Histological, microbiological and haematological investigations in denture-induced stomatitis

Jennings, K.J.; MacDonald, D.G.

doi:10.1016/0300-5712(90)90093-t

Cited by 17 publications

(18 citation statements)

References 11 publications

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“…Several subsequent studies have confirmed that if Candida does begin to invade the superficial layers of the oral mucosa, a hyperplastic response of the epithelium ensues (Sohnle and Kirkpatrick, 1978;Odds, 1988). This has been further confirmed by Jennings and MacDonald (1990), who observed a 66% increase in the average epithelial thickness in 10 patients with chronic atrophic candidosis when compared with a normal population. Partridge et al (1971) contend that such a hyperplastic response, resulting in the formation of a plaque, is directly related to the virulence of the Candida isolates.…”

Section: Hyperplastic Candidosissupporting

confidence: 62%

Chronic Hyperplastic Candidosis/Candidiasis (Candidal Leukoplakia)

Sitheeque

Samaranayake

2003

Critical Reviews in Oral Biology & Medicine

217

173

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Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process. In the final part of the review, newer molecular biological aspects of the disease are considered together with the management protocols that are currently available, and directions for future research.

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Section: Hyperplastic Candidosissupporting

confidence: 62%

Chronic Hyperplastic Candidosis/Candidiasis (Candidal Leukoplakia)

Sitheeque

Samaranayake

2003

Critical Reviews in Oral Biology & Medicine

217

173

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“…Therefore, the model does not simulate a clinically relevant form of DS. Moreover, DS is not associated with immune deficiency or invasive infection (28,46). On the other hand, this model is potentially quite useful for quickly evaluating the ability of different C. albicans strains to form biofilms on denture material in an in vivo setting, with the caveat that the ability of the immune system to interfere with biofilm formation could not be evaluated.…”

Section: Figmentioning

confidence: 99%

Development of a Contemporary Animal Model of Candida albicans-Associated Denture Stomatitis Using a Novel Intraoral Denture System

et al. 2012

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bDenture stomatitis (DS) is a fungal infection characterized by inflammation of the oral mucosa in direct contact with the denture and affects up to 50% of denture wearers. Despite the prevalence, very little is known about the role of fungal or host factors that contribute to pathogenesis. Recently, we developed a novel intraoral denture system for rodent research. This denture system consists of custom-fitted fixed and removable parts to allow repeated sampling and longitudinal studies. The purpose of this study was to use this denture system to develop a clinically relevant animal model of DS. To establish DS, rats were inoculated with pelleted Candida albicans, which resulted in sustained colonization of the denture and palate for 8 weeks postinoculation. Biofilm formation on the denture was observed by week 4 and on the palate by week 6 postinoculation. Rats were monitored for clinical signs of disease by assigning a clinical score after macroscopic examination of the palate tissue according to Newton's method. By week 4 postinoculation, the majority of inoculated rats with dentures exhibited a clinical score of 1 (pinpoint erythema). By week 6 and week 8 postinoculation, increasing percentages of rats exhibited a clinical score of 2 (diffuse erythema/ edema). Histological analysis of palate tissue demonstrated progressively increasing inflammatory cell recruitment throughout the time course of the infection. Palatal biofilm formation was commensurate with development of palatal erythema, which suggests a role for biofilm in the inflammatory response.

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“…The ability of Candida albicans to induce epithelial hyperplasia was subsequently shown by Cawson 24 . This was supported by several studies, showing that in addition to inducing hyperplasia, Candida albicans could also induce epithelial atypia and dysplasia, possibly leading to malignancy 5,25–29 …”

Section: Discussionmentioning

confidence: 81%