Histological evaluation of follicular delivery of arginine via nanostructured lipid carriers: a novel potential approach for the treatment of alopecia

Abstract

The use of lipidic nanoparticles can overcome the limitations of skin penetration of hydrophilic charged materials. Oleic acid as an ion pairing agent was used to enhance the encapsulation of positively charged arginine into lipophilic nanostructured lipid carrier (NLC). Histological study on the male hamsters was performed to assess the efficiency of drug delivery on hair growth. The accumulation of NLCs in the hair follicles was verified and in vivo studies showed more new hair follicle growth by utilizing arginine-loaded NLCs than arginine aqueous solution. It was concluded that employing ion pairing agent could enhance drug encapsulation into NLCs structure.

Effects of a Combination of Arginine Silicate Inositol Complex and a Novel Form of Biotin on Hair and Nail Growth in a Rodent Model

“…Eflornithine, an ODC enzyme inhibitor, is used to treat hirsutism [ 38 ], while silica has also been demonstrated to increase epidermal ODC activity [ 39 ]. There is an opinion in the literature that the administration of arginine in nanotechnological lipid transporters to the hair follicle may be used to treat alopecia [ 40 ]. These findings suggest that ASI prolonged the anagen phase through growth factors and thereby increased hair density and anagen hair percentages.…”

Preparation, Optimization, and Evaluation of Methoxy Poly(ethylene glycol)-co-Poly(ε-caprolactone) Nanoparticles Loaded by Rivastigmine for Brain Delivery

“…Since Riv is a hydrophilic drug, the influence of various formulation additives on drug EE was investigated. Based on the previously published works − and our preliminary studies, OA was selected as an additive. Based on the preliminary experiments, three influential factors were chosen as the variables to be investigated (Table ).…”

Current Advances in Lipid Nanosystems Intended for Topical and Transdermal Drug Delivery Applications

“…Targeting specific cells, such as epithelial stem cells and melanocytes involved in regeneration and pigmentation, may be possible by delivering particles through hair follicles. Of course, particle size has a significant impact on penetration [ 43 ]. Ladenman et al demonstrated that nanoparticles with a size of 320 nm had significantly greater penetration into hair follicles than nonparticulate substances of the same molecular size [ 44 , 45 ].…”

“…Ladenman et al demonstrated that nanoparticles with a size of 320 nm had significantly greater penetration into hair follicles than nonparticulate substances of the same molecular size [ 44 , 45 ]. Additionally, it has been shown that hair follicles can store drugs for a long time and allow them to enter the body faster than other pathways [ 43 ]. This suggests that some submicron particles can penetrate and accumulate more efficiently than larger particles.…”