Histological dating of timed endometrial biopsy tissue is not related to fertility status

Coutifaris, Christos; Myers, Evan R.; Guzick, David S.; Diamond, Michael P.; Carson, Sandra Ann; Legro, Richard S.; McGovern, Peter G.; Schlaff, William D.; Carr, Bruce R.; Steinkampf, Michael P.; Silva, Sílvia Agostinho da; Vogel, Donna L.; Leppert, Phyllis C.

doi:10.1016/j.fertnstert.2004.03.069

Cited by 326 publications

(160 citation statements)

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“…The histological maturation of the endometrium develops in a distinct pattern that follows the progression of the menstrual cycle. Recently, on a large number of women, it was demonstrated that histological dating of the endometrium does not have the accuracy or the precision necessary for the diagnosis of luteal phase deficiency, or to guide clinical management of women with reproductive failure [26,27]. It was proposed that the dating of endometrium should be related to the serum LH surge, which corresponds to ovulation, rather than to the "ideal" 28-day cycle [28].…”

Section: Endometrial Dating and The Window Of Implantationmentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

140

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Embryonic implantation is a dynamic process of paracrine interactions between the maternal compartment and the conceptus and involves a receptive endometrium and a developmentally competent blastocyst. Herein, we review histology, clinical approaches, and the promise of transcriptomics in elucidating mechanisms underlying implantation and development of biomarkers of uterine receptivity -with an eye to diagnose and treat implantation-based disorders of miscarriage, fetal growth restriction, pre-eclampsia, and infertility.Keywords human implantation; endometrium; microarray; blastocyst Challenges and approaches in studying the process of human implantation Clinical implicationsSuccessful embryo implantation is a crucial event in natural and assisted human reproduction. Blastocyst implantation is a dynamic process, involving embryo apposition, attachment to the maternal endometrial epithelium, and invasion into the endometrial stroma [1]. With in vitro fertilization (IVF), implantation failure can occur due to several factors [2], including embryonic defects such as chromosomal abnormalities, which are the most common cause of implantation failure [3,4]. Another widely acknowledged barrier to successful blastocyst implantation and, therefore, successful treatment of infertile women with implantation failure, is an inappropriately developed endometrium. It is well established that embryos cannot implant in a poorly matured endometrium [5], and this may be responsible for low implantation rates with transfer of "good quality" embryos. The success of embryonic implantation further relies upon cross-talk between the embryo and a receptive endometrium [5]. Optimization of IVF results are important for many reasons, and achieving optimal implantation is even more important in the setting of single embryo transfer, a common practice aimed to avoid multiple pregnancies.Corresponding author: Linda C. Giudice, MD, PhD, MSc, Professor and Chair, Department of Obstetrics, Gynecology and Reproductive Sciences, The Robert B. Jaffe, MD Endowed Professor in the Reproductive Sciences, University of California, San Francisco, 505 Parnassus Ave., M1496, Box 0132, San Francisco, CA 94143-0132, Tel: +1 4154762564, Fax: +1 415476181, giudice@obgyn.ucsf.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The implantation window and challenges of studying it NIH Public AccessThe endometrium is receptive to blastocyst implantation during a spatially and temporally restricted "window", when the luminal epithelium is favorable for blastocyst implantation even in the absence of an implanting ...

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Section: Endometrial Dating and The Window Of Implantationmentioning

confidence: 99%

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Aghajanova¹,

Hamilton²,

Giudice³

2008

Seminars in Cell & Developmental Biology

140

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“…13,14 Still another study evaluated the ability of histological dating to discriminate between fertile and infertile couples, according to this study the utility of histological dating of endometrium in the evaluation of infertile couples is uncertain. 15 Singh N, et al in their prospective studied evaluated the role of endometrial thickness, pattern & sub endometrial blood flow measured by 2D power Doppler ultrasound They concluded that thin endometrium with non-tripleline in IVF-ICS candidate cryopreservation was recommended and that vascularity has useful predictive value on the implantation rate in IVF cycle irrespective of morphological appearance of endometrium. 16 In studies it was seen that endometrial and sub endometrial blood flow according to Doppler USG in women undergoing ART could not predict endometrial receptivity and IVF outcome.…”

Section: Discussionmentioning

confidence: 99%

To study the correlation of mid-cycle luteinizing hormone surge, endometrial thickness and blood flow with histopathological finding of premenstrual endometrial biopsy in patient undergoing evaluation for infertility

Gupta

Shekhar

2016

Int J Reprod Contracept Obstet Gynecol

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“…It is well known that, embryo quality as well as embryo development synchronism with endometrial receptivity are important factors that can affect pregnancy rates in IVF cycles (Coutifaris et al, 2004;Loutridis et al, 2008). Recent studies in animals and humans suggest that ovarian hyperstimulation, an important part of the IVF procedures, can lead to several alterations in the endometrium, such as epithelium depth, the number and length of microvilli, the mitotic activity on the epithelial interface with stromal cells, and decreased number of specific integrins associated with the implantation window (Chen et al, 2007;Al-Ghamdi et al, 2008;Weinerman & Mainigi, 2014).…”

Section: Discussionmentioning

confidence: 99%

Vitrification of Human Oocytes and its Contribution to In Vitro Fertilization Programs

Almodin

Ceschin²,

Nakano

et al. 2015

JBRA Assisted Reproduction

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Objeticve: To study the cumulative pregnancy outcome, particularly in terms of live births, with the consecutive transfer of embryos from fresh and vitrified/warmed oocytes to infertile patients in a routine infertility program. Methods: Patients were initially submitted to in vitro fertilization embryo transfer with fresh embryos, while surplus oocytes were vitrified with the Vitri-Ingá method. Patients who did not succeed to carry their gestation to term underwent a new cycle with embryos from their own warmed oocytes. Some of the patients participating in the first warming cycle, who still possessed surplus oocytes, underwent a second warming cycle. Clinical and pregnancy outcomes obtained with fresh and warming cycles were compared using the chi-square test at a level of significance of 5%. Results: Of the 211 participating patients, 97 (46%) got pregnant with fresh embryo transfer, and 69 (32.7%) carried their pregnancies to term. Of the patients participating in the first and second warming cycles, 32/100 (32%) and 6/20 (30.0%) resulted in live births, respectively. Thus, of the 211 participating patients, 107 carried their pregnancies to term, representing a cumulative live birth rate of 50.7%. No statistically significant differences between the use fresh and vitrified oocytes were found for any of the variables studied. Conclusions: Oocyte vitrification offered the possibility of gestation in more than one attempt after just one controlled hyperstimulation. Apart from alleviating the financial burden on patients, vitrification of oocytes may result in a feasible solution for the problems generated by abandoned frozen embryos.

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Histological dating of timed endometrial biopsy tissue is not related to fertility status

Cited by 326 publications

References 39 publications

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

Uterine receptivity to human embryonic implantation: Histology, biomarkers, and transcriptomics

To study the correlation of mid-cycle luteinizing hormone surge, endometrial thickness and blood flow with histopathological finding of premenstrual endometrial biopsy in patient undergoing evaluation for infertility

Vitrification of Human Oocytes and its Contribution to In Vitro Fertilization Programs

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