Histological studies of facial acne and atrophic acne scars treated with a bipolar fractional radiofrequency system

Kaminaka, Chikako; Uede, Mikiko; Nakamura, Yasushi; Furukawa, Fukumi; Yamamoto, Yuki

doi:10.1111/1346-8138.12483

Cited by 16 publications

(12 citation statements)

References 10 publications

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“…discovered increases in the levels of procollagen types I and III, as well as elastin. In addition, in our previous study of atrophic acne scars we observed the thermal denaturation of peri‐hair follicle collagen, hair follicles and sebaceous glands . These results indicate that bipolar FRF treatment can lead to collagen fiber remodeling in the deep dermis and also affects adnexal structures.…”

Section: Discussionsupporting

confidence: 51%

“…In addition, in our previous study of atrophic acne scars we observed the thermal denaturation of peri-hair follicle collagen, hair follicles and sebaceous glands. 21 These results indicate that bipolar FRF treatment can lead to collagen fiber remodeling in the deep dermis and also affects adnexal structures. Acne vulgaris is a disorder that involves increased sebum production, keratinocyte proliferation within the follicular epithelium and follicular colonization by Propionibacterium acnes, and these symptoms are the main targets of treatment.…”

Section: Discussionmentioning

confidence: 76%

“…1 Previously, the histological changes produced by the same bipolar FRF devices have been examined in biopsy examinations of acne scar skin tissue. 15,20,21 Omi et al reported remodeling of the dermis to replace acne scar-associated morphological and ultrastructural irregularities with a more normal architecture, particularly in the case of elastic fibers and over-deposition of elastin. 20 Kim et al 15 discovered increases in the levels of procollagen types I and III, as well as elastin.…”

Section: Discussionmentioning

confidence: 99%

“…The involvement of the reticular dermis can result in “ice pick” scars, “boxcar” scars and “rolling” scars . Previously, the histological changes produced by the same bipolar FRF devices have been examined in biopsy examinations of acne scar skin tissue . Omi et al .…”

Section: Discussionmentioning

confidence: 99%

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Clinical studies of the treatment of facial atrophic acne scars and acne with a bipolar fractional radiofrequency system

Kaminaka

Uede

Matsunaka

et al. 2015

The Journal of Dermatology

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Few clinical studies have examined the utility of bipolar fractional radiofrequency (FRF) therapy as a treatment for atrophic acne scars and active acne in people with darker skin. This study was designed to compare the safety and efficacy of bipolar FRF therapy as a treatment for atrophic acne scars and acne vulgaris. Twenty-three Japanese patients with atrophic acne scars and mild to severe acne on both cheeks were treated with a bipolar FRF system (eMatrix; Syneron, Yokneam Illit, Israel). Five treatment sessions were carried out at 1-month intervals, and the patients were followed up for 3 months after the final treatment. Assessments of scar severity and the number of acne lesions and 3-D in vivo imaging analysis were performed. Evaluations of the treatment outcomes and their effects on the patients' quality of life (QOL) were also carried out. We demonstrated that the improvement in scar volume was marked in the patients with mild scars and was at least moderate in 23 (57.5%) of the treated areas. With regard to the number of acne lesions, the treated areas exhibited significantly fewer lesions compared with the baseline at each time point (P < 0.05). The patients' assessments of the treatment outcomes and their QOL indicated that both had improved significantly by the end of the study. Furthermore, significant reductions in the patients' sebum levels, skin roughness and scar depth were observed. Bipolar FRF treatment significantly improved the atrophic acne scars and acne of Japanese patients and had minimal side-effects.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical studies of the treatment of facial atrophic acne scars and acne with a bipolar fractional radiofrequency system

Kaminaka

Uede

Matsunaka

et al. 2015

The Journal of Dermatology

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“…A similar effect was found in our study; as the number of treatments increased, both radiofrequency instruments were able to improve active acne. Several studies have explored the mechanism of radiofrequency treatment for the treatment of active acne, which may include heat generated by radiofrequency inducing thermal denaturation of the peri‐hair follicle collagen, hair follicle, and sebaceous gland and killing of C acnes , the pathogenic factor in the development of acne vulgaris.…”

Section: Discussionmentioning

confidence: 99%

A split‐face comparison of a fractional microneedle radiofrequency device and fractional radiofrequency therapy for moderate‐to‐severe acne vulgaris

