Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status

Jaeger, Teresa; Ring, Johannes; Andrés, Christian

doi:10.1155/2012/983421

Cited by 65 publications

(59 citation statements)

References 42 publications

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“…Immunohistochemical analyses may be performed to differentiate between gastric and colonic primary tumors, with CK7 and CK20 commonly used as tumor markers (16). CK7 expression has been observed in the majority of types of carcinoma, in carcinoid tumors originating from lungs and gastrointestinal tract (17), and in Merkel cell tumors of the skin (18). CK20 + staining is observed in the vast majority of cases of colorectal carcinoma (17) and Merkel cell tumors (19), in addition to a high proportion of cases of gastric carcinoma, cholangiocarcinoma, pancreatic carcinoma and transitional cell carcinoma (16).…”

Section: Discussionmentioning

confidence: 99%

Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report

et al. 2015

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Abstract. Gastric cancer is one of the most common malignancies in Asia, and the second most common cause of cancer-associated mortality in Japan. Colorectal metastases originating from gastric adenocarcinoma are extremely rare. The present study reports an unusual case of lymphogenous sigmoid metastasis of gastric adenocarcinoma occurring in a 58-year-old female patient. Endoscopic and radiological findings were indicative of 0-IIc+IIa early gastric cancer, and radical distal gastrectomy with D2 lymph node dissection was performed. The pathological diagnosis was stage IA gastric adenocarcinoma (T1bN0M0), according to the Japanese classification of gastric cancer. A follow-up examination at 18 months post surgery revealed a recurrence of paraaortic lymph node metastasis, detected by abdominal computed tomography (CT) and positron emission tomography (PET)/CT. The patient received chemotherapy with S-1 and cisplatin. Subsequently, radiotherapy was administered to the paraaortic lymph nodes at levels Th11-L3. Follow-up abdominal CT and PET/CT revealed an enlarged left ovary, and abnormal uptake in the left ovary and sigmoid colon. An oophorectomy and sigmoidectomy with D3 lymph node dissection were performed. The pathological diagnosis was metastatic adenocarcinoma; this was identical to the gastric pathology in the previous pathological report. The patient continued treatment with chemotherapy. Although sigmoid colonic metastasis from gastric cancer is extremely rare, metastasis from gastric cancer must be considered during the differential diagnosis of cases involving a colorectal mass and a previous history of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report

et al. 2015

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“…MCC is usually described in dermatology textbooks and review articles as a raised red/pink or blue/violaceous nodular lesion that can develop in any part of the integument without specific clinical features [7,8,9,10,11]. The unique distinctive characteristic that several authors emphasize is that it tends to be a fast-growing asymptomatic tumor (63% of patients in a survey reported rapid growth of their tumors within 3 months) [9].…”

Section: Discussionmentioning

confidence: 99%

Merkel Cell Carcinoma: Differences between Sun-Exposed and Non-Sun-Exposed Variants - A Clinical Analysis of 36 Cases

Marcoval

Ferreres²,

Penín³

et al. 2014

Dermatology

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Background: There are few studies focusing on the clinical characteristics of Merkel cell carcinoma (MCC). Objective: To retrospectively analyze the clinical features of our patients and their relationship with sun exposure. Methods: Thirty-six patients diagnosed with MCC (20 men and 16 women, mean age 72.08 years) were included in the study. Results: 21 patients developed MCC in sun-exposed skin and 15 patients in non-sun-exposed areas. MCC was >2 cm in 19 cases. Six of the 7 patients who died as a result of MCC had non-sun-exposed tumors. Only tumor size >2 cm significantly influenced survival (p = 0.033). Conclusion: Sun-exposed lesions tended to be <2 cm in diameter and were more common in men, while non-sun-exposed tumors were larger, usually occurring in women and carrying a greater likelihood of death by MCC. Non-sun-exposed tumors usually present as fast-growing, multilobar nodular lesions with a smooth shiny surface.

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“…One of those markers is CK-7(Cytokeratin-7) may be positive in carcinoid and basal cell carcinoma but negative in MCC. S-100 protein is another marker used to differentiate between malignant melanoma (usually positive) and MCC (usually negative) [36]. Synaptophysin is a trans-membrane channel protein of small pre-synaptic vesicles.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Merkel cell carcinoma: literature review

Al‐Zawi

Prodromou²,

Chicken³

et al. 2017

Nowotwory. Journal of Oncology

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Histological, Immunohistological, and Clinical Features of Merkel Cell Carcinoma in Correlation to Merkel Cell Polyomavirus Status

Cited by 65 publications

References 42 publications

Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report

Sigmoid colonic metastasis by lymphatic spread occurring with unilateral Krukenberg tumor considered to be caused by stage IA early gastric cancer: A case report

Merkel Cell Carcinoma: Differences between Sun-Exposed and Non-Sun-Exposed Variants - A Clinical Analysis of 36 Cases

Merkel cell carcinoma: literature review

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