Histological Studies of Vascularised Nerve Graft and Conventional Nerve Graft

Abstract

Histological studies of vascularised nerve graft versus conventional nerve graft were performed in eighteen rat femoral nerves using microsurgical technique. This experiment showed that there was no difference in the degree of vascularisation, reticulin framework collapse, rate and extent of axonal regeneration and remyelination between the two groups.

Vascularized Ulnar Nerve Graft: 151 Reconstructions for Posttraumatic Brachial Plexus Palsy

“…30,31 However, Mani et al did not find any significant difference between vascularized and nonvascularized nerve grafts in avascular graft beds, even after prolonged initial period of revascularization for nonvascularized nerve grafts. 32 Normal recipient bed experimental studies are conflicted as to which produces the best results: Restrepo et al, 33 Shibata et al, 34 Kanaya et al, 35 and Schultes et al 36 reported better results with vascularized nerve grafts, whereas McCullough et al, 37 Pho et al, 38 and Seckel et al 39 did not find any difference.…”

Experimental study of vascularized nerve graft: Evaluation of nerve regeneration using choline acetyltransferase activity

“…They were transplanted to a nerve defect in the sciatic nerve of syngeneic recipient rats. At 2, 4,6,8,12,16, and 24 weeks after operation, the sciatic nerves were biopsied and processed for evaluation of choline acetyltransferase (CAT) activity, histological studies, and measurement of wet weight of the muscle innervated by the sciatic nerve. Electrophysiological evaluation of the grafted nerve was also performed before sacrifice.…”

Prefabrication of a Free Peripheral Nerve Graft Following Implantation on an Arteriovenous Pedicle

“…The essential factor in successful nerve grafting is assuring adequate blood supply. [1][2][3][4][5][6][7][8][9]16,22,23 This is accomplished with non-vascularized nerve grafts (NVNG) by manipulation of the donor nerve and the vascularity of the recipient bed. An NVNG must acquire its blood supply from its recipient site.…”

“…[13][14][15][16][17] Controversy still exists about the advantages of VNGs over NVNGs in a normal bed. [2][3][4][5][6][7][8][9]17,22,23,35 Conventional devascularized nerve grafts reportedly revascularize from as early as 72 hr to as late as 3 weeks. [13][14][15][16][17]22,35 The most frequently mentioned mechanism of revascularization is centripetal neovascularization.…”

“…[1][2][3][4] However, controversy still exists about the advantage of vascularized nerve grafts over non-vascularized nerve grafts in a normal bed. [5][6][7][8] Many methods have been attempted to improve blood supply, but most are limited to special cases. [9][10][11] Nerve grafts, either vascularized or non-vascularized, have several inherent advantages and disadvantages.…”