ].…”

Section: Discussionsupporting

confidence: 91%

N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth

et al. 2016

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Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease's pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. Testing such therapies requires noninvasive methods that can assess engagement of target mechanisms. The auditory N100 is an obligatory cortical response whose amplitude decreases with tone repetition. This adaptation may index the health of plasticity mechanisms required for normal development. We exposed participants aged 5 to 17 years with psychosis (n = 22), at clinical high risk (CHR) for psychosis (n = 29), and healthy controls (n = 17) to an auditory tone repeated 450 times and measured N100 adaptation (mean amplitude during first 150 tones − mean amplitude during last 150 tones). N100 adaptation was reduced in CHR and psychosis, particularly among participants <13 years old. Initial N100 blunting partially accounted for differences. Decreased change in the N100 amplitude with tone repetition may be a useful marker of defects in neuroplastic mechanisms measurable early in life.

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Section: Discussionsupporting

confidence: 91%

N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth

et al. 2016

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“…Before sectioning, brains were placed in a sucrose gradient and then 50-m-thick coronal sections from PFC were obtained using a cryostat (Leica, CM1510-1) and mounted on gelatin-coated microscope slides. For stereological analysis, brain slices were stained with cresyl violet and systematically random sampled with an optical fractionator probe (Vázquez-Roque et al, 2012Romero-Pimentel et al, 2014). Neurons were identified by their size and shape (Chareyron et al, 2012), using a MBF CX9000 color CCD camera (MicroBrightField) coupled to an Olympus BX51WI microscope and sampled at 60ϫ (UPlanSAPO 60ϫ N.A.…”

Section: Neuronal Density Stereological Analysismentioning

confidence: 99%

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

et al. 2019

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Reduction of the dendritic arbor length and the lack of dendritic spines in the pyramidal cells of the prefrontal cortex (PFC) are prevalent pathological features in schizophrenia (SZ). Neonatal ventral hippocampus lesion (NVHL) in male rats reproduces these neuronal characteristics and here we describe how this is a consequence of BDNF/TrkB pathway disruption. Moreover, COX-2 proinflammatory state, as well as Nrf-2 antioxidant impairment, triggers oxidative/nitrosative stress, which also contributes to dendritic spine impairments in the PFC. Interestingly, oxidative/nitrosative stress was also detected in the periphery of NVHL animals. Furthermore, risperidone treatment had a neurotrophic effect on the PFC and antioxidant effects on the brain and periphery of NVHL animals; these cellular effects were related to behavioral improvement. Our data highlight the link between brain development and immune response, as well as several other factors to understand mechanisms related to the pathophysiology of SZ.

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“…The CB1 receptor agonist CP-55940 significantly disrupted auditory gating as well as neuronal theta and gamma network oscillations in the hippocampus and entorhinal cortex in anesthetized and freely moving rats [121,122]. In the neonatal ventral hippocampal lesion model of schizophrenia, sensory gating function is impaired and is associated with a prolonged latency from S1 to N1 and reduced phase-locked theta and gamma oscillations, particularly at S1 [122,123]. Finally, in transgenic mouse models of AD, information processing deficits are associated with an altered excitation-inhibition balance in brain-wide neuronal networks.…”

Section: Pharmaco-event-related Potentialsmentioning

confidence: 99%

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Drinkenburg

Ruigt²,

Ahnaou

2015

Neuropsychobiology

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The contemporary value of animal pharmaco-electroencephalography (p-EEG)-based applications are strongly interlinked with progress in recording and neuroscience analysis methodology. While p-EEG in humans and animals has been shown to be closely related in terms of underlying neuronal substrates, both translational and back-translational approaches are being used to address extrapolation issues and optimize the translational validity of preclinical animal p-EEG paradigms and data. Present applications build further on animal p-EEG and pharmaco-sleep EEG findings, but also on stimulation protocols, more specifically pharmaco-event-related potentials. Pharmaceutical research into novel treatments for neurological and psychiatric diseases has employed an increasing number of pharmacological as well as transgenic models to assess the potential therapeutic involvement of different neurochemical systems and novel drug targets as well as underlying neuronal connectivity and synaptic function. Consequently, p-EEG studies, now also readily applied in modeled animals, continue to have an important role in drug discovery and development, with progressively more emphasis on its potential as a central readout for target engagement and as a (translational) functional marker of neuronal circuit processes underlying normal and pathological brain functioning. In a similar vein as was done for human p-EEG studies, the contribution of animal p-EEG studies can further benefit by adherence to guidelines for methodological standardization, which are presently under construction by the International Pharmaco-EEG Society (IPEG).

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Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia

Cited by 11 publications

References 65 publications

N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth

N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

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