Histological Effects of Formaldehyde Inhalation on the Alveolar Architecture of Lungs of Albino Rats

Abstract

Introduction: Formaldehyde is a flammable, colourless, reactive, readily polymerized gas at normal room temperature and pressure. Formaldehyde vapour is readily absorbed from the lungs. Formaldehyde is combined with methanol and buffers to make embalming fluid. In the dissection hall, during embalming or cadaveric dissection and histo-pathological preservation, medical professionals are exposed to formaldehyde vapours. Respiratory system is the major target of formaldehyde. So, the present study aims to assess the histological changes on the architecture of alveoli of albino rats after inhalation of formaldehyde vapours. Material & Methods: 24 albino rats were exposed to formaldehyde vapours for 28 days. They were exposed with various concentrations and thus 4 groups, having 6 rats in each, were made. They were sacrificed and the lung tissue was taken and studied by using H & E stain. Results: The study shows a number of important histological changes which are concentration dependent. Conclusion: It may be concluded from the present study that concentration of formaldehyde can affect significantly on the histopathology of the lungs of albino rats.