Histological differential diagnosis of verruca vulgaris: A systematic review

Alaziz, Mustafa; Najim, Noor Rafid

doi:10.33545/pathol.2021.v4.i3a.385

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…This is one of the wart disorders associated with the human papillomavirus (HPV) and can be transmitted by skin-to-skin contact. Verruca vulgaris has an irregular shape and is more common in males [19].…”

Section: Verruca Vulgarismentioning

confidence: 99%

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

2024

J Med Biomed Discoveries

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Section: Verruca Vulgarismentioning

confidence: 99%

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

2024

J Med Biomed Discoveries

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“…Among these, CXCL10 (C-X-C motif chemokine ligand 10) has emerged as a molecule of interest. CXCL10 is involved in the recruitment of immune cells to the site of infection or inflammation, playing a pivotal role in the body's defence mechanism against viral infections, including HPV [4] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Gene Expression of CXCL10 in Patients with Verruca Vulgaris

2024

The Egyptian Journal of Hospital Medicine

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Background: Verruca vulgaris, a common skin condition caused by human papillomavirus (HPV), poses significant treatment challenges. Recent research has shifted towards understanding the molecular mechanisms underlying these lesions, including the role of chemokines like CXCL10 in their pathogenesis and potential as therapeutic targets.Objective: This study aimed to evaluate the expression of the CXCL10 gene in patients with verruca vulgaris and to evaluate its potential as a biomarker for disease presence and severity. Methods: A prospective case-control study that included 50 patients diagnosed with verruca vulgaris and 30 healthy controls. The study measured CXCL10 gene expression levels in verruca lesions versus healthy skin biopsies using quantitative reverse transcription PCR (qRT-PCR), following RNA extraction and cDNA synthesis. Results: The study revealed significantly higher CXCL10 gene expression in verruca lesions (3.76 ± 2.87) compared to healthy skin (1.89 ± 2.01), with a P-value of 0.008. The discriminative power of CXCL10 expression demonstrated 77% sensitivity and 60% specificity at a cutoff point of 1.339. Untreated patients showed significantly higher CXCL10 expression compared to those who received previous treatment (P = 0.031). Conclusion: CXCL10 was significantly upregulated in verruca vulgaris lesions, highlighting its potential as a biomarker for the condition. The lack of correlation with lesion duration or size suggests CXCL10's role is more closely associated with the presence rather than the severity of the disease. The observed reduction in CXCL10 expression following treatment may open new avenues for targeted therapeutic strategies.

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Overcoming Giant Verruca Vulgaris Treatment Obstacles With Siddha Medicine: A Case Report

Johnson,

Karan Chand Mohan Singh,

Murugan

et al. 2024

Cureus

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Verrucae vulgaris are infectious keratotic lesions caused by the human papillomavirus (HPV), frequently impairing an individual's quality of life, mainly when situated on the facial region. Verruca vulgaris constitutes a prevalent dermatological issue with diverse repercussions for those affected. The interaction among HPV, the immune system, and treatment methods requires a sophisticated comprehension of this illness. The need for more proficient management of this ailment constitutes a considerable challenge for the healthcare industry. Topical corticosteroids, cryo-therapeutic techniques, laser-based treatments, and immunotherapeutic modalities, including photodynamic therapy, are recognized as costly alternatives. Siddha external medicine offers a therapeutic strategy that employs suitable methodologies. This case report elucidates the clinical presentation of a 60-year-old female exhibiting hyperkeratotic, elevated, non-painful growth lesions localized to the left malar region, which have persisted for six years. She was diagnosed with giant facial verrucae vulgaris based on the observed clinical manifestations. The patient received external therapeutic intervention utilizing Siddha medicine, particularly applying pachaieruvai. The intervention resulted in the complete excision of the lesion, yielding aesthetically pleasing outcomes without any adverse reactions or recurrence observed during subsequent follow-up assessments.

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Histological differential diagnosis of verruca vulgaris: A systematic review

Cited by 3 publications

References 31 publications

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

PANIS Method: A Cutting-Edge Approach for Lid Margin and Periocular Benign Lesions

Evaluation of the Gene Expression of CXCL10 in Patients with Verruca Vulgaris

Overcoming Giant Verruca Vulgaris Treatment Obstacles With Siddha Medicine: A Case Report

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