Histological Evaluation of Local Application of Flavonoid Extract of Capparis Spinosa on Wound Healing in Alloxan-Induced Diabetic Rats

Alwan, Maryam Hameed; Ghani, Ban A.

doi:10.26505/djm.18014700609

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…It also has anti-inflammatory qualities by reducing cytokine synthesis and the action of cytokines on leukocytes. According to several studies, pentoxifylline is useful in avoiding aphthous ulcers [Sridhar T et al, 2015;Alwan M, ghani B, 2020;Bondarev A et al, 2022].…”

Section: Discussionmentioning

confidence: 99%

Association Between Caffeine, Anxiety and the Occurrence of Aphthous Stomatitis in the Armenian Ethnicity

Absoian,

Hameed Alwan

2023

NAMJ

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Introduction: Aphthous stomatitis is a recurring oral ulceration condition that affects a significant proportion of the population. While several factors have been proposed to contribute to its occurrence, the link between caffeine consumption, anxiety levels, and the development of aphthous stomatitis remains unknown. This survey-based study aimed to understand the association between coffee, anxiety, and the development of aphthous stomatitis in this specific demographic, which can provide useful insights for medical management as well as preventive strategies. Material and methods: A structured online questionnaire was distributed via various social media platforms targeting a sample of the Armenian population. The questionnaire collected information on participants’ demographics, coffee use patterns, anxiety levels as measured by perceived stress scales, and the occurrence of aphthous stomatitis. Statistical analyses, including Kendall’s tau, were carried out to investigate the relationships. Results: The results revealed a significant negative association between caffeine consumption and the occurrence of aphthous stomatitis among Armenian individuals Kendall’s tau-b (τb) correlation - 240* (p<0.05). Participants who reported regular caffeine consumption, such as coffee, tea, and energy drinks, had a lesser prevalence of aphthous stomatitis than non-consumers. Furthermore, Armenians in the survey showed that the majority (83.5%) had a low to moderate stress level. Conclusion: The data we collected in our research indicate that the prevalence of Recurrent Aphthous Stomatitis in the Armenian ethnicity was infrequent; over half of the participants didn’t report Recurrent Aphthous Stomatitis in the past 12 months. Which may correlate to their caffeine consumption habits, which can lead to stress reduction.

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Section: Discussionmentioning

confidence: 99%

Association Between Caffeine, Anxiety and the Occurrence of Aphthous Stomatitis in the Armenian Ethnicity

Absoian,

Hameed Alwan

2023

NAMJ

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“…These results obtained in the present study were in accordance with the results of previous wound healing studies performed using Capri extract. [ 10 , 15 , 16 ] To investigate the wound healing activity of C. ovata var. palaestina fruit extract in mice, C. ovata var.…”

Section: Discussionmentioning

confidence: 99%

“…Alwan and Ghani[ 16 ] investigated the histological effects of another extract, C. spinosa , on incisional cutaneous wounds in diabetic rats. Diabetes was induced with a peritoneal injection of a single dose of alloxan (150 mg/kg).…”

Section: Discussionmentioning

confidence: 99%

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The effects of Capparis ovata seed oil on the healing of traumatic skin wounds

Celepli¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Capparis ovata contains alkaloids, lipids, polyphenols, flavonoids, and also is rich in antioxidants. Conventionally, in Turkey, the flower buds, root, bark, and fruits of C. ovata are used for their analgesic, anti-inflammatory, anti-rheumatism, tonic, and diuretic effects. The aim of this study was to examine the effect on wound healing of C. ovata seed oil (COSO), which is known to have antioxidant, anti-inflammatory, and antibacterial properties. METHODS: In the study, 20 Wistar albino female rats were randomly divided into two groups of 10 animals each. A standard full-thickness skin defect was created on the back area of the rats. In both groups, after cleaning the wounds with saline daily, no active substance other than saline was applied to the control group, while 1 cc/day COSO was applied to the wounds of the rats in the study group. On the post-operative 14 th day, the rats were reanesthetized and wound area measurements were made. Then, excision was performed to include 1 cm of intact tissue around the wound, which remained unhealed, and samples were taken for histopathological examination. RESULTS: The changes in wound areas showed that after 14 days, the improvement in the group treated with caper oil (32.78; 95% confidence interval, 17.21–48.36) was significantly higher than that of the control group (65.41; 95% confidence interval, 49.84–80.98) (p=0.009). The histopathological scores showed a significant difference between the groups in respect of epithelial formation, inflammation, and fibrosis development. No epithelial tissue formation was observed in the control group (90%), and more incomplete re-epithelization and focal epidermal hyperplasia were observed in the treatment group (60%). Fibrosis development was mild and weak (70%) in the control group and was evaluated as severe and intense (60%) in the treatment group. Perivascular edema was mild (50%) and vascularity was immature (60% – an indicator of neovascularization) in the treatment group. These histopathological results showed that the treatment group inflammation phase was completed and the proliferation phase started, as well as the effectiveness of the use of caper oil on epithelization, angiogenesis, and fibrosis, which are important histopathological parameters in the evaluation of wound healing compared to the control group. CONCLUSION: From the results of this study, it was concluded that COSO significantly enhances the healing of full-thickness skin wounds and this effect is primarily related to its anti-inflammatory effect.

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Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review

et al. 2023

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Natural-based biomaterials play an important role in developing new products for medical applications, primarily in cutaneous injuries. A large panel of biomaterials with antioxidant properties has revealed an advancement in supporting and expediting tissue regeneration. However, their low bioavailability in preventing cellular oxidative stress through the delivery system limits their therapeutic activity at the injury site. The integration of antioxidant compounds in the implanted biomaterial should be able to maintain their antioxidant activity while facilitating skin tissue recovery. This review summarizes the recent literature that reported the role of natural antioxidant-incorporated biomaterials in promoting skin wound healing and tissue regeneration, which is supported by evidence from in vitro, in vivo, and clinical studies. Antioxidant-based therapies for wound healing have shown promising evidence in numerous animal studies, even though clinical studies remain very limited. We also described the underlying mechanism of reactive oxygen species (ROS) generation and provided a comprehensive review of ROS-scavenging biomaterials found in the literature in the last six years. Furthermore, other potential applications of antioxidant biomaterials in the biomedical and industrial fields are also described.

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Histological Evaluation of Local Application of Flavonoid Extract of Capparis Spinosa on Wound Healing in Alloxan-Induced Diabetic Rats

Cited by 3 publications

References 23 publications

Association Between Caffeine, Anxiety and the Occurrence of Aphthous Stomatitis in the Armenian Ethnicity

Association Between Caffeine, Anxiety and the Occurrence of Aphthous Stomatitis in the Armenian Ethnicity

The effects of Capparis ovata seed oil on the healing of traumatic skin wounds

Antioxidant Biomaterials in Cutaneous Wound Healing and Tissue Regeneration: A Critical Review

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