Histological features and in-vitro proteoglycan synthesis in the rabbit craniomandibular joint disc

Mills, David K.; Daniel, Jon C.; Scapino, Robert P.

doi:10.1016/0003-9969(88)90045-3

Cited by 72 publications

(49 citation statements)

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“…Even with splints, the intermediate zone retained its strong alignment with the AP axis of the disc, which is consistent with previous reports of the collagen alignment of this zone in other species (Mills et al, 1988;Mills et al, 1994b;Strauss et al, 1960;Taguchi et al, 1980;Teng and Xu, 1991). It would be reasonable to assume that this zone sees a large tensile force in the AP direction during physiologic function with or without splints.…”

Section: Discussionsupporting

confidence: 90%

“…Prior studies on the human, bovine, dog, rabbit, monkey, sheep, and rat TMJ disc have shown that the fibers of the intermediate zone are oriented predominantly in the anterior-posterior (AP) direction, while the fibers of the anterior and posterior bands are more multidirectional or "basket-woven" (Berkovitz, 2000;Desai et al, 1996;Gillbe, 1973;Landesberg et al, 1996;Mills et al, 1988;Mills et al, 1994b;Strauss et al, 1960;Taguchi et al, 1980;Teng and Xu, 1991). The arrangement or structural organization of the collagen fibers is thought to correspond to the mechanical function of the disc with fibers paralleling the direction of applied tensile loading (Smith et al, 1981).…”

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confidence: 99%

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Morphologic changes in the TMJ following splint wear

2002

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Intraoral splints are a commonly used dental treatment for a variety of conditions. Because such splints alter the condyle-disc-fossa relationship, they probably change the loading status of the temporomandibular joint (TMJ), including the TMJ disc. Collagen, a major constituent of the disc, acts to resist tensile loading, and it is presumed that the fiber orientations of the individual disc bands reflect their functional loading. Therefore, the purpose of this study was to examine effects of intraoral splint wear on TMJ morphology in general, and collagen orientation of the intra-articular disc in particular. Young adult, female miniature pigs were divided into three groups: open-bite splint, protrusive-bite splint, and unsplinted control. Splints were worn for 2 months, after which the TMJ discs were harvested for histological examination and stereological analysis, and the skulls were cleaned. Although the splints had no effect on skull dimensions, changes were seen in the TMJs. The discs of the protrusively-splinted group showed an increased thickness of the posterior band (P Ͻ 0.015) and minor changes in collagen orientation of the anterior band. The most striking change was the presence of a degenerative osseous defect on the medial side of the mandibular condyle in half of the splinted animals. These results indicate that prolonged splint wear can induce remodeling and even injury of TMJ tissues. Anat Key words: temporomandibular joint disc; porcine; morphology; intraoral splints; collagenIntraoral splints are used in dentistry to treat a variety of conditions, such as occlusal malalignments, temporomandibular joint (TMJ) dysfunctions, and sleep apnea (Bondemark, 1999;Carels and van der Linden, 1987;Gianelly et al., 1970;Grim, 1995;Johal and Battagel, 1999;Kimmel, 1994;Major and Nebbe, 1997;Nitzan, 1994;Wright et al., 1995). All splints change the occlusal relationship of the teeth and, hence, the spatial relationship of the TMJ components, although the precise effect varies with the splint (Ito et al., 1986). Additionally, splint wear must affect disc structure, as indicated by studies showing changes in shape (Ferrari and Herring, 1995) and glycosaminoglycan (GAG) content (Mao et al., 1998;Sindelar et al., 2000). However, detailed morphology has not previously been assessed.The TMJ disc is composed of approximately 80% water (Sindelar et al., 2000); the remaining 20% is mostly collagen. Prior studies on the human, bovine, dog, rabbit, monkey, sheep, and rat TMJ disc have shown that the fibers of the intermediate zone are oriented predominantly in the anterior-posterior (AP) direction, while the fibers of the anterior and posterior bands are more multidirectional or "basket-woven"

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confidence: 90%

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Morphologic changes in the TMJ following splint wear

2002

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“…Fibrocartilage is nearly acellular (2-5% cells by volume), with sparsely dispersed chondrocyte-like and fibroblast-like cells that are responsible for extracellular matrix formation and turnover (Grinnell and Lamke, 1984;Mills et al, 1988). At the molecular level, the temporomandibular joint is characterized by a unique distribution of extracellular matrix molecules (Silbermann et al, 1987;Silbermann and von der Mark, 1990;Ben et al, 1991Ben et al, , 1992Milam et al, 1991b).…”