Zeng

Liu

Zhao

et al. 2020

J of Cosmetic Dermatology

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Purpose Radiofrequency equipment, including invasive fractional microneedle radiofrequency (FMR) and noninvasive fractional radiofrequency (FR), has facilitated progress in the field of active acne treatment, but clinical data are limited. This study aimed to compare the efficacy and safety of FMR and FR in the treatment of moderate‐to‐severe acne vulgaris. Methods Ten patients with moderate‐to‐severe acne were enrolled in a 24‐week, prospective, single‐blind, randomized, comparative clinical trial with a split‐face design. Fractional microneedle radiofrequency treatment was provided on one side of the face and FR on the opposite side. Three consecutive treatments were performed at 4‐week interval. Objective assessment of efficacy was performed using the Acne Severity Index (ASI), and acne inflammatory lesions and noninflammatory lesions were evaluated. Results After the first treatment, ASI and both inflammatory and noninflammatory lesions of the FMR‐treated side were improved to a greater degree than the FR‐treated side. Patients' subjective satisfaction was also better regarding the FMR‐treated side. After subsequent treatments, efficacy improves for both groups, and no significant differences in the above efficacy parameters between the two groups were observed. Pain scores were significantly higher for the FR‐treated side than the FMR‐treated side. Conclusion Fractional microneedle radiofrequency is faster and more effective than FR for the treatment of moderate and severe acne after only one treatment. However, after several treatment sessions, both FMR and FR proved to be safe and effective for long‐term treatment of moderate‐to‐severe acne. Therefore, invasive radiofrequency, such as FMR, or noninvasive radiofrequency, such as FR, can successfully treat active acne.

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High versus moderate energy use of bipolar fractional radiofrequency in the treatment of acne scars: a split-face double-blinded randomized control trial pilot study

et al. 2015

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Bipolar fractional radiofrequency (FRF) device was firstly FDA-approved for treating atrophic acne scar in 2008 through the process of dermal coagulation and minimal epidermal ablation. The average energy at 60 mJ/pin was widely used to treat atrophic acne scars. However, the higher energy was delivered, the deeper ablation and coagulation were found. At present, the new generation of a device with bipolar FRF technology with electrode-pin tip was developed to maximize ability to deliver energy up to 100 mJ/pin. The objective of the study was to explore and compare the efficacy of utilizing high energy (100 mJ/pin) and moderate energy (60 mJ/pin) of bipolar fractional radiofrequency in treatment of atrophic acne scar in Asians. This is a split-face, double-blinded, randomized control trial, pilot study by using parallel group design technique. Thirty healthy subjects with Fitzpatrick skin phototype III-IV diagnosed as atrophic acne scares were enrolled. All subjects received four monthly sessions of bipolar FRF treatment. Left and right facial sides of individual patients were randomly assigned for different energy (high energy at 100 mJ/pin versus moderate energy at 60 mJ/pin). Acne scars improvement was blinded graded by dermatologist using global acne scarring score (GASS) which was subjectively evaluated at baseline, 1-, 3-, and 6-month follow-up. Objective scar analysis was also done using UVA-light video camera to measure scar volume, skin smoothness, and wrinkle at baseline, 3-, and 6-month follow-up after the last treatment. Side effects including pain, erythema, swelling, and crusting were also recorded. Thirty subjects completed the study with full 4-treatment course. The mean GASS of high energy side and moderate energy side was significantly reduced at 1-, 3-, and 6-month follow-up visits. At 1 month follow-visit, high energy side demonstrated significant improvement compared with moderate energy side (p = 0.03). Postinflammatory hyperpigmentation (PIH) developed in 21/120 sessions in high energy side (17.5 %) and 16/120 sessions in moderate energy side (13.3 %). Pain score and the duration of erythema after treatments were significant higher on the side that was treated with high energy. Bipolar FRF device was safe and effective in the treatment of atrophic acne scars in Asians. High energy setting demonstrated significant higher efficacy at 1 month follow-visit. However, the efficacy of both energy settings was comparable at 3- and 6-month follow-up. In addition, side effects were significantly more intense on the side treated with high energy.

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Histological studies of facial acne and atrophic acne scars treated with a bipolar fractional radiofrequency system

Cited by 16 publications

References 10 publications

Clinical studies of the treatment of facial atrophic acne scars and acne with a bipolar fractional radiofrequency system

Clinical studies of the treatment of facial atrophic acne scars and acne with a bipolar fractional radiofrequency system

A split‐face comparison of a fractional microneedle radiofrequency device and fractional radiofrequency therapy for moderate‐to‐severe acne vulgaris

High versus moderate energy use of bipolar fractional radiofrequency in the treatment of acne scars: a split-face double-blinded randomized control trial pilot study

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