Histological, cytogenetic and endocrine evaluation in twenty-five unilateral cryptorchid horses

Vilar, Jose M. G.; Batista, M.; Carrillo, José M.; Rubio, Mónica; Sopena, Joaquín; Alamo, D

doi:10.1080/09712119.2017.1333435

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…These changes are more pronounced in abdominal than in inguinal testes. 56,59,60 Severe testicular compromise following torsion of the spermatic cord may lead ischemia, 59,61,62 tissue necrosis and atrophy, which may sometimes be confused with true monorchidism, a much less common condition. [63][64][65][66][67] Histochemical studies of cryptorchid testes revealed a disruption of the morphology and histochemistry of both Leydig and Sertoli cells.…”

Section: Histopathology Of Retained Testismentioning

confidence: 99%

“…Other neoplasms reported in undescended testes including carcinomas, 53 interstitial cell tumors, 71,84 malignant Sertoli cells tumors, 85 and leiomyosarcoma. 86 Horses with abdominal retention of a testis may sometimes present with an acute abdomen (colic) due to torsion of the spermatic cord 61 or jejunal entrapment and strangulation. 73,87…”

Section: Histopathology Of Retained Testismentioning

confidence: 99%

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Cryptorchidism in stallions

Arroyo

Tibary

2023

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Cryptorchidism is the most common disorder of sexual development in the male. The etiopathogenesis of cryptorchidism remains poorly understood and may involve genetic and environmental factors. The condition is obvious in horses with a good history, but diagnosis of cryptorchidism can be challenging in an apparently gelded horse presenting with stallion-like behavior and hemicastrated horses. Determination of the location of the retained testis is important for the selection of the surgical approach for cryptorchidectomy. The objective of this paper is to review current knowledge regarding pathogenesis of cryptorchidism in the equine, and methods for diagnosis including ultrasonographic determination of the location of the retained testis. A discussion of cryptorchidectomy approaches and possible complications is presented.

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Section: Histopathology Of Retained Testismentioning

confidence: 99%

Section: Histopathology Of Retained Testismentioning

confidence: 99%

Cryptorchidism in stallions

Arroyo

Tibary

2023

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“…The blood samples destined for chromosomical and cytogenetic analyses were collected in both 10 mL tubes without anticoagulant and lithium-heparinized tubes, placed in a container at a temperature of 5 • C, and sent to the cytogenetics laboratory of the Department of Veterinary Medicine and Animal Production of the Federico II University of Naples. The concentration of serum testosterone (T) was determined using a solid-phase I125 radioimmunoassay (Coat-A-Count Testosterone ® , Siemens, Camberley, UK), as described by Vilar et al [36]. The assay sensitivity was of 0.05 ng/mL, and the interassay coefficient of variation was 13.9%.…”

Section: Hormonal Analysismentioning

confidence: 99%

An Unusual Case of Testicular Disorder in Sex Development of Arabian Mare (64,XX SRY-Negative)

Peretti

Satué

Ciotola

et al. 2020

Animals

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A 3-year-old Arabian mare underwent medical examinations due to the presence of abnormalities of the reproductive apparatus and stallion behavior (nervous temperament, aggressiveness, masculine attitude). During the clinical visit, an anovulvar distance shorter than normal was observed; moreover, vulvar lips were dorsally fused except for the lower neckline, showing a blind ending from which a penis-like structure protruded. The ultrasound examination revealed the presence of a cervix and corpus of a uterus, hypoplastic uterine horns, and small gonads with an echogenicity similar to a testis. Blood testosterone levels ranged from 0.4 to 0.6 ng/mL. Cytogenetic analysis showed a normal female karyotype (2n = 64,XX), while PCR amplification of SRY and ZFY genes revealed the absence of a Y chromosome. At necroscopic examination, internal genitalia arising from the genital ridge in the form of masculine type structures were found, while those deriving from the Mullerian ducts were of feminine type. In addition, an infundibular portion of the salpinx at the cranial pole of the gonads was found. This is the first case in equine species of DSD 2n = 64,XX SRY-negative, with the simultaneous presence of male (hypoplastic testicles, epididymal portions, and a penis-like structure) and female (cervix, horn and body of a hypoplastic uterus) genital structures.

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“…Incidence of perioperative and postoperative complications ranged from 10.0-60.0% according to surgical procedure or postoperative management [5][6][7][8][9][10][11]. Indwelling testis in the abdomen of cryptorchid equids can still produce testosterone [12], which may contribute to unwanted behavior. Laparotomy or laparoscopic surgery must be performed to remove the testis from cryptorchid animals.…”

Section: Introductionmentioning

confidence: 99%

GnRH Vaccine could Suppress Serum Testosterone in Stallion Mules

Khumsap,

Tangtrongsup,

Towiboon

et al. 2024

Preprint

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Stallion mules have been used as working equids in several countries. Aggressiveness, under the influence of testosterone, resulted in the necessity for surgical castration before work training. The gonadotropin-releasing hormone (GnRH) vaccine may be an alternative method for immunocastration in mules. The objectives were to evaluate the effect of GnRH vaccine on anti-GnRH antibody production, serum testosterone level, clinical adverse effects, and behavior toward human manipulation. Twenty-five mules were separated into 3 groups: Control-intact, Control-castrated, and Treatment. Treatment was further divided into subgroups according to condition (intact or unilateral cryptorchid) and age. Treatment received 195 µg GnRH vaccine intramuscularly at week 0, 4, and 8. Anti-GnRH antibody increased at week 6 and 10, then gradually decreased to baseline at week 22. Treatment-intact-young had the highest anti-GnRH antibody, resulting in lower serum testosterone levels during week 2-6 and 12-16 compared to Control-intact. Subcutaneous edema adjacent to the injection site was detected only in Treatment-intact after booster vaccination. During week 6-22, the behavioral scores of Treatment significantly changed toward at ease with human contact compared to a score before vaccination. In conclusion, mules responded to GnRH vaccine, which could temporarily suppress testosterone for up to 16 weeks.

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Histological, cytogenetic and endocrine evaluation in twenty-five unilateral cryptorchid horses

Cited by 6 publications

References 16 publications

Cryptorchidism in stallions

Cryptorchidism in stallions

An Unusual Case of Testicular Disorder in Sex Development of Arabian Mare (64,XX SRY-Negative)

GnRH Vaccine could Suppress Serum Testosterone in Stallion Mules

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