Histological, histochemical, and fine structural observations on the lymph node of the common seal (Phoca vitulina) and the grey seal (Halichoerus grypus)

Welsch, Ulrich; Schwertfirm, Sabine; Skírnisson, Karl; Schumacher, Udo

doi:10.1002/(sici)1097-0185(199702)247:2<225::aid-ar9>3.0.co;2-w

Cited by 11 publications

(11 citation statements)

References 28 publications

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“…The histology of the lymph node of the leopard seal was similar to previous reports of the lymph node in pinnipeds (Lowenstine & Osborn, 1990; Welsch et al. 1997) and terrestrial mammals.…”

Section: Discussionsupporting

confidence: 87%

“…Plasma cells were common in the medulla of the lymph nodes of the leopard seals examined, similar to findings for harbour and grey seals (Welsch et al. 1997).…”

Section: Discussionsupporting

confidence: 83%

“…The activity state and appearance of the lymph nodes examined was variable and the key factors thought to be contributing to this variation include history of antigen exposure, the particular lymph node examined, the age of the seal from which the lymph node was taken, as well as cause of death. In lymph nodes with cortical follicles, the majority were secondary follicles similar in appearance to the follicles in harbour and grey seals, Halichoerus grypus (Welsch et al. 1997).…”

Section: Discussionmentioning

confidence: 78%

“…comm.). As a consequence, in some of the lymph nodes examined in the leopard seal, the cortico‐medullary junction was difficult to delineate clearly, a finding not reported in harbour and grey seals (Welsch et al. 1997).…”

Section: Discussionmentioning

confidence: 97%

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Histology of selected tissues of the leopard seal and implications for functional adaptations to an aquatic lifestyle

Gray

Canfield

Rogers³

2006

Journal of Anatomy

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The microscopic anatomy of the cardio-respiratory system, digestive system, kidney, lymphatic system and integument was investigated in the leopard seal, Hydrurga leptonyx , by examining histological sections of tissues collected from leopard seals in Antarctica and New South Wales, Australia. The majority of the tissues had similar histological features to those described in terrestrial mammals and other pinniped species, particularly phocid seals. Differences noted included readily identifiable Purkinje cells within the endocardium, muscular rather than cartilaginous reinforcement of the smaller airways, a single capillary layer within the alveolar septa, limited and variable keratinization of the oesophageal epithelium, few lymphoid follicles within the lamina propria of the gastrointestinal tract, and an absence of a sporta perimedullaris musculosa described in the kidney of cetaceans and some pinniped species. Adaptations of the lung, spleen and integument, similar to those described in other pinnipeds, including reinforcement of the pulmonary terminal airways, prominent pulmonary interlobular septa, ample smooth muscle in the capsule and trabeculae of the spleen, increased thickness of the epidermis, welldeveloped dermal sebaceous glands, and a thick blubber layer, appear to confer upon the leopard seal advantages related to its aquatic lifestyle.

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“…The histology of the lymph node of the leopard seal was similar to previous reports of the lymph node in pinnipeds (Lowenstine & Osborn, 1990; Welsch et al. 1997) and terrestrial mammals.…”

Section: Discussionsupporting

confidence: 87%

“…Plasma cells were common in the medulla of the lymph nodes of the leopard seals examined, similar to findings for harbour and grey seals (Welsch et al. 1997).…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 97%

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Histology of selected tissues of the leopard seal and implications for functional adaptations to an aquatic lifestyle

Gray

Canfield

Rogers³

2006

Journal of Anatomy

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“…The molecular characterization of the morphological subforms of lining and intraluminal cells of the lymph node sinus now obviously provides sufficient data and markers to identify these cells, to subsume them under a collective term as "sinus endothelial/virgultar cells" (SEVCs), and to lay to rest the various hypotheses of a non-endothelial (e.g., monocytic, FRC) nature and origin of these cells (for controversial hypotheses and arguments, see Wacker 1994;Wacker et al 1997;Gretz et al 1997;Welsch et al 1997;Crivellato and Mallardi 1998;Kaldjian et al 2001;WillardMack 2006; and references cited therein; for a "historic" discussion, see also Raviola 1975). Clearly, the presence of an impressive ensemble of true endothelial differentiation markers establishes their endothelial or endothelium-derived nature and origin.…”

Section: Discussionmentioning

confidence: 99%

Endothelial and virgultar cell formations in the mammalian lymph node sinus: endothelial differentiation morphotypes characterized by a special kind of junction (complexus adhaerens)

et al. 2008

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The lymph node sinus are channel structures of unquestionable importance in immunology and pathology, specifically in the filtering of the lymph, the transport and processing of antigens, the adhesion and migration of immune cells, and the spread of metastatic cancer cells. Our knowledge of the cell and molecular biology of the sinus-forming cells is still limited, and the origin and biological nature of these cells have long been a matter of debate. Here, we review the relevant literature and present our own experimental results, in particular concerning molecular markers of intercellular junctions and cell differentiation. We show that both the monolayer cells lining the sinus walls and the intraluminal virgultar cell meshwork are indeed different morphotypes of the same basic endothelial cell character, as demonstrated by the presence of a distinct spectrum of general and lymphatic endothelial markers, and we therefore refer to these cells as sinus endothelial/virgultar cells (SEVCs). These cells are connected by unique adhering junctions, termed complexus adhaerentes, characterized by the transmembrane glycoprotein VE-cadherin, combined with the desmosomal plaque protein desmoplakin, several adherens junction plaque proteins including α-and β-catenin and p120 catenin, and components of the tight junction ensemble, specifically claudin-5 and JAM-A, and the plaque protein ZO-1. We show that complexus adhaerentes are involved in the tight three-dimensional integration of the virgultar network of

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Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants

Kirkegaard

Sonne

Leifsson

et al. 2005

Science of The Total Environment

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Histological, histochemical, and fine structural observations on the lymph node of the common seal (Phoca vitulina) and the grey seal (Halichoerus grypus)

Cited by 11 publications

References 28 publications

Histology of selected tissues of the leopard seal and implications for functional adaptations to an aquatic lifestyle

Histology of selected tissues of the leopard seal and implications for functional adaptations to an aquatic lifestyle

Endothelial and virgultar cell formations in the mammalian lymph node sinus: endothelial differentiation morphotypes characterized by a special kind of junction (complexus adhaerens)

Histology of selected immunological organs in polar bear (Ursus maritimus) from East Greenland in relation to concentrations of organohalogen contaminants

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