Histological Findings in Coil-packed Experimental Aneurysms 3 Months after Embolization

Böcher-Schwarz, H. G.; Ringel, Kurt; Böhl, Jürgen; Filippi, R.; Kempski, Oliver; Perneczky, Axel

doi:10.1227/00006123-200202000-00027

Cited by 15 publications

(13 citation statements)

References 20 publications

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“…Rabbits seem to have a lesser propensity for healing. There was no endothelialization across the aneurysm orifice and no evidence of organized thrombus, but a thickened wall was associated with chronic 31 or no major inflammatory reaction 8 in bifurcation aneurysms.…”

Section: Pathologic Analyses Of Treated Aneurysmsmentioning

confidence: 92%

“…20 Creation of bifurcation aneurysms in rabbits is more difficult and perhaps less reliable, with a higher incidence of anesthesia-related deaths, procedure-related mortality, and parent vessel occlusions. 8,30,31 The elastase model was limited to rabbits, with advantages of easy in handling and long-term survival with aneurysms followed for Ͼ5 years. 32 With some training, the results seem to be reproducible.…”

Section: General Characteristicsmentioning

confidence: 99%

“…29,42,43 Among the 10 studies performed in bifurcation aneurysms in rabbits, 5 revealed a considerable discrepancy between radiologic and pathologic findings, with angiography overestimating the degree of occlusion in all cases. 8,18,30,31 Microscopic recurrences have been described with the rabbit elastase model, but a correlation with angiographic recurrences is rarely possible. 45,49,50 Nevertheless, characteristics of the healing of experimental aneurysms, mainly gleaned from cross-species comparisons, have been described.…”

Section: Pathologic Analyses Of Treated Aneurysmsmentioning

confidence: 99%

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In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY: Animal models are necessary to develop and test innovations in aneurysm therapy before clinical introduction. This review aims at identifying the most likely candidates for standardizing preclinical testing of aneurysm devices. We systematically searched electronic databases for publications on animal aneurysm models from 1961-2008 to assess the methodologic quality of the studies and collect data on the patency and angiographic and pathologic outcomes of treatments. There has been a steady increase in the annual number of publications with time. Species that were most frequently used were dogs, rabbits, and rodents, followed by swine. Most publications are single-laboratory studies with variables and poorly validated outcome measures, a small number of subjects, and limited standardization of techniques. The most appropriate models to test for recurrences after endovascular occlusion were the surgical bifurcation model in dogs, and the elastase-induced aneurysm model in rabbits. A standardized multicenter study is needed to improve the preclinical evaluation of endovascular devices in aneurysm therapy.

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Section: Pathologic Analyses Of Treated Aneurysmsmentioning

confidence: 92%

Section: General Characteristicsmentioning

confidence: 99%

Section: Pathologic Analyses Of Treated Aneurysmsmentioning

confidence: 99%

See 1 more Smart Citation

In Vivo Experimental Intracranial Aneurysm Models: A Systematic Review

Bouzeghrane

Naggara

Kallmes³

et al. 2009

AJNR Am J Neuroradiol

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“…2 Thus, experimental animal studies are crucial to test new and better endovascular devices, to improve long-term aneurysm occlusion. [3][4][5] The choice of the model is essential for the comparability of experimental findings with human conditions. 6 In a comparison of the currently used animal models in rats, rabbits, canines, and swine, [7][8][9] the rabbit model showed advantageous comparability with the human coagulation system and the best cost-effectiveness.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, in the available literature on this model, only general descriptions of the operative technique can be found, without special emphasis on surgical details or the importance of peri-and postoperative management strategies. 4,21,24,27 In the authors' opinion, the following factors play key roles in facilitating microsurgery and improving the outcome of this experimental aneurysm creation: 1) Careful preparation of a long segment of the left CCA, but without destruction of the superior laryngeal nerves and small vessels.…”

Section: Discussionmentioning

confidence: 99%

Improved Microsurgical Creation of Venous Pouch Arterial Bifurcation Aneurysms in Rabbits

Sherif

Marbacher²,

Erhardt³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:The choice of the experimental aneurysm model is essential for valid embolization-device evaluations. So far, the use of the rabbit venous pouch arterial bifurcation aneurysm model has been limited by demanding microsurgery, low aneurysm patency rates, and high mortality. This study aimed to facilitate microsurgery and to reduce mortality by optimized peri-/ postoperative management.

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