Histological differences in the adherence of connective tissue to laser-treated abutments and standard abutments for dental implants. 
An experimental pilot study in humans

Blázquez-Hinarejos, Mónica; Ayuso‐Montero, Raúl; Jm, Álvarez-López; Manzanares-Céspedes, María Cristina; López‐López, José

doi:10.4317/medoral.21949

Cited by 9 publications

(11 citation statements)

References 16 publications

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“…Histological studies in animals and humans provided evidence of reattachment of the connective tissue when a laser-microgrooved healing abutment was replaced with another laser-microgrooved healing or definitive abutment [ 19 , 21 , 23 ]. In this context, in the MS group of the current study, PD showed a statistically significant increase during the restorative phase (between T0 and T1), while in the LMS group, it remained mostly constant.…”

Section: Discussionmentioning

confidence: 99%

“…Attachment helps stabilize the peri-implant soft tissue and protect the peri-implant marginal bone. It has been also histologically documented in animal and human models that the peri-implant soft tissue seal developed using an 8-μm LMS on healing abutments can be transferred to another abutment with the same macro and micro-architecture [ 21 – 23 ]. A clinical question, however, remains unanswered: whether repeated removal and reattachment of LMS healing abutments for impression procedures and metal framework try-in disturbs and disrupts the mucosal seal.…”

Section: Introductionmentioning

confidence: 99%

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Laser microgrooved vs. machined healing abutment disconnection/reconnection: a comparative clinical, radiographical and biochemical study with split-mouth design

et al. 2021

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Background Repeated removal and replacement of healing abutments result in frequent injuries to the soft tissues. Purpose The purpose of this study was to evaluate the effect of disconnection/reconnection of laser microgrooved vs. machined healing and prosthetic abutments on clinical periodontal parameters, marginal bone levels, and proinflammatory cytokine levels around dental implants. Material and methods Twenty-four patients each received 2 implants with one-stage protocol in a split-mouth design on the same jaw. In each patient, one healing and prosthetic abutments with a laser microgrooved surface (LMS group) and one healing and prosthetic abutments with machined surface (MS group) were used. Four months following implant placement (T0), the healing abutments were disconnnected and reconnected three times to carry out the impression procedures and metal framework try-in. Four weeks later (T1), definitive prosthetic abutments were installated with screw-retained crowns. Modified plaque index (mPI), modified gingival index (mGI) bleeding on probing (BOP), and probing depth (PD) were recorded at T0 and T1. At the same time points, samples for immunological analyses were taken from the sulcus around each implant. Peri-implant crevicular fluid (PICF) samples were analyzed for interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF)-α levels using the ELISA kit. Results At T0 and T1, mPI and mGI showed no statistical difference between the two groups, while higher PD and BoP values were noted for the MS group (P < 0.05). The mean PICF volume and mean concentrations of IL-1β, IL-6, and (TNF)-α in the LMS group were statistically less than those in the MS group (P < 0.05). In addition, comparison of IL-6 and IL-1β mean concentrations at T0 and T1 in the MS group showed a statistically significant increase (p < 0.05) over time, which was not noted for the LMS. Conclusion Disconnection/reconnection of healing and prosthetic abutments with a laser-microgrooved surface resulted in less inflammatory molecular response compared with conventional machined ones. Trial registration ClinicalTrials.govNCT04415801, registered 03/06/2020

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laser microgrooved vs. machined healing abutment disconnection/reconnection: a comparative clinical, radiographical and biochemical study with split-mouth design

et al. 2021

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“…To prevent peri-implant inflammation, recent studies focused on a distinctive laser-generated microgrooved surface (LMS) in the cervical region of implants and titanium abutments. These surfaces might seal the implant against infections by building a strong connective tissue adherence and could therefore show less inflammatory activity and consequently a decrease in marginal bone loss in comparison with other abutment surfaces [20][21][22][23]. LMS surface is a highly orientated microgeometry produced by using a computer-controlled laser system.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional evaluation of clinical and immunological parameters at partially microgrooved vs machined abutments in humans

