Histological patterns of head and neck tumors: An insight to tumor histology

Dive, Alka; Bodhade, Ashish; M, Mishra; Upadhyaya, Neha

doi:10.4103/0973-029x.131912

Cited by 16 publications

(10 citation statements)

References 26 publications

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“…7D for a quantitation). These whorls are found in HPV lesions ( 94 ), and HPV-positive ano-genital cancers and head and neck cancers ( 95 , 96 ). In addition to the increased number of whorls in the S23A cells, we also observed several patches where the epithelial layer invades into the stromal collagen plug ( Fig.…”

Section: Resultsmentioning

confidence: 99%

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Prabhakar

James

Das

et al. 2021

mBio

117

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Section: Resultsmentioning

confidence: 99%

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Prabhakar

James

Das

et al. 2021

mBio

117

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“…As head and neck lesions, most of these lesions happened in the nose followed by oral cavity and scalp, constituting 29.7%, 23.4%, and 14.1%, respectively. Oral and maxillofacial sites are the most frequent sites for head and neck lesions, as widely reported [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features of Patients Nominated for Head and Neck Biopsies: A One-Year Series

Alshammari

Alharbi

Bealy

et al. 2021

Cureus

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Background Head and neck lesions, which are predominantly benign, were widely reported. Some of these tumors are potentially neoplastic and others are non-neoplastic. Therefore, this study aimed to assess the clinicopathological features of patients nominated for head and neck biopsies. Methodology In this study, data regarding head and neck biopsies were retrieved from the Department of Pathology at King Khalid Hospital, Hai'l, Northern Saudi Arabia. Data referring to head and neck biopsies of patients who were diagnosed during the period from January 2018 to December 2018 were included. Results The initial clinical presentations were stated for 50/64 (78.1%) head and neck lesions, 12/64 (18.8%) head and neck cysts, 1/64 (1.6%) keloid, and 1/64 (1.6%) ischemia. With regard to the biopsy's site, most were taken from the nose followed by oral cavity, scalp, ear, face, and eye, constituting 19/64 (29.7%), 15/64 (23.4%), 9/64 (14.1%), 5/65 (7.8%), 4/64 (6.2%), and 3/64 (4.7%), respectively. Conclusion Head and neck benign lesions, predominantly inflammatory lesions, are common in Northern Saudi Arabia. Accurate identification of these lesions is important during histopathological diagnosis, as some have pathological features that mimic some potentially neoplastic lesions.

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“…The great majority of HNC originate from the squamous cells lining the mucosal epithelium in head and neck sites, being collectively named head and neck squamous cell carcinomas (HNSCC). The head and neck anatomical sites more frequently affected by the development of HNSCC are the oral cavity, pharynx, and larynx [ 3 , 4 ]. Together, these three anatomical sites congregate the vast majority of HNSCC cases and the major number of deaths, as previously estimated [ 1 , 5 ] and summarized in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas

Costa

Mendes

Pontes

et al. 2021

Cancers

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Head and neck squamous cell carcinomas (HNSCC) are among the most common and lethal tumors worldwide, occurring mostly in oral cavity, pharynx, and larynx tissues. The squamous epithelia homeostasis is supported by the extracellular matrix (ECM), and alterations in this compartment are crucial for cancer development and progression. Laminin is a fundamental component of ECM, where it represents one of the main components of basement membrane (BM), and data supporting its contribution to HNSCC genesis and progression has been vastly explored in oral cavity squamous cell carcinoma. Laminin subtypes 111 (LN-111) and 332 (LN-332) are the main isoforms associated with malignant transformation, contributing to proliferation, adhesion, migration, invasion, and metastasis, due to its involvement in the regulation of several pathways associated with HNSCC carcinogenesis, including the activation of the EGFR/MAPK signaling pathway. Therefore, it draws attention to the possibility that laminin may represent a convergence point in HNSCC natural history, and an attractive potential therapeutic target for these tumors.

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Histological patterns of head and neck tumors: An insight to tumor histology

Cited by 16 publications

References 26 publications

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle

Clinicopathological Features of Patients Nominated for Head and Neck Biopsies: A One-Year Series

Potential Therapeutic Significance of Laminin in Head and Neck Squamous Carcinomas

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