Histological, laboratory, and x‐ray findings after repair of the common bile duct with a Teflon^® graft

Abstract

The common duct was ligated in 25 dogs, 5 of which served as controls. Serum bilirubin, GOT, GPT, and alkaline phosphatase were measured pre-and postoperatively. Eight days later, in 10 dogs, a longitudinal incision was made across the stenosed segment of the common bile duct, which was then widened with a Teflon | patch. In 10 other dogs, the stenosis was resected and the defect was bridged with a Teflon | prosthesis. A few days later, laboratory parameters returned to normal. Histological examination after 4 weeks showed that the Teflon | patch and Teflon | prosthesis were lined with bile duct epithelium. X-ray studies 6, 12 and 24 months after repair showed no evidence of stenosis.We conclude that it is possible to use a Teflon | graft in reconstructive common bile duct surgery.

A novel therapy strategy for bile duct repair using tissue engineering technique: PCL/PLGA bilayered scaffold with hMSCs

“…The popularization of laparoscopic cholecystectomy may explain the increase in the numbers of these reported injuries (Zografakis et al ., ). Although the routine treatment, such as stent placement, PTBD and bilioenteric anastomosis, is very effective at relieving CBD obstructions and repair of injured bile duct, there is a high risk of complications, for example, occlusion, infections, formation of scar tissue and stenosis, and reoperation risks are very common and troublesome (Hartung et al ., ; Wills et al ., , Han et al ., , Mauri et al ., ). Treatment that successful replicates the function of the stent placement and is conducive to repair of the injured biliary tract would therefore be of great significance in reducing the discomfort and morbidity of patients.…”

Fascioperitoneal graft with T-tube drainage for patching bile duct defects

“…Note the epithelialization from the biliary epithelium to the graft side (H.E 10×2.5; 20×2. 5) for the reconstruction of bile duct defects were reported and the completion of biliary epithelization in 4-5 weeks was shown in these studies [22,23,24].…”

Common bile duct repair with titanium staples Comparison with suture closure

“…Although there was no calculus formation adjacent to the bare clip or elsewhere in the duct, the long-term effects and fate of the exposed clip remain unknown. However, the ability of the biliary epithelium to regenerate over various types of biological and synthetic materials including metal has been demonstrated [1,8].…”