Histological hanges in the placenta and vascularization of its villi in early- and late-onset preeclampsia

Щеголев, А. И.; Lyapin, V.M.; Туманова, У.Н.; Vodneva, Daria N.; Shmakov, R.G.

doi:10.17116/patol201678113-18

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…An abnormal immune reaction has been proposed as the cause of extensive perivillous fibrin depositions and chronic intervillositis [23,77]. The predominance of angiogenesis with branching vessels in the placenta of COVID-19-affected women revealed by us can be considered as a compensatory process to increase the area of gas exchange of the villous tree in response to uteroplacental hypoxia caused by maternal SARS-CoV-2 infection, as has been demonstrated in preeclampsia [78]. The key role in the formation of fetoplacental angiogenesis throughout gestation is assigned to the vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 и VEGFR-2), placental growth factor (PlGF), angiopoietins, and many other growth factors, which are upregulated with low oxygen tension to facilitate the expansion of placental vascular network [79].…”

Section: Discussionmentioning

confidence: 72%

The Impact of Maternal SARS-CoV-2 Infection Next to Pre-Immunization with Gam-COVID-Vac (Sputnik V) Vaccine on the 1-Day-Neonate’s Blood Plasma Small Non-Coding RNA Profile: A Pilot Study

Timofeeva

Fedorov

Chagovets

et al. 2022

COVID

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The antenatal and postnatal effects of maternal SARS-CoV-2 on the fetus outcomes, especially in the case of maternal pre-vaccination against this infection, are still under investigation. Such effects may be due to placental insufficiency caused by maternal hypoxia and inflammatory response associated with SARS-CoV-2, and/or be a direct cytopathic effect of the virus. In this work, we studied the profile of small non-coding RNAs (sncRNAs) in the blood plasma of a newborn from a mother who had SARS-CoV-2 at the 22nd week of gestation after immunization with Gam-COVID-Vac (Sputnik V). The fetus had ultrasound signs of hypertrophy of the right heart and hydropericardium 4 weeks after infection of the mother with SARS-CoV-2, as well as cysts of the cerebral vascular plexuses by the time of birth. Taking this into account, we compared the sncRNA profile of this newborn on the first postpartum day with that of neonates born to COVID-19-negative women with different perinatal outcomes: severe cardiovascular and/or neurological disorders, or absence of any perinatal complications. According to next-generation sequencing data, we found that the fetus born to a COVID-19-affected mother pre-immunized with Gam-COVID-Vac (Sputnik V) vaccine differs from newborns with severe cardiovascular and/or nervous system abnormalities either in multidirectional changes in circulating sncRNAs or in less pronounced unidirectional changes in the level of sncRNAs relative to control samples. Considering this, it can be concluded that maternal vaccination against SARS-CoV-2 before pregnancy has a protective effect in preventing antenatal development of pathological processes in the cardiovascular and nervous systems of the neonate associated with COVID-19.

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Section: Discussionmentioning

confidence: 72%

The Impact of Maternal SARS-CoV-2 Infection Next to Pre-Immunization with Gam-COVID-Vac (Sputnik V) Vaccine on the 1-Day-Neonate’s Blood Plasma Small Non-Coding RNA Profile: A Pilot Study

Timofeeva

Fedorov

Chagovets

et al. 2022

COVID

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“…In preeclampsia, the number of syncytial knots was also increased in observed [7]. At the same time, increased numbers of syncytial knots were significantly more often observed in late-onset preeclampsia compared to early-onset preeclampsia [1].…”

Section: Resultsmentioning

confidence: 83%

The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity

et al. 2021

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A comparative morphological study was carried out to analyze the number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 categorized by the disease severity. The number of syncytial knots was assessed on specimens stained with hematoxylin and eosin. VEGF expression was determined by immunohistochemical analysis in syncytiotrophoblast and villous endothelial cells. Morphological study of the placenta tissue of parturient women with COVID-19 showed increased numbers of syncytial knots in the villi, indicating the development of preplacental hypoxia. High VEGF expression in syncytiotrophoblast and vascular endotheliocytes reflects a stereotyped response to hypoxia and can underlie the development of a preeclampsia-like syndrome. The number of syncytial knots and VEGF expression in placental villi in parturient women with COVID-19 depended on the disease severity.

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“…On the other hand, other investigators reported decreased microvessel counts in PE placentas [7,9,11,31,32] . These studies included population of early onset PE and reported poor fetal outcome with FGR and still birth.…”

Section: Similar To Our Results Sankar Et Al (2012) Andmentioning

confidence: 88%

Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?

Wageh

Nagib

Eid

2019

Evidence Based Women's Health Journal

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Background: Preeclampsia (PE) is one of the most common pregnancy complications affecting approximately 5-7% of pregnant women worldwide. Pathogenesis of PE is still mysterious. Literature studies reported differences between early and late onset PE. Also, whether placenta of late-onset PE without fetal growth restriction (FGR) is different from normal one needs further declaration. Objective: This study aims at evaluating the placental microvessel density (MVD), apoptosis and endoglin (CD105) expression in late-onset PE without FGR. Patients and Methods: Placentae of 15 PE and 15 matched control ones were evaluated grossly, microscopically and by immunohistochemistry for caspase-3, CD 34 and CD105. Results: Placentas in PE group showed a statistically significant difference as regard size, syncytial knots, perivillous fibrin deposition, villous infarction increased apoptosis, and endoglin (CD105) expression. However, the percentage of terminal villi and microvessel density (MVD) were comparable in both groups. Conclusion: Placenta from late onset PE without FGR is still different from the normal placenta whatever time onset of PE pathogenesis may be similar. Absence of changes in MVD may explain good fetal outcome.

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Histological hanges in the placenta and vascularization of its villi in early- and late-onset preeclampsia

Cited by 15 publications

References 21 publications

The Impact of Maternal SARS-CoV-2 Infection Next to Pre-Immunization with Gam-COVID-Vac (Sputnik V) Vaccine on the 1-Day-Neonate’s Blood Plasma Small Non-Coding RNA Profile: A Pilot Study

The Impact of Maternal SARS-CoV-2 Infection Next to Pre-Immunization with Gam-COVID-Vac (Sputnik V) Vaccine on the 1-Day-Neonate’s Blood Plasma Small Non-Coding RNA Profile: A Pilot Study

The Number of Syncytial Knots and VEGF Expression in Placental Villi in Parturient Woman with COVID-19 Depends on the Disease Severity

Placenta Of Late Onset Preeclampsia Without Fetal Growth Restriction : Is It Different From The Normal?

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