Histological Study in Contralateral Testis of Prepubertal Children following Unilateral Testicular Torsion

Domínguez, Carlos; M, Martínez Verduch; Estornell, F; García, Fernando Cano; M, Hernandez; García-Ibarra, F

doi:10.1159/000475368

Cited by 15 publications

(8 citation statements)

References 19 publications

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“…19 Other reports have suggested the presence of a congenital testicular dysplasia as the basis for reduced fertility in torsion. 20,21 The conclusions about the role of congenital pathologic conditions, however, were based on the lack of relationship between the histological changes in the contralateral testis and the duration of torsion or the interval since torsion. 20,21 Because this observation might indicate that reduced fertility in torsion is not preventable, preservation of as much testicular tissue as possible would seem to be a priority.…”

Section: Resultsmentioning

confidence: 99%

Article

Mansbach

Forbes

Peters

2005

Arch Pediatr Adolesc Med

150

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Section: Resultsmentioning

confidence: 99%

Article

Mansbach

Forbes

Peters

2005

Arch Pediatr Adolesc Med

150

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“…The damage to the contralateral testis in these situations is called sympathetic orchiopathy [20]. Most studies over the last decade also suggest that contralateral testicular damage can occur after UTT, although some do not, with subsequent diminished fertility [21,22].…”

Section: Discussionmentioning

confidence: 99%

Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on apoptotic changes in contralateral testis following unilateral testicular torsion

et al. 2008

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ACE inhibition and AT1 receptor blockade reduced the tubular damage and apoptosis in the contralateral testes after UTT. The beneficial effect of these drugs may arise from inhibition of ischemic process resulting from increased sympathetic activity and elimination of insults subsequent to dysregulation of RAS. These results suggest that ACE inhibitors and AT1 receptor blockers may be of potential value in patients with UTT.

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“…The reported incidence of histologically documented lesions on the contralateral side tend to accredit the thesis of pre‐existing congenital dysplastic lesion 27 …”

Section: Discussionmentioning

confidence: 99%

Prenatal testicular torsion: Ultrasonographic features, management and histopathological findings

Arena

Nicòtina²,

Romeo

et al. 2006

Int J of Urology

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Aim : To highlight the ultrasonographic features of prenatal torsion of the testis in utero (IUTT) at presentation, the neonatal management and the histological findings postorchiectomy or biopsy. Methods : Seven newborns underwent emergency exploration for IUTT. All patients underwent a sonography and real-time color Doppler ultrasound study of the scrotum before any surgical procedure. A histological examination was performed in the removed specimens. Results : Sonography of the scrotum revealed enlarged, heterogeneous testes. In all cases the color and power Doppler did not reveal any flow signal on the affected side. Four newborn with unilateral testicular torsion underwent orchiectomy and contralateral orchidopexy. In one neonate after detorsion and with the absence of gangrenous changes and a reassuring biopsy, a twisted testis could be treated conservatively with orchidopexy. In another case, the parents, acknowledging the inviability of the affected testis, gave consent only for a biopsy of the testis. In the neonate with bilateral IUTT, bilateral testicular biopsies were performed. Histology of the removed testes variably showed interstitial red cell extravasion and coagulation or hemorrhagic necrosis. Light microscopy of the preserved testis highlighted surviving seminiferous tubules, with gonocytes, spermatogonia and fetal Sertoli cells. Conclusions : An early diagnosis and treatment in IUTT is essential. Surgical exploration should be always performed through the inguinal route. In bilateral IUTT testes should be left to try to assure, as long as possible, a residual Leydig cell function.

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Histological Study in Contralateral Testis of Prepubertal Children following Unilateral Testicular Torsion

Cited by 15 publications

References 19 publications

Article

Article

Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on apoptotic changes in contralateral testis following unilateral testicular torsion

Prenatal testicular torsion: Ultrasonographic features, management and histopathological findings

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