Iglhaut

Salomon²,

Fretwurst

et al. 2021

Int J Implant Dent

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Objective The objective of the present study was to examine the clinical and immunological parameters in samples collected from the peri-implant crevicular fluid (PICF) of machined titanium (M) abutments compared to titanium abutments with a laser-microtextured surface (LMS) on dental implants. Material and methods A total of 40 patients with one titanium implant, half of them (n=20) provided with a M abutment (control group) and the other half (n=20) with LMS abutments (test group), were included in the study. Clinical parameters pocket probing depth (PD), full-mouth plaque score (FMPS), radiographic bone loss (RBL), clinical attachment level (CAL), mucosal recession (MR), bleeding on probing (BOP), and width of keratinized mucosa (KM) were evaluated. The peri-implant sulcus fluid was analyzed for cytokines IL-1α, IL-1β, IL-6, IL-8, and IL-10 via flow cytometry. Results Clinical evaluation demonstrated no significant difference of PD (mean LMS = 3.50 mm/SD 0.95 mm vs mean M = 3.45 mm/SD 0.76 mm (p=0.855)), MR (mean LMS = 0.30 mm/SD 0.57 mm vs mean M = 0.35 mm/SD 0.67 mm (p=0.801)), CAL (mean LMS = 3.60 mm/SD 1.14 mm vs mean M = 3.55 mm/SD 0.89 mm (p=0.878)), and KM (mean LMS = 2.03 mm/SD 1.08 mm vs mean M = 2.13 mm/SD 0.92 mm (p=0.754)) between LMS and M abutments. LMS abutments showed less BOP than M abutments (26.7% vs 30.8%), but statistically not significant (p = 0.2235). Radiographic bone loss (mean LMS = 0.22 mm/SD 0.44 mm vs mean M = 0.59 mm/SD 0.49 mm) was reduced in the test group in comparison with the control group (p=0.016). In the collected PICF, the levels of pro-inflammatory cytokines IL-1α (median LMS = 180.8 pg/ml vs M = 200.9 pg/ml (p=0.968)) and IL-1β (median LMS = 60.43 pg/ml vs M = 83.11 pg/ml (p=0.4777)) were lower, and the levels of IL-6 (median LMS = 180.8 pg/ml vs M = 200.9 pg/ml (p<0.0001)) were significantly lower in the test group. In contrast, the levels of IL-8 (median LMS = 255.7 pg/ml vs M = 178.7 pg/ml (p=0.3306)) were higher in the test group, though not significantly. The levels of anti-inflammatory IL-10 were significantly increased in the test group (LMS median = 0.555 pg/ml vs M median = 0.465 pg/ml (p=0.0365)). IL-1β showed a significant correlation to radiologic bone loss (p=0.0024). The other variables IL-1α, IL-6, IL-8, and IL-10 had no significant correlation to radiological bone loss. Conclusion Within the limitations of this study, titanium implants provided with laser-microtextured surface abutments seem to demonstrate less pro-inflammatory and more anti-inflammatory activity and to show reduced radiographic bone loss compared to machined titanium abutments. Clinical relevance The use of laser-microtextured surface abutments might have the potential to support peri-implant tissue health.

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“…Tras estudiar estas evidencias en implantes, los autores publicamos un estudio clínico en humanos más reciente, donde evaluamos las diferencias histológicas entre los tejidos blandos alrededor de pilares lisos y pilares tratados con láser en su zona cervical (23) . En el estudio encontramos diferencias estadísticamente significativas entre el porcentaje de unión existente entre el grupo de pilares tratados con láser y el grupo de pilares sin tratamiento; y llegamos a la conclusión principal de que el tejido conectivo tiene una mejor adhesión a los pilares tratados con láser en comparación a los pilares lisos.…”

Section: Introductionunclassified

“…b) Pilar de superficie lisa. Fotografías tomadas de las muestras histológicas del estudio clínico de Blázquez-Hinarejos et al (23). .…”

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Tratamiento Laser-Lok® en implantes dentales. A propósito de un caso clínico

et al. 2021

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Uno de los retos más importantes, hoy en día, en implantología oral es evitar la pérdida ósea alrededor de los implantes oseointegrados y funcionales con el paso del tiempo. Una de las superficies que se ha desarrollado en los últimos años es la resultante de la microtexturación mediante láser. Diversos estudios han demostrado la adhesión del tejido conectivo a las superficies tratadas con láser en la zona cervical de los implantes oseointegrados, consiguiendo de este modo un sellado biológico a este nivel. Revisamos lo publicado sobre este tema y presentamos un caso clínico de inserción de un implante unitario con tratamiento láser en su zona cervical desde su colocación hasta la restauración final, donde se observa la buena integración de los tejidos y el éxito del caso a largo plazo.

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Histological differences in the adherence of connective tissue to laser-treated abutments and standard abutments for dental implants. An experimental pilot study in humans

Cited by 9 publications

References 16 publications

Laser microgrooved vs. machined healing abutment disconnection/reconnection: a comparative clinical, radiographical and biochemical study with split-mouth design

Laser microgrooved vs. machined healing abutment disconnection/reconnection: a comparative clinical, radiographical and biochemical study with split-mouth design

Cross-sectional evaluation of clinical and immunological parameters at partially microgrooved vs machined abutments in humans

Tratamiento Laser-Lok® en implantes dentales. A propósito de un caso clínico

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