Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).

Odigie, Efosa Bolaji

doi:10.9790/3008-0561419

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…represent by necrotic in the kidneys and liver. The present study, there were degenerative changes in the kidney as vacuolated/dilated cortical tubules and vacuolation of cell lining, fibrosis and foci of inflammatory cells in the liver, but the changes in kidney and liver not progress to necrosis as reported(13) in rats (14). reported significant histopathological changes in the kidney of treated rats with sulfonamide, represent by of slight degenerative in the renal parenchyma, but no mention of any change in liver of treated rat,(14) agreed with the present study in respect of degenerative changes in the kidneys of treated pigeons with sulfonamide.…”

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confidence: 64%

“…(12) reported case report of hepatotoxicity, in this paper entitled sulfonamide hepatic injury. (13) studied the histological effects of pre-exposure prophylactic consumption of sulfa drugs on liver and kidney of albino wister rats (rattus novergicus). (14) reported that sulfonamide treatment of rat gave significant histopathological changes in the kidney of rats.…”

Section: Introductionmentioning

confidence: 99%

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The Sulfonamide Exposure and the Histopathological Alterations of Domestic Pigeon

Saleh¹,

Bahaa.²,

Isra³

et al. 2014

Bas.J.Vet.Res.

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A two months Toxicologicl pathology study of sulfonamide in domestic pigeons by oral intubation were done. The study was done at two dosage levels as intermediate 40mg/kg and high 80mg/kg with untreated control as third group. Clinical observation of treated birds did not show significant changes only the birds appeared to be quite after dosing for short time. Grossly, no obvious changes could be detected. Microscopically, Showed histopathological changes in pigeons represent of nephrotoxic effects characterized by degenerate and/or dilated cortical tubules in intermediate while, high dose groups appeared glomerular atrophy some with dilated Bowmans space, the severity of the changes were higher in the high dose group. In liver, peri portal and septal fibrosis in treated groups, some with parenchymal foci of inflammatory cell and vaculation of hepatocytes, while in pancreas, there was degenerate vacuolated islets of Langerhans in both treated groups, also in brain vacuolation of neurons and vacuoltion of nerve fiber in white matter of spinal cord. The severity of all above changes were higher in high dose than intermediate dose. Finally , the present study showed that domestic pigeons can tolerate varying toxic levels of sulfonamide with no mortality.

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confidence: 64%

Section: Introductionmentioning

confidence: 99%

The Sulfonamide Exposure and the Histopathological Alterations of Domestic Pigeon

Saleh¹,

Bahaa.²,

Isra³

et al. 2014

Bas.J.Vet.Res.

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“…These results were compatible with the present study except we detected irreversible injuries like tubular necrosis in high dose administration (30 and 70 mg), and also, in our study, embryos received a single dose of sulfadiazine. Odigie [14] investigated the morphological alteration of visceral organs (kidney and liver) of albino Wister rats pre-exposed to prophylactic consumption of sulfonamide based drugs. Histological findings indicated that oral treatment by 3 and 4 mg drug for 21 days caused infiltration of inflammatory cells, congestion 4 Zahedan J Res Med Sci.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Evaluation of Dose Dependent Sulfadiazine-Associated Nephrotoxicity and Alteration on Oxidative Stress in Chicken Embryos

Sayrafi

Golshahi

Araghi

et al. 2016

Zahedan J Res Med Sci

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Background: Numerous epidemiological and experimental researches indicate that in utero exposure to some environmental chemicals and prescribed drugs during pregnancy can mediate various embryonic abnormalities and complications via reactive oxygen species (ROS) generation, which damages cellular macromolecules. Objectives: The aim of the present study was to evaluate the sulfonamide-associated nephrotoxicity with possible underlying mechanisms in chicken embryo. Materials and Methods:In this experimental study, one hundred fertile eggs were obtained and divided into five groups: 1) control group (without injection), 2) group injected with 2 mg sulfadiazine, 3) group injected with 10 mg sulfadiazine, 4) group injected with 30 mg sulfadiazine and 5) group injected with 70 mg sulfadiazine. After hatching, the renal tissue from the newly hatched chick was harvested for histopathologic investigation and also measurement of oxidative stress parameters [the ferric reducing capacity assay, the glutathione content (GSH) and the situation of lipid peroxidation (LPO)] by spectrophotometer. Results: Histologic examination of the renal tissue revealed that sulfadiazine induces hydropic degeneration, tubular necrosis, glomerular and tubular atrophy, formation of hyaline cast, congestion, hemorrhage, interstitial nephritis and fibrosis. Conclusions: Result showed the dose-dependent administration of sulfadiazine significantly altered the histopathologic structure of renal tissues of chickens. Furthermore, the major histopathologic events in the course of sulfadiazine cytotoxicity are renal tubule epithelial cell necrosis, interstitial nephritis and fibrosis, formation of hyaline cast and congestion and hemorrhage, although sulfadiazine at dose 30 mg and 70 mg caused perturbation in antioxidant defense system by marked increase in LPO, and decrease in GSH.

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“…[6] In response to the ongoing, it is important to examine the side effects that may be associated with the indiscriminate consumption of SJ as treatment option, which is administered as a self-prescribing herbal therapy without a safe-dose regimen, and may also be without a standard preparatory procedure. [11,12] Consequently, with respect to the multifunctional morphological makeup of the liver and kidney as well as the testes (for sexual performance and enhancement); it becomes imperative to censoriously examine these specialized organs that is constantly being exposed to an indiscriminate intake / or prophylactic abuse of herbal preparations too frequently. [11] In view of the numerous works thought to have been carried out on the biochemical, haematological, phytochemical, histological and acute toxicity studies [1, 2, 5 & 6] ; there remains a dearth of literature on the histopathological effects resulting from the prophylactic consumption of the ethanolic root extract of SJ on some organs of interest (liver, kidney and teste) in this study.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Effects of Prophylactic Consumption of Sphenocentrum Jollyanum (SJ) Ethanolic Root Extract on Select Organs of Male Albino (Rattus novergicus) Rats

Atoigwe¹,

Achukwu²,

Odigie³

2016

AIMDR

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Variations in the arterial pattern of the upper limb are very common as observed in many cadaveric and angiographic studies. Knowledge of variations in the origin and course of the radial artery is important because they are used for many diagnostic procedures as well as vascular and reconstructive surgeries like coronary angiography, percutaneous coronary intervention and coronary artery bypass surgery. During routine dissection in our institute, we observed a case of high origin of the radial artery in a 33 year old male cadaver. It was found to be unilateral; on left side, radial artery was taking origin from 3 rd part of the axillary artery at the lower border of pectoralis minor before the origin of subscapular artery and anterior circumflex humeral artery. It had a superficial course in the arm crossing the median nerve from medial to lateral side. The further course of this superficial radial artery in the forearm was normal and it terminated by forming a deep Palmar arch in hand. These variations may be of great clinical implications for vascular and plastic surgeons and radiologists. Superficial course of radial artery makes it vulnerable to accidental injuries and elevates the risk of bleeding.

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Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).

Cited by 3 publications

References 10 publications

The Sulfonamide Exposure and the Histopathological Alterations of Domestic Pigeon

The Sulfonamide Exposure and the Histopathological Alterations of Domestic Pigeon

Histopathological Evaluation of Dose Dependent Sulfadiazine-Associated Nephrotoxicity and Alteration on Oxidative Stress in Chicken Embryos

Histopathological Effects of Prophylactic Consumption of Sphenocentrum Jollyanum (SJ) Ethanolic Root Extract on Select Organs of Male Albino (Rattus novergicus) Rats

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