Histological Differentiation of Primary Oral Squamous Cell Carcinomas in an Area of Betel Quid Chewing Prevalence

Fang, Ku‐Hao; Kao, Huang‐Kai; Cheng, Ming-Hui; Chang, Yu‐Cheng; Tsang, Ngan‐Ming; Huang, Yu‐Chen; Lee, Li‐Yu; Yu, Jau‐Song; Hao, Sheng‐Po; Chang, Kai‐Ping

doi:10.1016/j.otohns.2009.09.012

Cited by 39 publications

(30 citation statements)

References 22 publications

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“…An elevated score is a risk factor for long-term outcomes and is associated with high overall stage, ENE, perineural invasion, and tumor depth. According to our previous studies, ENE, cell differentiation, and perineural invasion have been demonstrated as important prognostic factors 25–27 . Consequently, the ANS, incorporated with TNM stage, age, sex, ENE, cell differentiation, and perineural invasion, was constructed as this prognostic nomogram to predict OS.…”

Section: Discussionmentioning

confidence: 92%

Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma

Kao

Löfstrand

Loh

et al. 2018

Sci Rep

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Increasing evidence indicates that inflammation plays a crucial role in cancer development. A novel scoring system based on albumin and the neutrophil-to-lymphocyte ratio (NLR) was developed and incorporated into a nomogram to create a more accurate prognostic tool for oral cavity squamous cell carcinoma (OSCC) patients. A retrospective review was performed on 613 consecutive patients undergoing ablative surgery for OSCC between September 2005 and December 2014. NLR and albumin were determined and used to calculate an albumin/NLR score (ANS). The nomogram was based on the ANS and several clinicopathological manifestations, and its accuracy was determined by the concordance index (c-index). A high ANS was significantly associated with aggressive tumor behaviors, such as T status, overall stage, extranodal extension, perineural invasion, tumor depth, and decreased overall survival (OS). Multivariate analysis indicated that age, overall stage, extranodal extension, and ANS were independent factors for OS. The c-index for OS prognosis was 0.750 using this nomogram compared to 0.688 using TNM staging alone. The prognostic accuracy for OS in OSCC patients can be significantly improved using a nomogram that incorporates the novel ANS and other clinicopathological variables.

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Section: Discussionmentioning

confidence: 92%

Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma

Kao

Löfstrand

Loh

et al. 2018

Sci Rep

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“…This observation coincides with the findings of authors Fang and Kao who also observed fewer incidences of poorly differentiated lesions (8%) in their study conducted on 150 primary oral squamous cell carcinomas. [21]…”

Section: Discussionmentioning

confidence: 99%

Estimation of plasma lipids and its significance on histopathological grades in oral cancer: Prognostic significance an original research

Sherubin

Kannan

Kumar

et al. 2013

J Oral Maxillofac Pathol

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Background Objectives:Alterations in the lipid profile have long been associated with various cancers because lipids play a key role in maintenance of cell integrity. This study was to estimate the plasma lipid levels in patients with oral cancer and to correlate the values with the histopathological grades.Materials and Methods:The study group included 50 patients with oral cancer aged between 20 and 60 years who had visited the Department of Oral Medicine and Radiology during the period of September 2005 to July 2007. After the histotopathological confirmation, their plasma lipid levels were estimated using auto analyzer and the data was statistically analyzed.Results:The study revealed a significant decrease in the total plasma lipid levels in patients with oral cancer in comparison with the standard values. Comparing the plasma lipid levels with the histopathological grades, we observed a significant variation in the levels of total cholesterol, very low density lipoprotein, low-density lipoprotein, high-density lipoprotein and triglyceridesConclusion:The variation in the levels of plasma cholesterol and other lipid constituents in patients with cancer might be due to their increased utilization by neoplastic cells for new membrane biosynthesis. This study was an attempt to estimate the plasma lipids in oral cancer patients and its significance on histopathological grades. We observed a relationship between lower plasma lipids and oral cancer. The result of our study strongly warrants an in-depth research with larger samples and a longer follow-up to consider the low plasma lipid status in oral cancer patients as a useful indicator to assess the course and prognosis of the disease.

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“…Patients with pathologic evidence of multiple neck lymph node metastasis and/or extracapsular spread received concurrent adjuvant chemoradiotherapy (a cisplatin-based regimen plus a total radiation dose of 66 Gy given as 1.8-2 Gy per day for 5 days per week). After discharge, all patients had regular follow-up visits every 2 months for the first year, every 3 months for the second year, and every 6 months thereafter [45, 46]. …”

Section: Methodsmentioning

confidence: 99%

ASC contributes to metastasis of oral cavity squamous cell carcinoma

Chang

OuYang

et al. 2016

Oncotarget

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ASC (Apoptosis-associated Speck-like protein containing a CARD) acts as a platform protein in the inflammasome cascade of some cancer types. However, its potential involvement in OSCC (oral cavity squamous cell carcinoma) has not yet been determined. Here, we investigated the potential role of ASC in OSCC. RT-qPCR analysis of 20 paired tumor and adjacent normal tissue samples revealed that the mRNA levels of ASC, along with IL-1β, CASP1, and NLRP3 in ASC-associated NLRP3 inflammasome were significantly elevated in OSCC tissues. Immunohistochemical staining of these four proteins in 111 clinical specimens revealed that high-level expression of ASC was significantly associated with tumor stage, node stage (p=0.001), overall stage (p<0.001), extracapsular spread (p<0.001), perineural invasion (p=0.004) and tumor depth (p<0.001). Kaplan-Meier survival analysis further revealed that high-level ASC expression was correlated with poorer overall survival (p=0.001), disease-specific survival (p<0.001) and disease-free survival (p<0.001). Studies using OSCC cell lines indicated that high-level ASC expression enhanced cell migration and invasion, and experiments using an orthotropic nude mouse model confirmed that ASC overexpression induced metastasis of OSCC cells. This is the first report to show that ASC contributes to OSCC metastasis, and that high-level ASC expression is a marker for poor prognosis in OSCC patients.

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Histological Differentiation of Primary Oral Squamous Cell Carcinomas in an Area of Betel Quid Chewing Prevalence

Cited by 39 publications

References 22 publications

Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma

Nomogram based on albumin and neutrophil-to-lymphocyte ratio for predicting the prognosis of patients with oral cavity squamous cell carcinoma

Estimation of plasma lipids and its significance on histopathological grades in oral cancer: Prognostic significance an original research

ASC contributes to metastasis of oral cavity squamous cell carcinoma

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