Histological studies of the effects of monosodium glutamate on the fallopian tubes of adult female wistar rats

Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review

“…Degenerative and atrophic processes were observed at both doses with more pronounced changes in the group treated with higher dose (0.08 mg/kg) of MSG (Eweka and Om'iniabohs 2011). Similarly in fallopian tube, both MSG doses caused distortion of the basement membrane with the separation of the endosalpinx from the myosalpinx, however in rats taking 0.08 mg/kg, vacuolations and lysed red blood cells appeared in some parts of the stroma cells (Eweka et al 2010). Although these studies have shown the effects of MSG on female reproductive organs in relevant doses after peroral intake, further studies must be done to corroborate these results and to explore the ingested MSG effects also on male sex organs.…”

“…MSG caused cellular hypertrophy of the theca folliculi, destruction of the basement membrane and stroma cells` vacuolations in the ovaries. Degenerative and atrophic processes were observed at both doses with more pronounced changes in the group treated with higher dose (0.08 mg/kg) of MSG (Eweka and Om'iniabohs 2011). Similarly in fallopian tube, both MSG doses caused distortion of the basement membrane with the separation of the endosalpinx from the myosalpinx, however in rats taking 0.08 mg/kg, vacuolations and lysed red blood cells appeared in some parts of the stroma cells (Eweka et al 2010).…”

“…From this point of view, more important are the studies in which MSG was mixed with the grower's mash in adults. In adult female Wistar rats fed by MSG at the doses of 0.04 mg/kg or 0.08 mg/kg on a daily basis the pathological changes have been observed in ovaries (Eweka and Om'iniabohs 2011) and fallopian tube (Eweka et al 2010). MSG caused cellular hypertrophy of the theca folliculi, destruction of the basement membrane and stroma cells` vacuolations in the ovaries.…”

Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats

“…Pharmacological studies have demonstrated that tetramethylpyrazine (TMP) reduces ischemia/reperfusion damage of the spinal cord through multiple mechanisms, 1 and that deferoxamine (DFO) is an effective agent for the improvement of regeneration and functional recovery of nerve injury. 2 One of the critical mechanisms of spinal ischemia/ reperfusion injury involves the release of glutamate, 3 in which excessive glutamate results in the death of nerve cells. 4 Additional studies have shown that the overexpression of metabotropic glutamate receptor-1 (mGluR-1) mRNA observed after ischemia/reperfusion suggests that mGluR-1 is involved in the process of ischemia/reperfusion injury.…”

Molecular characterization of yohimbine hydrochloride using vibrational spectroscopy and quantum chemical calculations

“…Yohimbine hydrochloride (17α -hydroxy -yohimbane 16α -carboxylic acid methyl ester hydrochloride), a standard form belongs to an orthorhombic system, probable space group P2 1 2 1 2 1 having lattice parameters, a = 11.54Å, b = 24.88Å, c = 7.00Å and z = 4 [2]. It has been known as an aphrodisiac compound [2,3] and used traditionally since before the last century, even in the crude form by the African natives, and promoted for erectile dysfunction, weight loss (by releasing norepinephrine and blocking alpha-2 receptors) and depression (by blocking an enzyme called monoamine oxidase) [4][5][6]. It is used in tablets, capsule and tincture form for increased serumtesterone levels, muscle growth and strength, weight-loss, reduce fatigue in AIDS patients and libido enhancer [7].…”