Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma

Vesalainen, S; Lipponen, P; Talja, Martti; Syrjänen, Karí

doi:10.1016/0959-8049(94)e0159-2

Cited by 229 publications

(155 citation statements)

References 25 publications

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“…Tumour glandular and cellular morphology evaluated by light microscopy may be regarded as a measure of the sum of all genetic and epigenetic events in the cell, and tumour differentiation has repeatedly been shown to be a valid predictor for outcome in prostate tumour (Vesalainen et al, 1994). Most cellular effects of a change in the hormonal milieu in the normal prostate occur within days after the change (Kyprianou et al, 1988).…”

Section: Regressive Morphologymentioning

confidence: 99%

Short-term cellular effects induced by castration therapy in relation to clinical outcome in prostate cancer

Stattin

Westin²,

Damber³

et al. 1998

Br J Cancer

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Summary To explore the relationship between short-term effects of castration therapy and clinical response, biopsies obtained before and a week after castration therapy from 15 responding and 13 non-responding patients with prostate cancer were investigated. The biopsies were assessed for regressive morphology, apoptotic index by morphological criteria, nuclear area, and immunoreactivity (IR) for Ki-67, p53, bcl-2, bax and Fas. The index was defined as the percentage of immunoreactive cells in a tumour. Regressive morphology was observed in 14 out of 15 responding tumours after therapy, compared with 4 out of 13 non-responders (P < 0.001). Median tumour epithelial cell nuclear area and Ki-67 index decreased equally in both groups. The median apoptotic index increased from 2.6 to 3.5 after castration among responders (P < 0.05), whereas it remained at 2.8 among non-responders. p53 IR was present in three tumours before castration; after therapy p53 reactivity was seen in three additional tumours belonging to the responding group. Median bcl-2 index increased in responders from 1.5 to 10.0 (P < 0.05), and in non-responders from 0.08 to 2.7 (P < 0.05). Bax IR and Fas IR were present in all tumours before therapy and unchanged after therapy. Thus, regressive morphology and an increase in apoptotic index were related to a favourable clinical response. These data suggest that it might be possible to predict the effect of castration therapy by examining tumour biopsies shortly after treatment.

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Section: Regressive Morphologymentioning

confidence: 99%

Short-term cellular effects induced by castration therapy in relation to clinical outcome in prostate cancer

Stattin

Westin²,

Damber³

et al. 1998

Br J Cancer

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“…Vesalainen et al (1994) reported that, in a cohort in which approximately 30% of patients had metastatic disease, tumours with a dense tumour lymphocyte infiltration were associated with higher survival rates than tumours with absent or decreased infiltrates. In contrast, Irani et al (1999) reported that, in patients undergoing radical prostectomy, an increased inflammatory cell infiltrate within the tumour was associated with an increased risk of tumour recurrence.…”

mentioning

confidence: 99%

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

et al. 2004

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The relationship between tumour stage, T-lymphocyte subset infiltration and survival was examined in patients with prostate cancer (n ¼ 80). On multivariate analysis PSA (HR 2.47, 95% CI 1.27 -4.83, P ¼ 0.008) and CD4 þ T-lymphocyte count (HR 2.29, 95% CI 1.25 -4.22, P ¼ 0.008) had independent significance. Increased CD4 þ T-lymphocyte infiltration within the tumour was stage independent and associated with poor outcome in patients with prostate cancer.

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“…This effect could relate to tumor-induced immunosuppression that allows the cancer to advance [25] or could in some cases simply indicate a weak immune response due to other reasons. Since the levels of tumor-infiltrating lymphocytes can be prognostic for prostate cancer progression [26], it may also be valuable to look at the prognostic value of anti-tumor antibody levels, or the relationship between circulating antibody levels and tumor-infiltrating lymphocyte levels.…”

Section: Discussionmentioning

confidence: 99%

An experimental strategy for quantitative analysis of the humoral immune response to prostate cancer antigens using natural protein microarrays

Forrester

Qiu

Mangold

et al. 2007

Proteomics Clinical Apps

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The identification of human tumor antigens has potential utility in the diagnosis and treatment of cancers. We demonstrate here a complete strategy to profile immunoreactivity and identify tumor antigens from proteins derived from tumor cell lines. Microarrays of proteins produced from 2-D LC fractionation of prostate tumor cell-line lysates were used to profile immunoreactivity in the sera of prostate cancer patients and control subjects. Cancer-associated immunoreactivity to distinct groups of chromatography fractions was present in about 50% of the patients, with greater immunoreactivity present in patients with non-organ-confined cancer than in patients with organ-confined cancer. We grouped the immunoreactive fractions by similarities in elution order and patterns of immunoreactivity to guide and interpret the MS analysis of selected fractions, which was used to identify the proteins that may be responsible for the immunoreactivity. As a complementary method to further characterize and validate the immunoreactivity of the proteins identified by mass spectrometry, we demonstrate the use of focused microarrays of recombinant proteins. Disease-associated immunoreactivity was confirmed for one of the identified proteins, human Kallikrein 11. These results demonstrate a practical approach to screening, identifying, and validating immunoreactive proteins that could be applied to diverse studies on humoral immune responses.

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Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma

Cited by 229 publications

References 25 publications

Short-term cellular effects induced by castration therapy in relation to clinical outcome in prostate cancer

Short-term cellular effects induced by castration therapy in relation to clinical outcome in prostate cancer

The relationship between T-lymphocyte subset infiltration and survival in patients with prostate cancer

An experimental strategy for quantitative analysis of the humoral immune response to prostate cancer antigens using natural protein microarrays

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