Section: (A) the Temporomandibular Joint Has Unique Featuresmentioning

confidence: 99%

“…The three major constituents of the fibrocartilage matrix are collagen, large and small proteoglycans, and water. The collagen fibrils are organized in a cross-linked network that has high resistance to stretch and tensile forces along the long axes of the fibers and flexibility in other orientations (Mills et al, 1988;Mow et al, 1992). However, unlike hya-line cartilage, in which the major collagen species is type II collagen synthesized by chondrocytes, the major collagen species of fibrocartilage is type I collagen, primarily formed by fibroblast-like cells (Grinnell and Lamke, 1984;Milam et al, 1991b,c ; Kobayashi, 1992;Gage et al, 1990;Haskin, 1995).…”

Section: (A) the Temporomandibular Joint Has Unique Featuresmentioning

confidence: 99%

“…For example, small-molecular-weight proteoglycans are typically found in areas with high resistance to tensile forces (Scott, 1988(Scott, , 1989a, whereas high-molecular-weight proteoglycans have been shown by immunohistochemical staining (which depends on epitope recognition) to be present throughout the fibrocartilages (Mills et a/., 1988;Nakano and Scott, 1989a;Kobayashi, 1992). However, histological stains, such as alcian blue at pH 1 (which depends on the presence of sulfates), have shown that proteoglycans with highly sulfated glycosaminoglycan side-chains are concentrated primarily in areas undergoing compressive loading (Kopp, 1976, 1978Mills et al, 1988;Kuc et al, 1989;Nakano and Scott, 1989a,b;Shira, 1989). The high density of fixed negative charges on the sulfated glycosaminoglycans significantly alters the biomechanical properties of the fibrocartilage (Kempson et al, 1970;Myers and Mow, 1983;Carney and Muir, 1988;Mow et al, 1992) and changes the hydration properties of the cartilage (Haskin, 1995).…”

Section: (A) the Temporomandibular Joint Has Unique Featuresmentioning

confidence: 99%

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Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint

Haskin

Milam²,

Cameron

1995

Critical Reviews in Oral Biology & Medicine

136

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ABSTRACT:The wide range of disease prevalences reported in epidemiological studies of temporomandibular degenerative joint disease reflects the fact that diagnoses are frequently guided by the presence or absence of non-specific signs and symptoms. Treatment is aimed at alleviating the disease symptoms rather than being guided by an understanding of the underlying disease processes. Much of our current understanding of disease processes in the temporomandibular joint is based on the study of other articular joints. Although it is likely that the molecular basis of pathogenesis is similar to that of other joints, additional study of the temporomandibular joint is required due to its unique structure and function. This review summarizes the unique structural and molecular features of the temporomandibular joint and the epidemiology of degenerative temporomandibular joint disease. As is discussed in this review, recent research has provided a better understanding of the molecular basis of degenerative joint disease processes, including insights into: the regulation of cytokine expression and activation, arachidonic acid metabolism, neural contributions to inflammation, mechanisms of extracellular matrix degradation, modulation of cell adhesion in inflammatory states, and the roles of free radicals and heat shock proteins in degenerative joint disease. Finally, the multiple cellular and molecular mechanisms involved in disease initiation and progression, along with factors that may modify the adaptive capacity of the joint, are presented as the basis for the rational design of new and more effective therapy.

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Diarthroses in the mouse: From different cellular structure to similar joint appearance

Livne

1993

Anat. Rec.

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The structure and function of two major joints, the humeroscapular and the squamoso-mandibular joints in mice, are compared. The specific roles that these two joints fulfill during early postnatal period are reflected in a different cellular organization observed in them. Following maturation, when similar functional needs are stressed upon these two joints, similar homologous structures are detected in both of them. A possible conceptual explanation for these observations and their relatedness to the human equivalent joints are discussed.

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Histological features and in-vitro proteoglycan synthesis in the rabbit craniomandibular joint disc

Cited by 72 publications

References 15 publications

Morphologic changes in the TMJ following splint wear

Morphologic changes in the TMJ following splint wear

Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint

Diarthroses in the mouse: From different cellular structure to similar joint appearance

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