Histological diagnosis of chronic inflammatory bowel disease in childhood.

Chong, Sonny K. F.; Blackshaw, A.J.; Boyle, S.; Williams, Christopher; Walker-Smith, J A

doi:10.1136/gut.26.1.55

Cited by 113 publications

(64 citation statements)

References 5 publications

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“…The diagnosis of IBD was based on clinical, radiological, endoscopic and histological features [11, 14, 15]. Mail-in questionnaires were then completed by the physicians who made the original diagnosis.…”

Section: Methodsmentioning

confidence: 99%

“…All new pediatric cases were subcategorized into the following clinical groups: definite CD (dCD); probable CD (pCD); definite UC (dUC); probable UC (pUC), and IC [working document: Jenkins H: Clinical and diagnostic criteria to be used in the epidemiology of IBD, ESPGHAN Working Group on Pediatric IBD Epidemiology, Taormina, Sicily, Italy, June 2002, unpublished data]. CD, UC and IC were defined according to established clinical, endoscopic, radiological, and histological criteria [14, 15]. Definite CD was defined as the presence of discontinuous chronic inflammation of the gastrointestinal tract, confirmed by characteristic histological features [14, 15], supported by clinical, endoscopic and sometimes radiological evidence of CD.…”

Section: Methodsmentioning

confidence: 99%

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Epidemiology of Inflammatory Bowel Disease among Children in Poland

et al. 2009

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Background/Aims: The incidence of pediatric inflammatory bowel disease (IBD) in Western countries is on the rise. No prospective studies have been conducted on the epidemiology of pediatric IBD in Poland. The aim of the study was to define the characteristics of new pediatric IBD and assess the incidence of new IBD among children in Poland between 2002 and 2004. Methods: Patient records from 24 pediatric gastroenterology centers servicing the whole population of Poland were collected. IBD diagnosis was based on clinical, radiological, endoscopic and histological features. Results: There were 491 new IBD patients, representing an overall incidence of IBD of 2.7 cases/100,000 children/year. The incidence of Crohn’s disease (CD) was 0.6, ulcerative colitis (UC) 1.3, and indeterminate colitis (IC) 0.8. The age-related incidence of IBD was 1.8 in the 0- to 10-year-old age group, rising to 3.7 for the 11- to 18-year age group. Conclusions: The overall incidence of IBD (as well as CD, UC and IC) in Poland is lower than that in Western countries. The relative contribution of UC and IC to the overall IBD incidence is higher in Poland than in most Western countries. These findings may suggest a tendency towards under- or misdiagnosis.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Epidemiology of Inflammatory Bowel Disease among Children in Poland

et al. 2009

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“…None of these children has subsequently developed IBD and all are healthy. Clinical diagnosis was based on the criteria of Chong et al (1985).…”

Section: Methodsmentioning

confidence: 99%

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

MacDonald

Hutchings

Choy

et al. 1990

Clinical and Experimental Immunology

433

110

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SUMMARY The spot‐ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor‐alpha (TNF‐α) and interferon‐γ (IFN‐γ), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF‐α production was undetectable in six out of 12 biopsies from normal intestine and in the other six biopsies it ranged from 60 to 580 TNF‐α‐secreting cells/106 isolated intestinal cells. In contrast, cells isolated from biopsies of children with Crohn's disease (n= 9) all showed elevated frequencies of TNF‐á‐secreting cells (500–12 000 secreting cells/106 cells). In ulcerative colitis, four out of eight children had increased production of TNF‐α and in children with indeterminate colitis two out of three had elevated levels. There was no correlation between plasma TNF‐α levels and the number of intestinal cells secreting TNF‐α. In controls and all groups of patients IFN‐γ‐secreting cells were uncommon. These results suggest that TNF‐α is an important mediator of inflammation in the human gut, and, furthermore, may play a role in the growth failure frequently seen in children with inflammatory bowel disease.

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“…The histological diagnosis of CD or UC was made according to the criteria of Chong et al [13]. Intestine from 19 children with active CD was studied (Table 1).…”

Section: Tissue Studiedmentioning

confidence: 99%

“…specimens, snap frozen, and stored at ÿ 708C. Ileal specimens were obtained from nine children (cases 1-9), colonic specimens from nine (cases [11][12][13][14][15][16][17][18][19], and both colonic and ileal specimens from one (case 10).…”

Section: Tissue Studiedmentioning

confidence: 99%

The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD)

Fell

Walker-Smith

Spencer

et al. 1996

Clinical and Experimental Immunology

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T cell hypersensitivity has been implicated in the tissue damage in Crohn's disease (CD). All studies to date have examined mucosal T cells, although much of the tissue damage occurs in the submucosa and muscle layers. The aim of this work was to study T cell proliferation throughout the intestinal wall in children with IBD. Surgical resection material from 19 children with CD (10 ileal, 10 colonic), seven with ulcerative colitis (UC), and 12 normal controls was studied. The distribution of dividing T cells was investigated by double‐immunohistochemistry using Ki67 to identify proliferating cells, and CD3 to identify T cells. In ileal and colonic lamina propria virtually no Ki67+, CD3+ cells were seen in control, UC or CD tissue. In contrast, there were significantly more Ki67+, CD3+ cells within the lymphoid follicles of ileal and colonic CD than in the follicles in UC and controls. Increased numbers of Ki67+, CD3+ cells were present in the submucosa, muscle layers (M) and serosa in Crohn's ileitis and colitis compared with the lamina propria (LP), although only in the muscle of the colon was the difference statistically significant (LP, 0.4% (0–1%); M, 1.6% (0–5.2%); P = 0.03). Pooling data from ileal and colonic CD, however, did show significantly increased Ki67+, CD3+ cells in both serosa and muscle layers compared with the LP. Dividing T cells have been identified in the deeper layers of the gut wall in CD. These may contribute to the fibrosis and muscle hyperplasia characteristic of the condition.

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Histological diagnosis of chronic inflammatory bowel disease in childhood.

Cited by 113 publications

References 5 publications

Epidemiology of Inflammatory Bowel Disease among Children in Poland

Epidemiology of Inflammatory Bowel Disease among Children in Poland

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD)

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